Click here to switch to the map view.

The map label for this gene is pat

Identifier: 145294342

GI number: 145294342

Start: 321780

End: 322805

Strand: Reverse

Name: pat

Synonym: cgR_0297

Alternate gene names: 145294342

Gene position: 322805-321780 (Counterclockwise)

Preceding gene: 145294345

Following gene: 145294341

Centisome position: 9.74

GC content: 55.75

Gene sequence:

>1026_bases
ATGATTAGAGCAGATTTGGCAACTATCCCTACTTATGTCCCTGGCCGTCGTCTTAATAATGCAACGAAGTTATCTAGTAA
TGAAGTCAGTTTTTCGCCTCTACCTGCAGCGGTTGATGCGGTGACGGAGGCTACTCAGGGGGCTAATCGGTACCCGGATA
TGGGTGCGGTTGAGCTCCGTGAGGCTCTTGCAGAGCATTTAGAGGTTGAGTTTGACCAGGTCACGGTAGGTTGCGGCTCG
TCTGCGCTGTGTCAACAGCTGGTTCAGGCAACGTGCGCTCAGGGCGATGAGGTCATTTTTCCATGGCGCAGCTTTGAGGC
TTATCCAATTTTCGCGCAGGTCGCGGGCGCCACTCCTGTTGCCATTCCGCTGACTGCTGATCAGAATCATGATCTTGATG
CGATGGCAGCCGCGATCACTGATAAGACCCGCCTGATTTTCATCTGCAACCCCAACAATCCTTCGGGCACCACCATCACC
CAGGCGCAGTTTGATAATTTCATGGAAAAGGTTCCAAACGATGTCGTTGTTGGGCTGGATGAGGCTTATTTTGAGTTCAA
CCGCGCGGACGACACCCCAGTTGCCACTGAGGAAATCCACCGCCACGACAACGTGATTGGTTTGCGCACGTTCTCCAAGG
CGTATGGCCTGGCGGGCTTGCGTGTTGGTTACGCCTTCGGAAACGCAGAGATCATCGCAGCGATGAATAAGGTGGCTATT
CCTTTCGCGGTGAATTCAGCAGCTCAGGCTGCAGCGCTTGCGAGTTTGAATTCTGCCGATGAGTTGATGGAACGGGTGGA
GGAAACCGTCGAAAAGCGTGATGCTGTGGTGGCAGCGCTTGGTACTGCGCCGACGCAGGCCAATTTCGTCTGGCTGCCGG
GCGAGGGCGCCGCTGAGTTGGCGGCTAAATTGGCCGAGCACGGCATCGTGATTCGCGCGTTCCCCGAGGGTGCGCGCATT
TCGGTGACCAACGCCGAGGAAACTGACAAGCTGCTGCGCGCGTGGGAGGCCATCAATGCTGGGTAG

Upstream 100 bases:

>100_bases
ACCGATATGTTACAGTACCCCCTCTTGCTAAATTTCAGCAAACCTGCATGTCAAAGGCTTAATCGGATGCGTGTCCATAG
GGGCTAGTACTGTGTAAATC

Downstream 100 bases:

>100_bases
TCTTTGGCGTTTTGCGGTGCGCACCGCAGCAGGCGCGGTGGCGTTGTGGGTGGTTATTAAGCTTATCGACGGCATCTCCC
TGAGTTTTCCCACCACACCT

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MIRADLATIPTYVPGRRLNNATKLSSNEVSFSPLPAAVDAVTEATQGANRYPDMGAVELREALAEHLEVEFDQVTVGCGS
SALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPVAIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTIT
QAQFDNFMEKVPNDVVVGLDEAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVAALGTAPTQANFVWLPGEGAAELAAKLAEHGIVIRAFPEGARI
SVTNAEETDKLLRAWEAINAG

Sequences:

>Translated_341_residues
MIRADLATIPTYVPGRRLNNATKLSSNEVSFSPLPAAVDAVTEATQGANRYPDMGAVELREALAEHLEVEFDQVTVGCGS
SALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPVAIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTIT
QAQFDNFMEKVPNDVVVGLDEAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVAALGTAPTQANFVWLPGEGAAELAAKLAEHGIVIRAFPEGARI
SVTNAEETDKLLRAWEAINAG
>Mature_341_residues
MIRADLATIPTYVPGRRLNNATKLSSNEVSFSPLPAAVDAVTEATQGANRYPDMGAVELREALAEHLEVEFDQVTVGCGS
SALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPVAIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTIT
QAQFDNFMEKVPNDVVVGLDEAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVAALGTAPTQANFVWLPGEGAAELAAKLAEHGIVIRAFPEGARI
SVTNAEETDKLLRAWEAINAG

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=26.890756302521, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786816, Length=266, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788722, Length=280, Percent_Identity=26.0714285714286, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788627, Length=257, Percent_Identity=26.0700389105058, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=25.3521126760563, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PATR_CORGB (A4QAL4)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137163.1
- ProteinModelPortal:   A4QAL4
- SMR:   A4QAL4
- STRING:   A4QAL4
- GeneID:   4994567
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0297
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- ProtClustDB:   PRK03321
- HAMAP:   MF_01513
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 36420; Mature: 36420

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRADLATIPTYVPGRRLNNATKLSSNEVSFSPLPAAVDAVTEATQGANRYPDMGAVELR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
EALAEHLEVEFDQVTVGCGSSALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPV
HHHHHHHCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEHEECCCCCCE
AIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTITQAQFDNFMEKVPNDVVVGLD
EEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEECH
EAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
HHHHCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHCCCCEEEEEEECCCCEEEEHHHEEE
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVAALGTAPTQANFVWLPGEGAAEL
EEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCCCHHHH
AAKLAEHGIVIRAFPEGARISVTNAEETDKLLRAWEAINAG
HHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRADLATIPTYVPGRRLNNATKLSSNEVSFSPLPAAVDAVTEATQGANRYPDMGAVELR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
EALAEHLEVEFDQVTVGCGSSALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPV
HHHHHHHCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEHEECCCCCCE
AIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTITQAQFDNFMEKVPNDVVVGLD
EEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEECH
EAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
HHHHCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHCCCCEEEEEEECCCCEEEEHHHEEE
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVAALGTAPTQANFVWLPGEGAAEL
EEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCCCHHHH
AAKLAEHGIVIRAFPEGARISVTNAEETDKLLRAWEAINAG
HHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA