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The map label for this gene is argG [H]

Identifier: 138896319

GI number: 138896319

Start: 2792022

End: 2793242

Strand: Reverse

Name: argG [H]

Synonym: GTNG_2682

Alternate gene names: 138896319

Gene position: 2793242-2792022 (Counterclockwise)

Preceding gene: 138896322

Following gene: 138896318

Centisome position: 78.68

GC content: 51.92

Gene sequence:

>1221_bases
ATGGCAAATCCAAAATTGGTGCTGGCGTATTCCGGCGGTTTAGATACATCGGTGGCGATTAAGTGGTTGCAGGAGCGCGG
GTATGATGTGATCGCGTGCTGCTTGGACCTTGGAGAAGGGAAAGATCTCGATTTTGTGAAAGAAAAAGCGCTCAAAGTCG
GAGCAATCAAATCGTACGTCATCGACGTCAAAGACGAGTTTGCGAACGAGTACGCGCTCATCGCCTTGCAAGCAAACGCG
CTGTATGAAGGAAAATATCCGCTCGTCTCGGCACTGTCCCGTCCGCTCATTGCGAAAAAATTGGTGGAAATCGCCGAGCT
TGAAGGCGCGGTGGCAGTGGCTCACGGTTGCACGGGGAAAGGGAACGACCAAGTGCGTTTTGAAGTGTCAATCAAAGCAT
TGAATCCGGATTTGGACGTGATCGCGCCCGTTCGTGAATGGAGCTGGTCGCGTGAGGAAGAAATCGAATACGCGAAAAAA
CACGGCATTCCGATCCCGGTTGACCTTGATAGCCCGTTTTCGATCGACCAAAACTTATGGGGACGCAGCAACGAATGCGG
CATTTTGGAAGATCCGTGGGCTGCACCACCGGAAGAGGCGTACGAGCTGACAGCTTCGCTTGAGAATGCGCCGGACGTGC
CGGATGTTATCGAGATCGGCTTTGAGCAAGGCGTGCCGGTGACGCTAAACGGGAAAGCGTACCCGCTTGCACAGATGATT
TTGGAGCTGAACGCCATCGCCGGCAAGCATGGTGTCGGCCGCATCGACCATGTCGAGAATCGCCTTGTTGGCATTAAGTC
GCGTGAAGTGTACGAATGCCCAGGCGCCATGACATTGATCAAAGCGCATAAAGAGTTGGAAGACTTGACGCTTGTGCGGG
AAGTTGCCCATTTCAAGCCGCTCATCGAGCAAAAAATCGCCGAAGTCATTTACAACGGCCTCTGGTTCTCGCCGCTCAAA
GATGCGTTGGTCGCGTTTTTGAAAGAGACGCAGAAAAACGTGACCGGCGTTGTGCGTGTGAAGCTGTTTAAAGGCCATGC
GATCGTCGAAGGGCGCAAATCGCCATTCTCGCTCTATGATGAAAAATTGGCAACGTATACTTCAGAAGACGAATTTGATC
ATCAAGCAGCCGTTGGCTTCATTTCGCTGTACGGCTTGCCGACGAAAGTCAACAGCATTGTGAATAAGCAAAACAAATCA
TCGGTGTCGACGGGTCAATAA

Upstream 100 bases:

>100_bases
TATTGAAAAATCATTGGAAAGCTGATAAAGTGATAGTGTATTAGATTGAATATTTATTTATGTTTAAGTATATTTATGTG
AAAAAGAAAGGGGAACAACC

Downstream 100 bases:

>100_bases
AACATCGGGAAAAGGAAGGAGGAAGTCGCATTCCTCTGCGGCGTGATGTGTGAAAAAGCTTTGGGGTGGACGATTTACAA
AAACAGCGGAAGAATGGGTC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MANPKLVLAYSGGLDTSVAIKWLQERGYDVIACCLDLGEGKDLDFVKEKALKVGAIKSYVIDVKDEFANEYALIALQANA
LYEGKYPLVSALSRPLIAKKLVEIAELEGAVAVAHGCTGKGNDQVRFEVSIKALNPDLDVIAPVREWSWSREEEIEYAKK
HGIPIPVDLDSPFSIDQNLWGRSNECGILEDPWAAPPEEAYELTASLENAPDVPDVIEIGFEQGVPVTLNGKAYPLAQMI
LELNAIAGKHGVGRIDHVENRLVGIKSREVYECPGAMTLIKAHKELEDLTLVREVAHFKPLIEQKIAEVIYNGLWFSPLK
DALVAFLKETQKNVTGVVRVKLFKGHAIVEGRKSPFSLYDEKLATYTSEDEFDHQAAVGFISLYGLPTKVNSIVNKQNKS
SVSTGQ

Sequences:

>Translated_406_residues
MANPKLVLAYSGGLDTSVAIKWLQERGYDVIACCLDLGEGKDLDFVKEKALKVGAIKSYVIDVKDEFANEYALIALQANA
LYEGKYPLVSALSRPLIAKKLVEIAELEGAVAVAHGCTGKGNDQVRFEVSIKALNPDLDVIAPVREWSWSREEEIEYAKK
HGIPIPVDLDSPFSIDQNLWGRSNECGILEDPWAAPPEEAYELTASLENAPDVPDVIEIGFEQGVPVTLNGKAYPLAQMI
LELNAIAGKHGVGRIDHVENRLVGIKSREVYECPGAMTLIKAHKELEDLTLVREVAHFKPLIEQKIAEVIYNGLWFSPLK
DALVAFLKETQKNVTGVVRVKLFKGHAIVEGRKSPFSLYDEKLATYTSEDEFDHQAAVGFISLYGLPTKVNSIVNKQNKS
SVSTGQ
>Mature_405_residues
ANPKLVLAYSGGLDTSVAIKWLQERGYDVIACCLDLGEGKDLDFVKEKALKVGAIKSYVIDVKDEFANEYALIALQANAL
YEGKYPLVSALSRPLIAKKLVEIAELEGAVAVAHGCTGKGNDQVRFEVSIKALNPDLDVIAPVREWSWSREEEIEYAKKH
GIPIPVDLDSPFSIDQNLWGRSNECGILEDPWAAPPEEAYELTASLENAPDVPDVIEIGFEQGVPVTLNGKAYPLAQMIL
ELNAIAGKHGVGRIDHVENRLVGIKSREVYECPGAMTLIKAHKELEDLTLVREVAHFKPLIEQKIAEVIYNGLWFSPLKD
ALVAFLKETQKNVTGVVRVKLFKGHAIVEGRKSPFSLYDEKLATYTSEDEFDHQAAVGFISLYGLPTKVNSIVNKQNKSS
VSTGQ

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=394, Percent_Identity=45.1776649746193, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI16950633, Length=394, Percent_Identity=45.1776649746193, Blast_Score=321, Evalue=7e-88,
Organism=Escherichia coli, GI1789563, Length=419, Percent_Identity=26.9689737470167, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324514, Length=406, Percent_Identity=39.4088669950739, Blast_Score=283, Evalue=5e-77,
Organism=Drosophila melanogaster, GI21358151, Length=420, Percent_Identity=40.4761904761905, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44687; Mature: 44555

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPKLVLAYSGGLDTSVAIKWLQERGYDVIACCLDLGEGKDLDFVKEKALKVGAIKSYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHE
IDVKDEFANEYALIALQANALYEGKYPLVSALSRPLIAKKLVEIAELEGAVAVAHGCTGK
EECHHHHCCCEEEEEEEECEEECCCCHHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCCC
GNDQVRFEVSIKALNPDLDVIAPVREWSWSREEEIEYAKKHGIPIPVDLDSPFSIDQNLW
CCCEEEEEEEEEEECCCCCEEECHHHCCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHC
GRSNECGILEDPWAAPPEEAYELTASLENAPDVPDVIEIGFEQGVPVTLNGKAYPLAQMI
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCCHHHHHH
LELNAIAGKHGVGRIDHVENRLVGIKSREVYECPGAMTLIKAHKELEDLTLVREVAHFKP
HHHHHHCCCCCCCCHHHHHHHEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIEQKIAEVIYNGLWFSPLKDALVAFLKETQKNVTGVVRVKLFKGHAIVEGRKSPFSLYD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCEEECCCCCCHHHHH
EKLATYTSEDEFDHQAAVGFISLYGLPTKVNSIVNKQNKSSVSTGQ
HHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ANPKLVLAYSGGLDTSVAIKWLQERGYDVIACCLDLGEGKDLDFVKEKALKVGAIKSYV
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHE
IDVKDEFANEYALIALQANALYEGKYPLVSALSRPLIAKKLVEIAELEGAVAVAHGCTGK
EECHHHHCCCEEEEEEEECEEECCCCHHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCCC
GNDQVRFEVSIKALNPDLDVIAPVREWSWSREEEIEYAKKHGIPIPVDLDSPFSIDQNLW
CCCEEEEEEEEEEECCCCCEEECHHHCCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHC
GRSNECGILEDPWAAPPEEAYELTASLENAPDVPDVIEIGFEQGVPVTLNGKAYPLAQMI
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCCHHHHHH
LELNAIAGKHGVGRIDHVENRLVGIKSREVYECPGAMTLIKAHKELEDLTLVREVAHFKP
HHHHHHCCCCCCCCHHHHHHHEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIEQKIAEVIYNGLWFSPLKDALVAFLKETQKNVTGVVRVKLFKGHAIVEGRKSPFSLYD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCEEECCCCCCHHHHH
EKLATYTSEDEFDHQAAVGFISLYGLPTKVNSIVNKQNKSSVSTGQ
HHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA