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The map label for this gene is merA [H]

Identifier: 145294206

GI number: 145294206

Start: 178413

End: 179834

Strand: Reverse

Name: merA [H]

Synonym: cgR_0163

Alternate gene names: 145294206

Gene position: 179834-178413 (Counterclockwise)

Preceding gene: 145294214

Following gene: 145294203

Centisome position: 5.43

GC content: 71.8

Gene sequence:

>1422_bases
ATGCCTACGAAGTACGATCTCGCCATCATCGGATCGGGAGGCGGCGCGTTCGCCGCTGCGATCCGCGCCAGCACGCTCGG
AAAGTCGGTGGTGATGATCGAGCGCGGGACGCTCGGCGGCACCTGCGTGAACACGGGCTGCGTCCCGTCGAAGGCGCTCA
TCGCCGCGGCCGGCGCGCGGCACGTCGCCGTCGACGCCGCAACCCGGTTCCCCGGGATCGCGACGACGGCGGATCCCGTC
GACATGCCCGCGCTGATCGCTGGGAAGCAAGCGTTGGTGGAGTCGCTGCGCGGCGAGAAGTACGCCGACGTCGCCGACTC
CTACGGCTGGCAGGTCCTCCGCGGCGACGCCTCGTTCGTGGGCACCCCTGATGCGCCGGTTCTCGATGTTGCCGGAGCCG
ACAGAAGCGTCGAGACCATCGAGGCCCACCACTACCTGGTCGCGACTGGTTCTCGCCCGTGGGCACCGCCGATCGACGGC
CTGGAGGAGACCGGATACCTGACCTCGACCACGGCGATGGAGCTGACGGAGGTCCCCGAGTCGCTGCTGGTGCTCGGCGG
CGGCTACGTCGCCCTGGAGCAGGCGCAGCTGTTCGCCCGCCTCGGCTCGCAGGTCACGCTGCTCGTGCGGTCCCGGCTCG
CCTCGAAGGAGGAGCCGGAGGTGTCGAAGGCGCTCCAGGAGGTGTTCGCCGACGAGGGCATCCGCGTCGTCAGCCGCGCA
GTGCCCACCCGGGTCTCCCGCGGCACGGGAGGCGAGGCCGTCGTGACCGCCGCCGTGTCCGGCGGCTCGCAGGAGTTCCG
CGCCGACCAGGTCCTGGTCGCCCTCGGACGCCGTCCCGTCACCGATGGCCTGAACCTCGATGCGGTCGGGGTGAAGACCG
GAGACTCCGGCGAGGTGGTCGTCTCCGACCGGCTGCAGTCCTCGAACCCGCGGATCTGGGCCGCGGGCGACGTGACCGGG
CACCCCGAGTTCGTCTACGTCGCCGCCCACCACGGCACCCTCGTCGCCGAGAACGCGTTCGCCGACGCCGACCGGTCCGT
CGACTACGCCCGCCTGCCGCGGGTGACGTTCACCGGGCCCGCGATCGGCGCGGTCGGGATGACCGAGAAGGACGTCCTCG
CCGCGGGGATCCGCTGCGACTGCCGCGTCCTGCCCCTGCACCACGTGCCCCGCGCCTTGGTGAACCGCGACACCCGCGGG
TTCATCAAGATCGTCGTGAACGCCGAGACGAACGAGATCCTCGGCCTGACCGCCGTCGCCAAGGACGCCGGGGAGCTCGC
CGCCGCAGGCGTCCACGTGCTCGGCAGGACCGTCGCCGAGGTCGCCGACGCCTGGGCCCCCTACCTGACCATGGCCGAGG
GCATCCGGATCGCCGCGAAGGCCTTCACCACCGACCCGTCGCTGCTGTCGTGCTGCGCATGA

Upstream 100 bases:

>100_bases
ATTGCTGTCTCCCTCCGTGGCCGCGCTTGACCTTCCCCTGTACTGGAAGGTCCAGTATGGCTGAGACAGAGCAGAAAGCC
AAGAGTTAACAGGAGCAGCG

Downstream 100 bases:

>100_bases
ACGGCAACGCAGGCAATCGGGGAGATCTCATCCTGAAGAGGTGCATACGAAGAGCGCCCCTCCCCCTTGGTGGCTCCTGT
CGGTTTTGAGATAAAGATGA

Product: hypothetical protein

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MPTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGARHVAVDAATRFPGIATTADPV
DMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFVGTPDAPVLDVAGADRSVETIEAHHYLVATGSRPWAPPIDG
LEETGYLTSTTAMELTEVPESLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
VPTRVSRGTGGEAVVTAAVSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVKTGDSGEVVVSDRLQSSNPRIWAAGDVTG
HPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGPAIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRG
FIKIVVNAETNEILGLTAVAKDAGELAAAGVHVLGRTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA

Sequences:

>Translated_473_residues
MPTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGARHVAVDAATRFPGIATTADPV
DMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFVGTPDAPVLDVAGADRSVETIEAHHYLVATGSRPWAPPIDG
LEETGYLTSTTAMELTEVPESLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
VPTRVSRGTGGEAVVTAAVSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVKTGDSGEVVVSDRLQSSNPRIWAAGDVTG
HPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGPAIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRG
FIKIVVNAETNEILGLTAVAKDAGELAAAGVHVLGRTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA
>Mature_472_residues
PTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGARHVAVDAATRFPGIATTADPVD
MPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFVGTPDAPVLDVAGADRSVETIEAHHYLVATGSRPWAPPIDGL
EETGYLTSTTAMELTEVPESLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRAV
PTRVSRGTGGEAVVTAAVSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVKTGDSGEVVVSDRLQSSNPRIWAAGDVTGH
PEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGPAIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRGF
IKIVVNAETNEILGLTAVAKDAGELAAAGVHVLGRTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=481, Percent_Identity=30.3534303534304, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI50301238, Length=426, Percent_Identity=29.5774647887324, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI22035672, Length=491, Percent_Identity=31.1608961303462, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=28.3062645011601, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=28.3062645011601, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=28.3062645011601, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=28.3062645011601, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI148277071, Length=431, Percent_Identity=28.3062645011601, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI291045266, Length=449, Percent_Identity=27.6169265033408, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI291045268, Length=410, Percent_Identity=28.780487804878, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789915, Length=372, Percent_Identity=37.0967741935484, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=30.406852248394, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=29.6943231441048, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI87082354, Length=479, Percent_Identity=28.1837160751566, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=32.9741379310345, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71983419, Length=357, Percent_Identity=29.9719887955182, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=357, Percent_Identity=29.9719887955182, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17557007, Length=500, Percent_Identity=27, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=475, Percent_Identity=27.3684210526316, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321091, Length=478, Percent_Identity=30.1255230125523, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=476, Percent_Identity=26.890756302521, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=481, Percent_Identity=27.8586278586279, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=32.6881720430108, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI17737741, Length=491, Percent_Identity=29.1242362525458, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24640553, Length=501, Percent_Identity=27.5449101796407, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24640549, Length=501, Percent_Identity=27.5449101796407, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24640551, Length=501, Percent_Identity=26.9461077844311, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 49083; Mature: 48952

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGAR
CCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCCCHHHHHHCCCC
HVAVDAATRFPGIATTADPVDMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFV
EEEEEHHHCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCC
GTPDAPVLDVAGADRSVETIEAHHYLVATGSRPWAPPIDGLEETGYLTSTTAMELTEVPE
CCCCCCEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHCCC
SLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
EEEEECCCEEEHHHHHHHHHCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHH
VPTRVSRGTGGEAVVTAAVSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVKTGDSGEVV
HCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEE
VSDRLQSSNPRIWAAGDVTGHPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGP
EECCCCCCCCCEEEECCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCHHHCCEEEECCC
AIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRGFIKIVVNAETNEILGLTAVA
CCCCCCCCCHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHH
KDAGELAAAGVHVLGRTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCC
>Mature Secondary Structure 
PTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGAR
CCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCCCHHHHHHCCCC
HVAVDAATRFPGIATTADPVDMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFV
EEEEEHHHCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCC
GTPDAPVLDVAGADRSVETIEAHHYLVATGSRPWAPPIDGLEETGYLTSTTAMELTEVPE
CCCCCCEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHCCC
SLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
EEEEECCCEEEHHHHHHHHHCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHH
VPTRVSRGTGGEAVVTAAVSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVKTGDSGEVV
HCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEE
VSDRLQSSNPRIWAAGDVTGHPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGP
EECCCCCCCCCEEEECCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCHHHCCEEEECCC
AIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRGFIKIVVNAETNEILGLTAVA
CCCCCCCCCHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHH
KDAGELAAAGVHVLGRTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1494353 [H]