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The map label for this gene is kynA

Identifier: 138896805

GI number: 138896805

Start: 3270549

End: 3271391

Strand: Direct

Name: kynA

Synonym: GTNG_3168

Alternate gene names: 138896805

Gene position: 3270549-3271391 (Clockwise)

Preceding gene: 138896804

Following gene: 138896806

Centisome position: 92.12

GC content: 41.28

Gene sequence:

>843_bases
ATGCAAAATAAACAAAATCAATTCGAACTGGAGAAAGGCATTCATACAGATTTCCAAGAAGAAATGTCGTACGCAGGCTA
TCTTCAGCTTGATAAAATTTTATCGAGTCAACAGCGGTTATCTAATCATCATGATGAGATGCTATTTATCATTATTCACC
AAACAAGTGAACTTTGGATGAAACTCATTTTACATGAAATGGAAGCCGCTATTCAATGTATTTTAGATGACGATTTAGAA
CCATCCTTTAAAATGTTTGCCCGTATCTCAAGAATCCAACAACAACTCATTCAATCATGGAGCGTCCTTTCGACGCTGAC
TCCGTCAGAGTACATGGAATTTCGTGAATGTCTAGGCCATGCTTCCGGGTTCCAGTCTTATCAAAACCGTTTAATCGAAT
TTGCACTTGGGCAGAAAAATGCACATGTTTTGCCTGTTTTCCAACACGATCCGGAAATTTATGAAAAGATGACAAGAGCA
CTTCACTCCCCGAGCGTGTATGACGCAGCGATCAAAGCATTGGCCGTCCGGGGGCTGCCTATCGATGAAGACGTTCTTCA
TCGAGATTACTCACAAACCTACCAGCCAAATGCTAGCGTGGAAGAAGCATGGTTGACGGTATATCGAAATGTTGATCGAT
ATTGGGATTTATATGAGCTAGCCGAAAAGCTAGTAGATATCGGCAGCCAACAACAAACATGGCGTTACATGCACATGAAT
ACAGTGGAACGAATTATTGGCTACAAAAAAGGAACCGGAGGATCATCGGGCGTCTCCTACTTAAAAAAATCGCTCGATCG
CTCGTTCTTTCCTGAGCTATGGACATTAAGAACAAAACTATAG

Upstream 100 bases:

>100_bases
ATACCATAACGCAACTCCTTCTACACCATCCGATGAAACAGTCACTAGCGCGAATCAATGATCGTATCAATCTACCATTC
TACGAAAAGGGTGAGAACAT

Downstream 100 bases:

>100_bases
ATTCAGAGAACTTCAGGAGGCAAAATGATGAATCCATGGATCGATATCTCCCAACGACTTGATGAGCATATTCCAGTATG
GCCAGGCGATACACCTTTTT

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MQNKQNQFELEKGIHTDFQEEMSYAGYLQLDKILSSQQRLSNHHDEMLFIIIHQTSELWMKLILHEMEAAIQCILDDDLE
PSFKMFARISRIQQQLIQSWSVLSTLTPSEYMEFRECLGHASGFQSYQNRLIEFALGQKNAHVLPVFQHDPEIYEKMTRA
LHSPSVYDAAIKALAVRGLPIDEDVLHRDYSQTYQPNASVEEAWLTVYRNVDRYWDLYELAEKLVDIGSQQQTWRYMHMN
TVERIIGYKKGTGGSSGVSYLKKSLDRSFFPELWTLRTKL

Sequences:

>Translated_280_residues
MQNKQNQFELEKGIHTDFQEEMSYAGYLQLDKILSSQQRLSNHHDEMLFIIIHQTSELWMKLILHEMEAAIQCILDDDLE
PSFKMFARISRIQQQLIQSWSVLSTLTPSEYMEFRECLGHASGFQSYQNRLIEFALGQKNAHVLPVFQHDPEIYEKMTRA
LHSPSVYDAAIKALAVRGLPIDEDVLHRDYSQTYQPNASVEEAWLTVYRNVDRYWDLYELAEKLVDIGSQQQTWRYMHMN
TVERIIGYKKGTGGSSGVSYLKKSLDRSFFPELWTLRTKL
>Mature_280_residues
MQNKQNQFELEKGIHTDFQEEMSYAGYLQLDKILSSQQRLSNHHDEMLFIIIHQTSELWMKLILHEMEAAIQCILDDDLE
PSFKMFARISRIQQQLIQSWSVLSTLTPSEYMEFRECLGHASGFQSYQNRLIEFALGQKNAHVLPVFQHDPEIYEKMTRA
LHSPSVYDAAIKALAVRGLPIDEDVLHRDYSQTYQPNASVEEAWLTVYRNVDRYWDLYELAEKLVDIGSQQQTWRYMHMN
TVERIIGYKKGTGGSSGVSYLKKSLDRSFFPELWTLRTKL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=138, Percent_Identity=36.231884057971, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI32564651, Length=126, Percent_Identity=37.3015873015873, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=126, Percent_Identity=37.3015873015873, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17530891, Length=332, Percent_Identity=31.6265060240964, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_GEOTN (A4IT59)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001127258.1
- ProteinModelPortal:   A4IT59
- SMR:   A4IT59
- STRING:   A4IT59
- GeneID:   4968094
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_3168
- NMPDR:   fig|420246.5.peg.3031
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   HWELYEL
- ProtClustDB:   CLSK2787298
- BioCyc:   GTHE420246:GTNG_3168-MONOMER
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 32824; Mature: 32824

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: BINDING 111-111 BINDING 115-115 BINDING 122-122 BINDING 252-252

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKQNQFELEKGIHTDFQEEMSYAGYLQLDKILSSQQRLSNHHDEMLFIIIHQTSELWM
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KLILHEMEAAIQCILDDDLEPSFKMFARISRIQQQLIQSWSVLSTLTPSEYMEFRECLGH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ASGFQSYQNRLIEFALGQKNAHVLPVFQHDPEIYEKMTRALHSPSVYDAAIKALAVRGLP
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
IDEDVLHRDYSQTYQPNASVEEAWLTVYRNVDRYWDLYELAEKLVDIGSQQQTWRYMHMN
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TVERIIGYKKGTGGSSGVSYLKKSLDRSFFPELWTLRTKL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MQNKQNQFELEKGIHTDFQEEMSYAGYLQLDKILSSQQRLSNHHDEMLFIIIHQTSELWM
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KLILHEMEAAIQCILDDDLEPSFKMFARISRIQQQLIQSWSVLSTLTPSEYMEFRECLGH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ASGFQSYQNRLIEFALGQKNAHVLPVFQHDPEIYEKMTRALHSPSVYDAAIKALAVRGLP
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
IDEDVLHRDYSQTYQPNASVEEAWLTVYRNVDRYWDLYELAEKLVDIGSQQQTWRYMHMN
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TVERIIGYKKGTGGSSGVSYLKKSLDRSFFPELWTLRTKL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA