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The map label for this gene is argH [H]

Identifier: 138896318

GI number: 138896318

Start: 2790593

End: 2791972

Strand: Reverse

Name: argH [H]

Synonym: GTNG_2681

Alternate gene names: 138896318

Gene position: 2791972-2790593 (Counterclockwise)

Preceding gene: 138896319

Following gene: 138896316

Centisome position: 78.64

GC content: 53.91

Gene sequence:

>1380_bases
GTGAAAAAGCTTTGGGGTGGACGATTTACAAAAACAGCGGAAGAATGGGTCGATGAGTTTGGCGCATCGATCCCGTTCGA
CCAAGAGCTCGTTGAAGAAGATATTGAAGGCAGCCTCGCTCATGTGACGATGCTCGGCGAGTGCGGTATTTTGCCGGCCG
AGGACGTCGAAAAAATAAAAGACGGGCTTCTACGCTTGCTCGAAAAAGCGAAGCGGGGAGAGCTGGAGTTTTCGGTCGCG
TATGAAGACATTCACTTAAACATCGAAAAAATGTTGATCGATGACATCGGCTCAGTCGGCGGCAAGTTGCATACCGGACG
GAGCCGGAACGACCAAGTGGCGACCGATATGCATCTATACTTGCGCAAGCGCGTCAAAGAGATTCTCAGCTTGATCCGCG
GGCTGCAGCGGGCGCTTGTGTCTCAAGCCGAGAAGCATGTCGAAACGATCATGCCGGGGTATACGCATTTGCAGCGGGCG
CAGCCGATTTCGTTCGCCCATCATCTGCTTGCGTATGTGTGGATGTTAGAACGTGACTATGAGCGCTTTTCCGAGTCGCT
GAAACGAATCAACCGCTCGCCGCTTGGCGCCGGGGCGCTCGCCGGCACGACGTTCCCGATCAACCGGCAGCGGACGGCGG
AGCTCCTTGGTTTTGAAGGCATTTACGAAAACAGCTTAGATGCTGTAAGCGATCGCGATTTTATCATCGAATTTCTAAGC
AACAGCTCGATGCTCATGATGCACTTATCGCGGCTGGCGGAGGAGCTCATCCTTTGGTCAAGCCAAGAGTTTCAGTTCGT
TGAGCTTGATGACGCGTTTGCGACCGGCAGCAGCATCATGCCGCAAAAGAAAAACCCGGACATGGCCGAGCTTATCCGCG
GCAAAACCGGGCGGGTCTACGGGCACCTAATGGCCTTGTTGACGGTGATGAAAGGGCTGCCGCTTGCCTACAACAAAGAT
ATGCAAGAAGATAAAGAAGGCATGTTCGATACGGTGAAGACGGTCATCGGTTCGTTGAAAATTTTCACCGGCATGATCGA
GACGATGAATGTGCGCGTGGATGCGATGGAGAAGGCGACAAAACAAGACTTTTCGAACGCTACGGAGCTCGCCGATTATC
TGGCGGCCAAAGGCATGCCGTTCCGCGAAGCGCATGAGGTCGTCGGCAAGCTCGTCTTGCATTGCATCGAACAAGGCGTT
TTTTTGGCCGATTTGCCGCTTGAGGTGTATAAGGAAGCGTCGCCGCTGTTTGAAAAAGACATTTATGACGCGTTGAATCC
GCGTACGGCGGTCAATCGCCGCAACAGCGCCGGCGGAACCGGTTTTGCGGAAGTGCGCGCGACGCTCGCCAAAGTGAAAG
AGAGACTAGGCACCCTGTAA

Upstream 100 bases:

>100_bases
AACAGCATTGTGAATAAGCAAAACAAATCATCGGTGTCGACGGGTCAATAAAACATCGGGAAAAGGAAGGAGGAAGTCGC
ATTCCTCTGCGGCGTGATGT

Downstream 100 bases:

>100_bases
CATGACGGGGTGCTCTTTTTTTGGACAGGGCCGGAACATGTGCGGTTTCTTTCTCTCTCTATGTGCATGAGTTTTGTTCG
TACCACTATTCTTTTGGTGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKKLWGGRFTKTAEEWVDEFGASIPFDQELVEEDIEGSLAHVTMLGECGILPAEDVEKIKDGLLRLLEKAKRGELEFSVA
YEDIHLNIEKMLIDDIGSVGGKLHTGRSRNDQVATDMHLYLRKRVKEILSLIRGLQRALVSQAEKHVETIMPGYTHLQRA
QPISFAHHLLAYVWMLERDYERFSESLKRINRSPLGAGALAGTTFPINRQRTAELLGFEGIYENSLDAVSDRDFIIEFLS
NSSMLMMHLSRLAEELILWSSQEFQFVELDDAFATGSSIMPQKKNPDMAELIRGKTGRVYGHLMALLTVMKGLPLAYNKD
MQEDKEGMFDTVKTVIGSLKIFTGMIETMNVRVDAMEKATKQDFSNATELADYLAAKGMPFREAHEVVGKLVLHCIEQGV
FLADLPLEVYKEASPLFEKDIYDALNPRTAVNRRNSAGGTGFAEVRATLAKVKERLGTL

Sequences:

>Translated_459_residues
MKKLWGGRFTKTAEEWVDEFGASIPFDQELVEEDIEGSLAHVTMLGECGILPAEDVEKIKDGLLRLLEKAKRGELEFSVA
YEDIHLNIEKMLIDDIGSVGGKLHTGRSRNDQVATDMHLYLRKRVKEILSLIRGLQRALVSQAEKHVETIMPGYTHLQRA
QPISFAHHLLAYVWMLERDYERFSESLKRINRSPLGAGALAGTTFPINRQRTAELLGFEGIYENSLDAVSDRDFIIEFLS
NSSMLMMHLSRLAEELILWSSQEFQFVELDDAFATGSSIMPQKKNPDMAELIRGKTGRVYGHLMALLTVMKGLPLAYNKD
MQEDKEGMFDTVKTVIGSLKIFTGMIETMNVRVDAMEKATKQDFSNATELADYLAAKGMPFREAHEVVGKLVLHCIEQGV
FLADLPLEVYKEASPLFEKDIYDALNPRTAVNRRNSAGGTGFAEVRATLAKVKERLGTL
>Mature_459_residues
MKKLWGGRFTKTAEEWVDEFGASIPFDQELVEEDIEGSLAHVTMLGECGILPAEDVEKIKDGLLRLLEKAKRGELEFSVA
YEDIHLNIEKMLIDDIGSVGGKLHTGRSRNDQVATDMHLYLRKRVKEILSLIRGLQRALVSQAEKHVETIMPGYTHLQRA
QPISFAHHLLAYVWMLERDYERFSESLKRINRSPLGAGALAGTTFPINRQRTAELLGFEGIYENSLDAVSDRDFIIEFLS
NSSMLMMHLSRLAEELILWSSQEFQFVELDDAFATGSSIMPQKKNPDMAELIRGKTGRVYGHLMALLTVMKGLPLAYNKD
MQEDKEGMFDTVKTVIGSLKIFTGMIETMNVRVDAMEKATKQDFSNATELADYLAAKGMPFREAHEVVGKLVLHCIEQGV
FLADLPLEVYKEASPLFEKDIYDALNPRTAVNRRNSAGGTGFAEVRATLAKVKERLGTL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=44.4933920704846, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=44.4933920704846, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=41.8502202643172, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=42.0704845814978, Blast_Score=351, Evalue=8e-97,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=48.7912087912088, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=44.1048034934498, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=41.1504424778761, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=41.1504424778761, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51609; Mature: 51609

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLWGGRFTKTAEEWVDEFGASIPFDQELVEEDIEGSLAHVTMLGECGILPAEDVEKIK
CCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHH
DGLLRLLEKAKRGELEFSVAYEDIHLNIEKMLIDDIGSVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
LRKRVKEILSLIRGLQRALVSQAEKHVETIMPGYTHLQRAQPISFAHHLLAYVWMLERDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFSESLKRINRSPLGAGALAGTTFPINRQRTAELLGFEGIYENSLDAVSDRDFIIEFLS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHCCCHHHCCHHHHHHHHC
NSSMLMMHLSRLAEELILWSSQEFQFVELDDAFATGSSIMPQKKNPDMAELIRGKTGRVY
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCCCCCCCCCHHHHHCCCCCHHH
GHLMALLTVMKGLPLAYNKDMQEDKEGMFDTVKTVIGSLKIFTGMIETMNVRVDAMEKAT
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQDFSNATELADYLAAKGMPFREAHEVVGKLVLHCIEQGVFLADLPLEVYKEASPLFEKD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCCHHHHHH
IYDALNPRTAVNRRNSAGGTGFAEVRATLAKVKERLGTL
HHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLWGGRFTKTAEEWVDEFGASIPFDQELVEEDIEGSLAHVTMLGECGILPAEDVEKIK
CCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHH
DGLLRLLEKAKRGELEFSVAYEDIHLNIEKMLIDDIGSVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
LRKRVKEILSLIRGLQRALVSQAEKHVETIMPGYTHLQRAQPISFAHHLLAYVWMLERDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFSESLKRINRSPLGAGALAGTTFPINRQRTAELLGFEGIYENSLDAVSDRDFIIEFLS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHCCCHHHCCHHHHHHHHC
NSSMLMMHLSRLAEELILWSSQEFQFVELDDAFATGSSIMPQKKNPDMAELIRGKTGRVY
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCCCCCCCCCHHHHHCCCCCHHH
GHLMALLTVMKGLPLAYNKDMQEDKEGMFDTVKTVIGSLKIFTGMIETMNVRVDAMEKAT
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQDFSNATELADYLAAKGMPFREAHEVVGKLVLHCIEQGVFLADLPLEVYKEASPLFEKD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCCHHHHHH
IYDALNPRTAVNRRNSAGGTGFAEVRATLAKVKERLGTL
HHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA