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The map label for this gene is pdxK [H]

Identifier: 138897012

GI number: 138897012

Start: 3489822

End: 3490637

Strand: Direct

Name: pdxK [H]

Synonym: GTNG_3383

Alternate gene names: 138897012

Gene position: 3489822-3490637 (Clockwise)

Preceding gene: 138897011

Following gene: 138897014

Centisome position: 98.3

GC content: 53.8

Gene sequence:

>816_bases
ATGACGATGCCCAAAGCATTAACGATCGCCGGCTCAGACAGCAGTGGCGGCGCTGGACTGCAAGCGGATATAAAAACCTT
TCAAGAGCTTGGCGTGTATGGAATGACGGCGATTACGACAATCGTCGCCATGGATCCGCACAATCGTTGGGCGCATCAAG
TGTTTCCTGTTGACTTGGCAACGATCGAAGCTCAGCTTGAGACGATCATCGTCGGTGTCGGCGTTGACGCCTTAAAAACA
GGGATGTTACCGACGACTGACATCATTGAGTTGGCCGCACGAACGATTGAAAAACACGGCTTAACAAACGCCGTCATCGA
CCCAGTCATGGTGTGCAAAGGGGCGGACGAGCCGCTTCACCCAGAAAATACAGTGTGCTACCGTGAAACGCTCGTGCCAA
AAGCGACGGTTGTGACGCCGAATTTGTTTGAGGCAGCTCAATTATCCGGTCTGCCGCGCATTGAAACGGTGGAAGATATG
AAAGAGGCAGCCGGGCGCATTCATGAGCTCGGCGCGCAATATGTCATCGTCAAAGGTGGACGGAAAATCCCGCATGACTA
CGCAGTCGATGTCCTCTATGACGGCAAAACGTTCGAGCTGCTTGAATCAGAACGAATTGAAACGACGTATACACATGGAG
CCGGCTGTACGTTCTCGGCGGCCATCGCTGCCGAACTGGCAAAAGGCCGCCCGGTCAAAGACGCCATTGCGACCGCCAAG
GCGTTCATCACCGCTGCCATTCGCCATTCATTCCCATTAAACGAATACGTCGGACCGACACACCACGGCGCTTACCGCCG
CTATATGGAACAATAG

Upstream 100 bases:

>100_bases
TCGCTTGTTCTCGAGATCTTTTCTGCCGATGTGGAACGACTGTTTTATCCTTGAGACAGATTCATGATATGATTTTCATT
AAAAAGGAGAGTGAATCACG

Downstream 100 bases:

>100_bases
ACAAGGCTTCAGCCTTGTCTTTTTTTATCAAGCAGCAGGTGGCCGCATCGGGACATCTAACTGCCGTCTCGCCGTCAAAA
ACAGATTTCATGATGAGGTT

Product: pyridoxal kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTMPKALTIAGSDSSGGAGLQADIKTFQELGVYGMTAITTIVAMDPHNRWAHQVFPVDLATIEAQLETIIVGVGVDALKT
GMLPTTDIIELAARTIEKHGLTNAVIDPVMVCKGADEPLHPENTVCYRETLVPKATVVTPNLFEAAQLSGLPRIETVEDM
KEAAGRIHELGAQYVIVKGGRKIPHDYAVDVLYDGKTFELLESERIETTYTHGAGCTFSAAIAAELAKGRPVKDAIATAK
AFITAAIRHSFPLNEYVGPTHHGAYRRYMEQ

Sequences:

>Translated_271_residues
MTMPKALTIAGSDSSGGAGLQADIKTFQELGVYGMTAITTIVAMDPHNRWAHQVFPVDLATIEAQLETIIVGVGVDALKT
GMLPTTDIIELAARTIEKHGLTNAVIDPVMVCKGADEPLHPENTVCYRETLVPKATVVTPNLFEAAQLSGLPRIETVEDM
KEAAGRIHELGAQYVIVKGGRKIPHDYAVDVLYDGKTFELLESERIETTYTHGAGCTFSAAIAAELAKGRPVKDAIATAK
AFITAAIRHSFPLNEYVGPTHHGAYRRYMEQ
>Mature_270_residues
TMPKALTIAGSDSSGGAGLQADIKTFQELGVYGMTAITTIVAMDPHNRWAHQVFPVDLATIEAQLETIIVGVGVDALKTG
MLPTTDIIELAARTIEKHGLTNAVIDPVMVCKGADEPLHPENTVCYRETLVPKATVVTPNLFEAAQLSGLPRIETVEDMK
EAAGRIHELGAQYVIVKGGRKIPHDYAVDVLYDGKTFELLESERIETTYTHGAGCTFSAAIAAELAKGRPVKDAIATAKA
FITAAIRHSFPLNEYVGPTHHGAYRRYMEQ

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates. Can also use hydroxymethylpyrimidine (HMP) as substrate [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=264, Percent_Identity=36.3636363636364, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325378, Length=276, Percent_Identity=32.6086956521739, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324997, Length=255, Percent_Identity=31.3725490196078, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324517, Length=257, Percent_Identity=30.7392996108949, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 29242; Mature: 29111

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPKALTIAGSDSSGGAGLQADIKTFQELGVYGMTAITTIVAMDPHNRWAHQVFPVDLA
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHEEEEECCCCCCHHEEECCHHH
TIEAQLETIIVGVGVDALKTGMLPTTDIIELAARTIEKHGLTNAVIDPVMVCKGADEPLH
HHHHEEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
PENTVCYRETLVPKATVVTPNLFEAAQLSGLPRIETVEDMKEAAGRIHELGAQYVIVKGG
CCCCEEEHHHCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
RKIPHDYAVDVLYDGKTFELLESERIETTYTHGAGCTFSAAIAAELAKGRPVKDAIATAK
CCCCCCCEEEEEECCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHH
AFITAAIRHSFPLNEYVGPTHHGAYRRYMEQ
HHHHHHHHHCCCHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TMPKALTIAGSDSSGGAGLQADIKTFQELGVYGMTAITTIVAMDPHNRWAHQVFPVDLA
CCCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHEEEEECCCCCCHHEEECCHHH
TIEAQLETIIVGVGVDALKTGMLPTTDIIELAARTIEKHGLTNAVIDPVMVCKGADEPLH
HHHHEEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
PENTVCYRETLVPKATVVTPNLFEAAQLSGLPRIETVEDMKEAAGRIHELGAQYVIVKGG
CCCCEEEHHHCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
RKIPHDYAVDVLYDGKTFELLESERIETTYTHGAGCTFSAAIAAELAKGRPVKDAIATAK
CCCCCCCEEEEEECCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHH
AFITAAIRHSFPLNEYVGPTHHGAYRRYMEQ
HHHHHHHHHCCCHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]