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The map label for this gene is copA [H]

Identifier: 145294162

GI number: 145294162

Start: 139741

End: 141222

Strand: Reverse

Name: copA [H]

Synonym: cgR_0120

Alternate gene names: 145294162

Gene position: 141222-139741 (Counterclockwise)

Preceding gene: 145294163

Following gene: 145294160

Centisome position: 4.26

GC content: 64.57

Gene sequence:

>1482_bases
ATGACAAGTAGTTTTTCCCGGCGACAGTTTCTGCTCGGCGGGCTCGTACTCGCCGGCACCGGGGCCGTGGCCGCCTGCAC
CAGCGACCCTGGACCCGCTGCCTCGGCACCAGGTCCCTCCCTTCGCCCCACTCCCACCCCCACTGCGCTCGGTGAGCCGA
CGGTGCGCCGGACACTGACCGCCCGGCCCCTCTCCCTGGATATCGGCGGCATCGAAGCCAAGACGTGGGGATACGTCTCT
GACACCGGGGATGCGGCCATTGAGGCCACCGCCGGCGACGTCCTCCAGGTCGATATCACCAATGAACTGCCTGAGAGCAC
CTCCATCCACTGGCATGGCATCGCACTCCACAACGCAGCCGACGGTGTGCCCGGCATGACCCAGGACCCCATTGAACCTG
GCGAGTCTTTCTCCTATGTTTTTGAAGTCCCCCACGCTGGCACCTACTTCTACCATTCCCACACCGGCCTGCAGCTTGAT
CGCGGCCTCCACGCCCCACTGATCATCCGTGACCCGCAAGACGCTGAGGACCAGGACGTCGAGTGGACCATCGTGCTCGA
CGACTGGGTCGATGGCATTCAGGGCACTCCCGACGATGAGCTCGACAAGCTCACCGGAATGGGTTCGGGCGACCATAACG
GGAGGATGGGAATGGGAGGTCACGGCCAGATGATGCACGGCACCCCGGACCGGGTACTGGGCGGGGATGTCGGCGATGTG
ATGTATCCGCACTACCTCATCAACGGACGTATCCCCCGTGCTCACCGGACCTTCGAGGCTCGCCCGGGCGACAAGGCCCG
CCTGCGGTTTATCAACTCCGGCGGTGACACCATCTTCAAGGTGGCCCTCGGTGGTCACCGCATGACCGTCACCCACACCG
ACGGCTTCCCTGTCCAGCCCTGGGAGACCGAATCGATCTACCTGTCGATGGGCGAGCGTGTCGACGTCGAGGTCATCCTC
GGCGACGGCATCTTCCCGCTCACGGCTTTGGCGGTGGGTAAGGACGACCGCGCCTTCGCCGTCATCCGCACCGCCGGCGG
CCAGGCCCCCCGCCCCGATGTCGACTTCCCCGAGTTGTCGTCCACCGGACTGCTTCTGTCCTCCCTGAAGCCAGCAGACC
GTGCACTCCTGCCCGAGGGCACACCAGACCGAGAAGTCAGCATCGACCTGGGCGGGCAGATGATGCCGTATGAATGGAGC
ATTCTCACCGACGGCCAATCCTCCTCCGCGACCGTGCAGGAGGGCCAGCGCCTGCGGATGGTCATGCGCAACAGGACCAT
GATGCCCCATCCCATGCACATCCACGGCCACACCTGGGCGCTACCCGGCAGCGGCGGGCTACGCAAGGACACCGTCCTTC
TCCGCCACGGTGAAACCATGATCGCCGACCTGATCGCTGACAACCCCGGTGAGTGGGCATTTCACTGCCATAACGCCTAT
CACATGGAAACCGGGATGGTCAGCTCGCTTCGCTACGAGTAA

Upstream 100 bases:

>100_bases
ACCTGTGTCACGGACCTGCGCCTGACCTGATGCCTCAGCAGTGGGTTTCCCCTGATCCTTCCCCTGTGTCACTCAGACTT
GCACCAAGGACGGTTTAACC

Downstream 100 bases:

>100_bases
CCCCCACAGCAGGGTTGAGTGCCGAGGTGGGCAGAGTCGCTGCAGACCACCCACCGGGCAGCACGATGACCTTCCTCGGT
GTTGTGGTCTTCCGGGACAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTSSFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGPSLRPTPTPTALGEPTVRRTLTARPLSLDIGGIEAKTWGYVS
DTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAADGVPGMTQDPIEPGESFSYVFEVPHAGTYFYHSHTGLQLD
RGLHAPLIIRDPQDAEDQDVEWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGRMGMGGHGQMMHGTPDRVLGGDVGDV
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQPWETESIYLSMGERVDVEVIL
GDGIFPLTALAVGKDDRAFAVIRTAGGQAPRPDVDFPELSSTGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWS
ILTDGQSSSATVQEGQRLRMVMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HMETGMVSSLRYE

Sequences:

>Translated_493_residues
MTSSFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGPSLRPTPTPTALGEPTVRRTLTARPLSLDIGGIEAKTWGYVS
DTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAADGVPGMTQDPIEPGESFSYVFEVPHAGTYFYHSHTGLQLD
RGLHAPLIIRDPQDAEDQDVEWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGRMGMGGHGQMMHGTPDRVLGGDVGDV
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQPWETESIYLSMGERVDVEVIL
GDGIFPLTALAVGKDDRAFAVIRTAGGQAPRPDVDFPELSSTGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWS
ILTDGQSSSATVQEGQRLRMVMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HMETGMVSSLRYE
>Mature_492_residues
TSSFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGPSLRPTPTPTALGEPTVRRTLTARPLSLDIGGIEAKTWGYVSD
TGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAADGVPGMTQDPIEPGESFSYVFEVPHAGTYFYHSHTGLQLDR
GLHAPLIIRDPQDAEDQDVEWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGRMGMGGHGQMMHGTPDRVLGGDVGDVM
YPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQPWETESIYLSMGERVDVEVILG
DGIFPLTALAVGKDDRAFAVIRTAGGQAPRPDVDFPELSSTGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWSI
LTDGQSSSATVQEGQRLRMVMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAYH
METGMVSSLRYE

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=513, Percent_Identity=26.7056530214425, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323703, Length=465, Percent_Identity=24.0860215053763, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321067, Length=489, Percent_Identity=23.3128834355828, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320714, Length=488, Percent_Identity=23.7704918032787, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28574104, Length=283, Percent_Identity=30.0353356890459, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18859919, Length=240, Percent_Identity=29.5833333333333, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221329998, Length=311, Percent_Identity=29.2604501607717, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221330000, Length=346, Percent_Identity=28.3236994219653, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585842, Length=247, Percent_Identity=30.3643724696356, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281360167, Length=247, Percent_Identity=30.3643724696356, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650186, Length=233, Percent_Identity=26.1802575107296, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 53196; Mature: 53065

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGPSLRPTPTPTALGEPTVRRTLT
CCCCCCHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEE
ARPLSLDIGGIEAKTWGYVSDTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAA
CCCEEEECCCEEECCCCEEECCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEECCC
DGVPGMTQDPIEPGESFSYVFEVPHAGTYFYHSHTGLQLDRGLHAPLIIRDPQDAEDQDV
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCEEEECCCCCCCCCC
EWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGRMGMGGHGQMMHGTPDRVLGGDVGDV
EEEEEEHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHH
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQP
CCCEEEECCCCCCCCCCEECCCCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCC
WETESIYLSMGERVDVEVILGDGIFPLTALAVGKDDRAFAVIRTAGGQAPRPDVDFPELS
CCCCEEEEECCCEEEEEEEECCCCHHEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCC
STGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWSILTDGQSSSATVQEGQRLRM
CCCEEEECCCCCHHCCCCCCCCCCEEEEECCCEECCEEEEEEECCCCCCCHHHHHHHHHH
VMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HHHCCCCCCCCEEECCCEEECCCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECCEE
HMETGMVSSLRYE
EECCCCHHHHCCC
>Mature Secondary Structure 
TSSFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGPSLRPTPTPTALGEPTVRRTLT
CCCCCHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEE
ARPLSLDIGGIEAKTWGYVSDTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAA
CCCEEEECCCEEECCCCEEECCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEECCC
DGVPGMTQDPIEPGESFSYVFEVPHAGTYFYHSHTGLQLDRGLHAPLIIRDPQDAEDQDV
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCEEEECCCCCCCCCC
EWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGRMGMGGHGQMMHGTPDRVLGGDVGDV
EEEEEEHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHH
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQP
CCCEEEECCCCCCCCCCEECCCCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCC
WETESIYLSMGERVDVEVILGDGIFPLTALAVGKDDRAFAVIRTAGGQAPRPDVDFPELS
CCCCEEEEECCCEEEEEEEECCCCHHEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCC
STGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWSILTDGQSSSATVQEGQRLRM
CCCEEEECCCCCHHCCCCCCCCCCEEEEECCCEECCEEEEEEECCCCCCCHHHHHHHHHH
VMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HHHCCCCCCCCEEECCCEEECCCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECCEE
HMETGMVSSLRYE
EECCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]