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The map label for this gene is nbaC

Identifier: 138896794

GI number: 138896794

Start: 3258581

End: 3259126

Strand: Reverse

Name: nbaC

Synonym: GTNG_3157

Alternate gene names: NA

Gene position: 3259126-3258581 (Counterclockwise)

Preceding gene: 138896795

Following gene: 138896793

Centisome position: 91.8

GC content: 50.92

Gene sequence:

>546_bases
ATGATTACGAAGAGTATCCAAAAACCGATCAATCTGTGGAAGTTCATCGAGGAGCACAAGGATCAGTTGAAACCACCGGT
TAACAACAAGGTGATCTGGAAGGATGCCGAGATCATGGTGATGTTGCTCGGGGGTCCTAACAAACGGCGTGACTTTCACG
TCGATCCGTCGGAAGAGCTTTTTTATCAGCTAAAGGGCGACTGCTACGTGGAAATCATTAACAACGAAGGGAAGCGCGAA
GTCATCACAGTTCGAGAAGGGGAGATGTTTCTCCTGCCGCCAAATGTGCCGCACTCGCCTCACCGCGTGGCCGACACGAT
CGGCATTGTCATCGAGCGCAACCGGAAGAAGGGAGAGCTAGAGAGCTTCGTTTGGTACTGCGACAAGTGCGATCATATGA
TGCACCGCGTTACTATTCAACTAACCAACATCGAGGTGCAGGTAAAACAGGCGATCGAAGAGTTCAACAGTAGCCTAGAG
CTACGCACTTGCAAGAACTGCGGATACGTCATGCCGCCGGAAGCGAGTGAATGGAAATGCGAGTAG

Upstream 100 bases:

>100_bases
GGCGGGTTCGGGTGTTGCTCTACGAGATTCCGTCCACCCACTGGATGGTAGGAGATCAGGCCAAAAACACACTATCAAAA
CATATGGAGGAGTGAGAGAG

Downstream 100 bases:

>100_bases
ACTTCCACACCCATATTATTCCGGAAGACCTGCCCGACTTTACCCAGCGGTATCAGGGTGACCGTTGGCCAGTGCTTAAG
CGCACCTGTGCCTGCGGAGC

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MITKSIQKPINLWKFIEEHKDQLKPPVNNKVIWKDAEIMVMLLGGPNKRRDFHVDPSEELFYQLKGDCYVEIINNEGKRE
VITVREGEMFLLPPNVPHSPHRVADTIGIVIERNRKKGELESFVWYCDKCDHMMHRVTIQLTNIEVQVKQAIEEFNSSLE
LRTCKNCGYVMPPEASEWKCE

Sequences:

>Translated_181_residues
MITKSIQKPINLWKFIEEHKDQLKPPVNNKVIWKDAEIMVMLLGGPNKRRDFHVDPSEELFYQLKGDCYVEIINNEGKRE
VITVREGEMFLLPPNVPHSPHRVADTIGIVIERNRKKGELESFVWYCDKCDHMMHRVTIQLTNIEVQVKQAIEEFNSSLE
LRTCKNCGYVMPPEASEWKCE
>Mature_181_residues
MITKSIQKPINLWKFIEEHKDQLKPPVNNKVIWKDAEIMVMLLGGPNKRRDFHVDPSEELFYQLKGDCYVEIINNEGKRE
VITVREGEMFLLPPNVPHSPHRVADTIGIVIERNRKKGELESFVWYCDKCDHMMHRVTIQLTNIEVQVKQAIEEFNSSLE
LRTCKNCGYVMPPEASEWKCE

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family [H]

Homologues:

Organism=Homo sapiens, GI188497625, Length=160, Percent_Identity=35.625, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562218, Length=156, Percent_Identity=34.6153846153846, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322485, Length=162, Percent_Identity=43.2098765432099, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710 [H]

Pfam domain/function: PF06052 3-HAO [H]

EC number: =1.13.11.6 [H]

Molecular weight: Translated: 21210; Mature: 21210

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKSIQKPINLWKFIEEHKDQLKPPVNNKVIWKDAEIMVMLLGGPNKRRDFHVDPSEEL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCCCEECCCHHHH
FYQLKGDCYVEIINNEGKREVITVREGEMFLLPPNVPHSPHRVADTIGIVIERNRKKGEL
HEEECCCEEEEEECCCCCEEEEEEECCCEEEECCCCCCCCHHHHHHEEEEEECCCCCCCH
ESFVWYCDKCDHMMHRVTIQLTNIEVQVKQAIEEFNSSLELRTCKNCGYVMPPEASEWKC
HHHHHHHHHHHHHHEEEEEEEECEEEHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCC
E
C
>Mature Secondary Structure
MITKSIQKPINLWKFIEEHKDQLKPPVNNKVIWKDAEIMVMLLGGPNKRRDFHVDPSEEL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCCCEECCCHHHH
FYQLKGDCYVEIINNEGKREVITVREGEMFLLPPNVPHSPHRVADTIGIVIERNRKKGEL
HEEECCCEEEEEECCCCCEEEEEEECCCEEEECCCCCCCCHHHHHHEEEEEECCCCCCCH
ESFVWYCDKCDHMMHRVTIQLTNIEVQVKQAIEEFNSSLELRTCKNCGYVMPPEASEWKC
HHHHHHHHHHHHHHEEEEEEEECEEEHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA