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The map label for this gene is mdcC [H]

Identifier: 145294400

GI number: 145294400

Start: 390578

End: 391705

Strand: Reverse

Name: mdcC [H]

Synonym: cgR_0355

Alternate gene names: 145294400

Gene position: 391705-390578 (Counterclockwise)

Preceding gene: 145294401

Following gene: 145294399

Centisome position: 11.82

GC content: 53.99

Gene sequence:

>1128_bases
ATGCAAATCATTAATGAAACTTTTCCTGCAACTATCCCTTTTCAACACGATATTCACGTTGGCGTCGTGGGCTCGGGTGA
TATGGAAATTCTGATTTCTGCACCCCGCAATGCTGGAAAAACCACGGTTAAAGTTGCCACCTCTGTTGATGGTTTTGATA
CCGTGTGGCGCAATGTGCTCAAGCGGTTCTTCGGCAGAAATCCTTTGGAAGCAGACATCACGATCAATGATTTCGGCGCC
ACCCCAGGCATGGCGATGCTGCGTCTGACCCAGGCATTTGAGCAGGCAACGTCACCGCAAACAATTGAAATCTCAGATTC
TTCACCGTTTACTGAGCTCAGCGCTCGGCAGCGTGTGCAATCACTCCTGGATCCGGGGACATTCCGCGAACTGCTTGATC
CTTTTCAAGAAATCCAATCTCCACACCTTGAACCGCAGGGCATCGTCCCTCAGCTCGATGATGGCGCGGTGCTGGGGCGC
GGAACCATCAACGGCGACTCCGCGATCGTCGTCGGGCTGGAAGGAAAATTCCAGGGAGGCGGCATCGGCGAGGTCTCAGG
CGCGAAAATCGCCGCAGCGCTTGAAAGAGCACTTGTCGACGCTAAAGCCGGACACAACATTCGCGTTGTCCTCCTGTTAG
AAACCGGTGGCATTCGTCTTCAGGAAGCCAATTTGGGATTGCTTGCCATCGCAGAAATCCATTCCGCCATTGTGGAACTG
CAAAGGTACACCCCGGTGGTTTGCGTTGTTGCCGGCATGGTTGGTTGCTTCGGCGGAATGGGAATCGCCGCCGGATTGTG
CGATCACATCATCATGACCCGCGAGGGACGTCTTGCGCTTAATGGCCCAGAAGTTATTGAAACTGAAGCCGGAGTCCAGG
AACTCAACGCCTCTGACCGCCCTGCCATCTGGAAAATGATCGGTGGCGAGCAACGTGTTGCCACTGGTCGTGCTGAAGTT
CTTTCCGATGACACGGTTGAATCTATCCGCGCCGCAGTTGTTGCCGCACCGGTTATGGCATACACCTACCACCGCGCCAA
CAACCTCGATAGTTTTAATGCCCAACTTGAAAACCTCAACCCCAGTGCCCGCCCCACTGCCGAAGAACTTCGCACTGTTT
CTGTATAG

Upstream 100 bases:

>100_bases
GCTTTTGATCAACACCTGACCAACCGCAACCTTTCCCCGGGCGGCAGTGCGGATCTGCTTGCTGGCGCCTTATTTTTAAC
CTCGATTTTTGGAGAATCTC

Downstream 100 bases:

>100_bases
GAGTACACCATGACCACCACGCTTAATTCCGCTGAACTTGGTACAACTTGGTTCAACACGCTTTCTACACAGATCACCTC
AACTGAAGGATCACTTCGAA

Product: hypothetical protein

Products: ADP; H+; Malonyl-CoA; Phosphate [C]

Alternate protein names: Malonate decarboxylase subunit delta [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MQIINETFPATIPFQHDIHVGVVGSGDMEILISAPRNAGKTTVKVATSVDGFDTVWRNVLKRFFGRNPLEADITINDFGA
TPGMAMLRLTQAFEQATSPQTIEISDSSPFTELSARQRVQSLLDPGTFRELLDPFQEIQSPHLEPQGIVPQLDDGAVLGR
GTINGDSAIVVGLEGKFQGGGIGEVSGAKIAAALERALVDAKAGHNIRVVLLLETGGIRLQEANLGLLAIAEIHSAIVEL
QRYTPVVCVVAGMVGCFGGMGIAAGLCDHIIMTREGRLALNGPEVIETEAGVQELNASDRPAIWKMIGGEQRVATGRAEV
LSDDTVESIRAAVVAAPVMAYTYHRANNLDSFNAQLENLNPSARPTAEELRTVSV

Sequences:

>Translated_375_residues
MQIINETFPATIPFQHDIHVGVVGSGDMEILISAPRNAGKTTVKVATSVDGFDTVWRNVLKRFFGRNPLEADITINDFGA
TPGMAMLRLTQAFEQATSPQTIEISDSSPFTELSARQRVQSLLDPGTFRELLDPFQEIQSPHLEPQGIVPQLDDGAVLGR
GTINGDSAIVVGLEGKFQGGGIGEVSGAKIAAALERALVDAKAGHNIRVVLLLETGGIRLQEANLGLLAIAEIHSAIVEL
QRYTPVVCVVAGMVGCFGGMGIAAGLCDHIIMTREGRLALNGPEVIETEAGVQELNASDRPAIWKMIGGEQRVATGRAEV
LSDDTVESIRAAVVAAPVMAYTYHRANNLDSFNAQLENLNPSARPTAEELRTVSV
>Mature_375_residues
MQIINETFPATIPFQHDIHVGVVGSGDMEILISAPRNAGKTTVKVATSVDGFDTVWRNVLKRFFGRNPLEADITINDFGA
TPGMAMLRLTQAFEQATSPQTIEISDSSPFTELSARQRVQSLLDPGTFRELLDPFQEIQSPHLEPQGIVPQLDDGAVLGR
GTINGDSAIVVGLEGKFQGGGIGEVSGAKIAAALERALVDAKAGHNIRVVLLLETGGIRLQEANLGLLAIAEIHSAIVEL
QRYTPVVCVVAGMVGCFGGMGIAAGLCDHIIMTREGRLALNGPEVIETEAGVQELNASDRPAIWKMIGGEQRVATGRAEV
LSDDTVESIRAAVVAAPVMAYTYHRANNLDSFNAQLENLNPSARPTAEELRTVSV

Specific function: Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism [H]

COG id: COG0777

COG function: function code I; Acetyl-CoA carboxylase beta subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mdcC family [H]

Homologues:

Organism=Escherichia coli, GI1788655, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009662
- ProDom:   PD015450 [H]

Pfam domain/function: PF06857 MdcD [H]

EC number: 6.4.1.2 [C]

Molecular weight: Translated: 39952; Mature: 39952

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIINETFPATIPFQHDIHVGVVGSGDMEILISAPRNAGKTTVKVATSVDGFDTVWRNVL
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHH
KRFFGRNPLEADITINDFGATPGMAMLRLTQAFEQATSPQTIEISDSSPFTELSARQRVQ
HHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
SLLDPGTFRELLDPFQEIQSPHLEPQGIVPQLDDGAVLGRGTINGDSAIVVGLEGKFQGG
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCEEEEEECCCCCCC
GIGEVSGAKIAAALERALVDAKAGHNIRVVLLLETGGIRLQEANLGLLAIAEIHSAIVEL
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCCEEHHHHHHHHHHHH
QRYTPVVCVVAGMVGCFGGMGIAAGLCDHIIMTREGRLALNGPEVIETEAGVQELNASDR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCEECCCCHHHCCCCCC
PAIWKMIGGEQRVATGRAEVLSDDTVESIRAAVVAAPVMAYTYHRANNLDSFNAQLENLN
CHHHHHCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
PSARPTAEELRTVSV
CCCCCCHHHHHCCCC
>Mature Secondary Structure
MQIINETFPATIPFQHDIHVGVVGSGDMEILISAPRNAGKTTVKVATSVDGFDTVWRNVL
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHH
KRFFGRNPLEADITINDFGATPGMAMLRLTQAFEQATSPQTIEISDSSPFTELSARQRVQ
HHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
SLLDPGTFRELLDPFQEIQSPHLEPQGIVPQLDDGAVLGRGTINGDSAIVVGLEGKFQGG
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCEEEEEECCCCCCC
GIGEVSGAKIAAALERALVDAKAGHNIRVVLLLETGGIRLQEANLGLLAIAEIHSAIVEL
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCCEEHHHHHHHHHHHH
QRYTPVVCVVAGMVGCFGGMGIAAGLCDHIIMTREGRLALNGPEVIETEAGVQELNASDR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCEECCCCHHHCCCCCC
PAIWKMIGGEQRVATGRAEVLSDDTVESIRAAVVAAPVMAYTYHRANNLDSFNAQLENLN
CHHHHHCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
PSARPTAEELRTVSV
CCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; ATP; Bicarbonate [C]

Specific reaction: Acetyl-CoA + ATP + Bicarbonate <==> ADP + H+ + Malonyl-CoA + Phosphate [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA