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The map label for this gene is sppA [H]

Identifier: 138896331

GI number: 138896331

Start: 2802256

End: 2803281

Strand: Reverse

Name: sppA [H]

Synonym: GTNG_2694

Alternate gene names: 138896331

Gene position: 2803281-2802256 (Counterclockwise)

Preceding gene: 138896333

Following gene: 138896330

Centisome position: 78.96

GC content: 47.47

Gene sequence:

>1026_bases
ATGCAAAGGGGGAAGAAAATGAATCGAAAACGGTGGACGGCGTTGGCGATTGCTGCCGCGTTATTTATTATTTCTGTGCT
TGTTAATGCCGTTGGTATCTTGCTGTCTGATAAGTCCGAAACATGGTCGAAAAATTGGTTGTCGCTTATGGAAGATTCAT
TTAGCGAGGAAGTGATCGAAGACGGCGATCCGTTGAAAAAAATCGTTGTCTTGGAGGTGAACGGTGTCATTGAAGATACG
GGCGAAGCGGAAACGTTCTTTTCCTCGTCGTTTTATAATCATCAAGCGTTTTTGAAAATGATTAAACAGGTGAAAGAAGA
TGACAGCGTCAAGGCGATCGTATTGCGCATCAACTCGCCGGGCGGCGGAGTCGTTGAAAGCGCGGAAGTTCATAACCAGC
TGTTGAAATTGAAAAAAGAGACGAAGAAGCCTATTTATGTGTCGATGGGAGCGATGGCAGCCTCCGGTGGCTATTACATC
GCCACAGCGGGTGATAAACTTTTTGCCAGCCCGGAGACGATCACGGGTTCGATCGGCGTCATTATGCAGAGCATCAATTA
CGAAGGGTTGGCGAAAAAATACGGCGTCGAACTCGTCACGATCAAAAGCGGCCCATACAAAGACATCATGAATCCAGCGC
GCAAAATGACGGATGCGGAGCAGGAGATTTTGCAACGGCTGATCAACCAATCGTATGAGGGGTTTGTCGATGTCATTGTT
GAAGGAAGAAAGTTGTCGGAAGAAGCGGTGCGCAAACTGGCTGATGGCCGCATTTACAACGGCCGCCAAGCGAAAGCGCT
CCAGTTGATTGATGAGTTTGGCTATTTGGATGATACCATTGCAGCACTGAAAAAAGAACATCGGCTTTCCGGTGCTCAAG
TCGTGAAATATGTCAGTGATACTCCGTGGAGTTCATTGTTTGGCGTGATATCGAACAATGCTAAGCCAGAAACGGAAGCG
TCCGAGCTCATTCGCTTGTTGTCGCGTCCGTCATCGCCACGGCTTATGTATTTATTTAGTGAGTAA

Upstream 100 bases:

>100_bases
CCATGTCCATCTTTGCGCCCTCCTATTGGCATCATGCTTAAACCGATGTACAATGAATATTGTACCACGTTTTCCATGAT
TATAAAAATATGGACAGTCC

Downstream 100 bases:

>100_bases
AGGAAGTGGGAAGATGACTGATACGCAAGCCATGGCGCCGTCTGCAGCCGAAAGCCTGCCGGTGGAAACAGCCCCCCGCT
ACGGCGGGTTTTGGCTTCGC

Product: Signal peptide peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQRGKKMNRKRWTALAIAAALFIISVLVNAVGILLSDKSETWSKNWLSLMEDSFSEEVIEDGDPLKKIVVLEVNGVIEDT
GEAETFFSSSFYNHQAFLKMIKQVKEDDSVKAIVLRINSPGGGVVESAEVHNQLLKLKKETKKPIYVSMGAMAASGGYYI
ATAGDKLFASPETITGSIGVIMQSINYEGLAKKYGVELVTIKSGPYKDIMNPARKMTDAEQEILQRLINQSYEGFVDVIV
EGRKLSEEAVRKLADGRIYNGRQAKALQLIDEFGYLDDTIAALKKEHRLSGAQVVKYVSDTPWSSLFGVISNNAKPETEA
SELIRLLSRPSSPRLMYLFSE

Sequences:

>Translated_341_residues
MQRGKKMNRKRWTALAIAAALFIISVLVNAVGILLSDKSETWSKNWLSLMEDSFSEEVIEDGDPLKKIVVLEVNGVIEDT
GEAETFFSSSFYNHQAFLKMIKQVKEDDSVKAIVLRINSPGGGVVESAEVHNQLLKLKKETKKPIYVSMGAMAASGGYYI
ATAGDKLFASPETITGSIGVIMQSINYEGLAKKYGVELVTIKSGPYKDIMNPARKMTDAEQEILQRLINQSYEGFVDVIV
EGRKLSEEAVRKLADGRIYNGRQAKALQLIDEFGYLDDTIAALKKEHRLSGAQVVKYVSDTPWSSLFGVISNNAKPETEA
SELIRLLSRPSSPRLMYLFSE
>Mature_341_residues
MQRGKKMNRKRWTALAIAAALFIISVLVNAVGILLSDKSETWSKNWLSLMEDSFSEEVIEDGDPLKKIVVLEVNGVIEDT
GEAETFFSSSFYNHQAFLKMIKQVKEDDSVKAIVLRINSPGGGVVESAEVHNQLLKLKKETKKPIYVSMGAMAASGGYYI
ATAGDKLFASPETITGSIGVIMQSINYEGLAKKYGVELVTIKSGPYKDIMNPARKMTDAEQEILQRLINQSYEGFVDVIV
EGRKLSEEAVRKLADGRIYNGRQAKALQLIDEFGYLDDTIAALKKEHRLSGAQVVKYVSDTPWSSLFGVISNNAKPETEA
SELIRLLSRPSSPRLMYLFSE

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=219, Percent_Identity=35.1598173515982, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1787527, Length=183, Percent_Identity=30.0546448087432, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 37802; Mature: 37802

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRGKKMNRKRWTALAIAAALFIISVLVNAVGILLSDKSETWSKNWLSLMEDSFSEEVIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DGDPLKKIVVLEVNGVIEDTGEAETFFSSSFYNHQAFLKMIKQVKEDDSVKAIVLRINSP
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEECC
GGGVVESAEVHNQLLKLKKETKKPIYVSMGAMAASGGYYIATAGDKLFASPETITGSIGV
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCEEECCCEEEEECCCCEECCCCCCCCHHHH
IMQSINYEGLAKKYGVELVTIKSGPYKDIMNPARKMTDAEQEILQRLINQSYEGFVDVIV
HHHHCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHH
EGRKLSEEAVRKLADGRIYNGRQAKALQLIDEFGYLDDTIAALKKEHRLSGAQVVKYVSD
CCCCCCHHHHHHHHCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCC
TPWSSLFGVISNNAKPETEASELIRLLSRPSSPRLMYLFSE
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MQRGKKMNRKRWTALAIAAALFIISVLVNAVGILLSDKSETWSKNWLSLMEDSFSEEVIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DGDPLKKIVVLEVNGVIEDTGEAETFFSSSFYNHQAFLKMIKQVKEDDSVKAIVLRINSP
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEECC
GGGVVESAEVHNQLLKLKKETKKPIYVSMGAMAASGGYYIATAGDKLFASPETITGSIGV
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCEEECCCEEEEECCCCEECCCCCCCCHHHH
IMQSINYEGLAKKYGVELVTIKSGPYKDIMNPARKMTDAEQEILQRLINQSYEGFVDVIV
HHHHCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHH
EGRKLSEEAVRKLADGRIYNGRQAKALQLIDEFGYLDDTIAALKKEHRLSGAQVVKYVSD
CCCCCCHHHHHHHHCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCC
TPWSSLFGVISNNAKPETEASELIRLLSRPSSPRLMYLFSE
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]