Click here to switch to the map view.

The map label for this gene is gdh [H]

Identifier: 138896785

GI number: 138896785

Start: 3249707

End: 3251074

Strand: Direct

Name: gdh [H]

Synonym: GTNG_3148

Alternate gene names: 138896785

Gene position: 3249707-3251074 (Clockwise)

Preceding gene: 138896781

Following gene: 138896786

Centisome position: 91.53

GC content: 41.67

Gene sequence:

>1368_bases
ATGACAACTGCCGTAAAAAGTCCATCAAAGGCAAAAGAGTATATCGATTCTGTATATCATCAACTTCAAGATAAATACGG
TTATCAACCAGAATTTTTACAAGCCGTAAAAGAAGTATTTTCCACATTAGTTCCCGTATTTGAACAACATCCAGAATACA
TTGAGCATAATATTCTTTCACGAATCGTAGAACCTGATCGCATCATCACTTTCCGTGTCACATGGCAAGATGATCAAAAT
CGAGTTCATGTCAACCGCGGTTATCGTGTCCAGTTTAACAATGTTGTCGGTCCTTATAAAGGTGGTTTACGCTTCCATCC
AACAGTAAACGAATCGATCATGAAATTTTTAGCATTTGAACAAATTTTTAAAAACGCATTAACTGGCCTGCCCATTGGCG
GTGCAAAAGGCGGCTCTGATTTTGACCCAAAAGGAAAATCCGATACAGAAATCATGCGTTTCTGCCAAGCATTCATGACA
GAGTTATATCGTCACATCGGTCCTGATGTCGATGTTCCTGCTGGAGATATTGGCGTAGGCGCCCGTGAAATCGGTTATTT
ATGGGGACAGTATAAACGCATAAAAGCAATGCATGAAGCGGGTATTCTTACTGGCAAACAACCAGGTTATGGCGGTTCTT
TAGTTCGCAAAGAAGCAACAGGATACGGACTCATTTACTTTGTAGAGGAAATGTTACGTGATGTTAATGATTCTCTTGAA
GGAAAAACGGTGGTTGTTTCTGGATCTGGAAATGTTGCTATTTATGCGATGGAAAAAGCACAACAATTAGGAGCGAAAGT
GGTCGCTTGCTCTGATTCCAATGGTTATGTTTACGATCCAGATGGCATTGATTTAAATGCTATAAAAGAAATCAAAGAAG
TGAAAGGCGAACGAATGAACAACTATGTGAAGTATCGTCCAAAAGCGACCTATACCGAGGGTTGCAAAGGCATTTGGACC
ATTCCATGCGACATCGCTCTTCCATGCGCCACACAAAACGAAATTGACGGAGAATCTGCACGGATTTTAATTGCGAACGG
AGTGAAAGTGGTCGCAGAAGGTGCGAACATGCCTTCCACTCCTGAAGCAATCGATGAATATTTATCCAACGGTGTATTAT
TCGGACCTGCGAAAGCAGCCAATGCAGGTGGGGTGGCCACTTCCGCATTAGAAATGGCACAAAATTCAAGTCGCATCTAC
TGGTCCTTTAATGAAGTCGACGAAAAGCTGCGTGACATTATGAAACACATTTATCAAACAAGTAAAGAATGCGCAGAAAA
ATACGGTTCCCCTGGAAACCTCATGGTCGGTGCGAATATTGCCGGATTTATCAAAGTTGCTAATGGAATGATTGCTGAAG
GGGTCTAA

Upstream 100 bases:

>100_bases
TTACCAATTTATTTTCCCCTGGTAAAAAAATAATGATTGAATTGTAAAAAAAATCATAATACCATTTTCTCGTAAGCTTT
TTAGGGGAGGGAGAACGACC

Downstream 100 bases:

>100_bases
TGTTCATTTGATATGGGGGAGTTTTTACAAAGGGGGGCATCAATAAAACGACAAAAGCCAATTGAAATGGGCTTAAAAGT
TCATTTCAATTGGCTTTTTT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTTAVKSPSKAKEYIDSVYHQLQDKYGYQPEFLQAVKEVFSTLVPVFEQHPEYIEHNILSRIVEPDRIITFRVTWQDDQN
RVHVNRGYRVQFNNVVGPYKGGLRFHPTVNESIMKFLAFEQIFKNALTGLPIGGAKGGSDFDPKGKSDTEIMRFCQAFMT
ELYRHIGPDVDVPAGDIGVGAREIGYLWGQYKRIKAMHEAGILTGKQPGYGGSLVRKEATGYGLIYFVEEMLRDVNDSLE
GKTVVVSGSGNVAIYAMEKAQQLGAKVVACSDSNGYVYDPDGIDLNAIKEIKEVKGERMNNYVKYRPKATYTEGCKGIWT
IPCDIALPCATQNEIDGESARILIANGVKVVAEGANMPSTPEAIDEYLSNGVLFGPAKAANAGGVATSALEMAQNSSRIY
WSFNEVDEKLRDIMKHIYQTSKECAEKYGSPGNLMVGANIAGFIKVANGMIAEGV

Sequences:

>Translated_455_residues
MTTAVKSPSKAKEYIDSVYHQLQDKYGYQPEFLQAVKEVFSTLVPVFEQHPEYIEHNILSRIVEPDRIITFRVTWQDDQN
RVHVNRGYRVQFNNVVGPYKGGLRFHPTVNESIMKFLAFEQIFKNALTGLPIGGAKGGSDFDPKGKSDTEIMRFCQAFMT
ELYRHIGPDVDVPAGDIGVGAREIGYLWGQYKRIKAMHEAGILTGKQPGYGGSLVRKEATGYGLIYFVEEMLRDVNDSLE
GKTVVVSGSGNVAIYAMEKAQQLGAKVVACSDSNGYVYDPDGIDLNAIKEIKEVKGERMNNYVKYRPKATYTEGCKGIWT
IPCDIALPCATQNEIDGESARILIANGVKVVAEGANMPSTPEAIDEYLSNGVLFGPAKAANAGGVATSALEMAQNSSRIY
WSFNEVDEKLRDIMKHIYQTSKECAEKYGSPGNLMVGANIAGFIKVANGMIAEGV
>Mature_454_residues
TTAVKSPSKAKEYIDSVYHQLQDKYGYQPEFLQAVKEVFSTLVPVFEQHPEYIEHNILSRIVEPDRIITFRVTWQDDQNR
VHVNRGYRVQFNNVVGPYKGGLRFHPTVNESIMKFLAFEQIFKNALTGLPIGGAKGGSDFDPKGKSDTEIMRFCQAFMTE
LYRHIGPDVDVPAGDIGVGAREIGYLWGQYKRIKAMHEAGILTGKQPGYGGSLVRKEATGYGLIYFVEEMLRDVNDSLEG
KTVVVSGSGNVAIYAMEKAQQLGAKVVACSDSNGYVYDPDGIDLNAIKEIKEVKGERMNNYVKYRPKATYTEGCKGIWTI
PCDIALPCATQNEIDGESARILIANGVKVVAEGANMPSTPEAIDEYLSNGVLFGPAKAANAGGVATSALEMAQNSSRIYW
SFNEVDEKLRDIMKHIYQTSKECAEKYGSPGNLMVGANIAGFIKVANGMIAEGV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=388, Percent_Identity=31.9587628865979, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4885281, Length=388, Percent_Identity=31.4432989690722, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1788059, Length=443, Percent_Identity=55.3047404063205, Blast_Score=497, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17544676, Length=358, Percent_Identity=30.4469273743017, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324951, Length=453, Percent_Identity=51.4348785871965, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319256, Length=455, Percent_Identity=50.3296703296703, Blast_Score=399, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24649283, Length=356, Percent_Identity=34.5505617977528, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45553475, Length=384, Percent_Identity=30.7291666666667, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45549226, Length=357, Percent_Identity=31.3725490196078, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24649460, Length=292, Percent_Identity=31.8493150684932, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 50082; Mature: 49950

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAVKSPSKAKEYIDSVYHQLQDKYGYQPEFLQAVKEVFSTLVPVFEQHPEYIEHNILS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RIVEPDRIITFRVTWQDDQNRVHVNRGYRVQFNNVVGPYKGGLRFHPTVNESIMKFLAFE
HHCCCCEEEEEEEEEECCCCEEEECCCEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHH
QIFKNALTGLPIGGAKGGSDFDPKGKSDTEIMRFCQAFMTELYRHIGPDVDVPAGDIGVG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AREIGYLWGQYKRIKAMHEAGILTGKQPGYGGSLVRKEATGYGLIYFVEEMLRDVNDSLE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
GKTVVVSGSGNVAIYAMEKAQQLGAKVVACSDSNGYVYDPDGIDLNAIKEIKEVKGERMN
CCEEEEECCCCEEEEEEHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHC
NYVKYRPKATYTEGCKGIWTIPCDIALPCATQNEIDGESARILIANGVKVVAEGANMPST
CEEEECCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCEEEEECCEEEEEECCCCCCC
PEAIDEYLSNGVLFGPAKAANAGGVATSALEMAQNSSRIYWSFNEVDEKLRDIMKHIYQT
HHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHH
SKECAEKYGSPGNLMVGANIAGFIKVANGMIAEGV
HHHHHHHCCCCCCEEECCCHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TTAVKSPSKAKEYIDSVYHQLQDKYGYQPEFLQAVKEVFSTLVPVFEQHPEYIEHNILS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RIVEPDRIITFRVTWQDDQNRVHVNRGYRVQFNNVVGPYKGGLRFHPTVNESIMKFLAFE
HHCCCCEEEEEEEEEECCCCEEEECCCEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHH
QIFKNALTGLPIGGAKGGSDFDPKGKSDTEIMRFCQAFMTELYRHIGPDVDVPAGDIGVG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AREIGYLWGQYKRIKAMHEAGILTGKQPGYGGSLVRKEATGYGLIYFVEEMLRDVNDSLE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
GKTVVVSGSGNVAIYAMEKAQQLGAKVVACSDSNGYVYDPDGIDLNAIKEIKEVKGERMN
CCEEEEECCCCEEEEEEHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHC
NYVKYRPKATYTEGCKGIWTIPCDIALPCATQNEIDGESARILIANGVKVVAEGANMPST
CEEEECCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCEEEEECCEEEEEECCCCCCC
PEAIDEYLSNGVLFGPAKAANAGGVATSALEMAQNSSRIYWSFNEVDEKLRDIMKHIYQT
HHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHH
SKECAEKYGSPGNLMVGANIAGFIKVANGMIAEGV
HHHHHHHCCCCCCEEECCCHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]