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The map label for this gene is thrS [H]

Identifier: 138896280

GI number: 138896280

Start: 2750027

End: 2751976

Strand: Reverse

Name: thrS [H]

Synonym: GTNG_2643

Alternate gene names: 138896280

Gene position: 2751976-2750027 (Counterclockwise)

Preceding gene: 138896281

Following gene: 138896279

Centisome position: 77.51

GC content: 50.77

Gene sequence:

>1950_bases
ATGCCAGACGTTATTCGCATTACGTTCCCGGACGGGGCGAAAAAGGAGTTTCCGAGCGGAACGTCAACTGAGGACATCGC
TGCCTCGATCAGTCCGGGATTGAAGAAAAAAGCGATTGCCGGGAAACTGAACGGCCGGTTTGTTGATTTACGCACGCCGC
TTCAAGAAGACGGCGAGCTTGTCATTATTACCCAGGACATGCCTGAGGCACTTGATATTTTGCGTCATAGCACCGCCCAT
TTAATGGCGCAAGCGATCAAGCGGCTGTATGACAACGTCAAGCTTGGCGTCGGCCCGGTCATTGAAAACGGCTTCTACTA
TGATATTGATATGGAACATAAGCTGACGCCGGATGATTTGCCGAAAATTGAGGCGGAAATGCGCAAAATCGTAAAGGAAA
ATCTTGACGTTGTTCGCAAAGAAGTGAGCCGCGACGAGGCGATTCGCCTGTATGAAAAAATTGGTGATCACTTGAAACTG
GAGCTCATCAACGATATTCCGGAAGGCGAGACGATTTCCATTTACGAGCAAGGCGAGTTTTTCGATCTTTGTCGGGGTGT
GCACGTGCCGTCGACCGGGAAAATCAAAGAGTTCAAGCTGCTCAGCATCTCGGGGGCCTACTGGCGCGGTGACAGAAACA
ACAAAATGCTGCAGCGTATTTACGGTACGGCGTTTTTCAAAAAAGAAGATCTGGACCATTATTTGCAGTTGCTCGAAGAG
GCGAAAGAGCGCGATCATCGCAAATTGGGCAAAGAGCTTGAGCTATTTACGACATCACAAAAAGTCGGACAAGGACTGCC
GCTTTGGTTGCCGAAAGGGGCGACGATCCGTCGCTTGATTGAACGGTACATTGTCGATAAAGAAATCGCCCTTGGTTATG
ATCATGTATATACGCCGGTGCTCGGTAGTGTGGAGCTGTATAAAACCTCAGGACACTGGGACCATTATAAAGAAAACATG
TTCCCACCGATGGAAATGGATAACGAAGAGCTCGTGCTGCGGCCGATGAACTGCCCGCACCATATGATGATTTATAAAAG
CAAGCTTCATAGCTACCGTGAGCTGCCGATCCGCATCGCCGAGCTCGGCACGATGCATCGCTACGAAATGTCCGGGGCGC
TTACTGGACTGCAGCGTGTCCGCGGCATGACGCTCAACGACGCCCATATTTTCGTGCGCCCGGATCAAATTAAAGACGAG
TTTAAGCGCGTCGTTAATTTGATTTTGGAAGTATACAAAGACTTTGGGCTGGACGAATATTCGTTCCGCCTGTCGTACCG
CGACCCACAAGATAAAGAAAAATATTACGACGACGACGAGATGTGGGAAAAGGCGCAACGCATGCTGCGCGAGGCGATGG
ATGAACTTGGCCTCGATTACTACGAAGCGGAAGGGGAAGCAGCGTTTTACGGACCGAAGCTCGATGTGCAAGTGCGCACG
GCACTCGGCAAAGATGAGACGCTGTCGACTGTACAGCTTGACTTCCTCTTGCCGGAGCGGTTTGACTTAACATATATCGG
CGAAGATGGAAAACCGCACCGCCCGGTCGTCATCCACCGCGGCGTTGTTTCCACGATGGAACGGTTTGTCGCCTTCTTGA
TCGAAGAATACAAAGGGGCATTTCCAACGTGGCTCGCCCCGGTGCAAGTGGAAGTCATCCCGGTATCGTCGGAAGCCCAT
CTCGATTATGCGTATGAAGTGAAACAAGCGCTGCAAGTAAACGGCTTCCGCGTCGAAGTCGACGAACGGGATGAAAAAAT
CGGCTATAAAATCCGCGAAGCGCAAATGCAAAAAATTCCTTATATGCTCGTTGTCGGCGACAAAGAAGCGGCCGAGCGAG
CGGTCAACGTCCGCCGCTACGGTGAAAAAGAAAGCGAGACTGTGGCGCTTGACAAGTTTATCGCGATGCTAGAAGAAGAT
GTGCGGCAAAAACGAGTGAAAAAACGATGA

Upstream 100 bases:

>100_bases
GTTTTTGCCATGGGAAGAAGGGTGGAACCACGACAAAAACTCGTCCCTTTATGAGGGAGGAGTTTTTTTATTTTGACATT
AAGGTAAAGGAGTGAACTTC

Downstream 100 bases:

>100_bases
GCCAACAGCGGCCCGTAGGCGGCATGCCCGCCTGCCGGGCTGCTTTTTTCAGGTGAACAGCTGCGCTGCCTCAGAAACGG
GAACACGAAGGGCAACAAAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MPDVIRITFPDGAKKEFPSGTSTEDIAASISPGLKKKAIAGKLNGRFVDLRTPLQEDGELVIITQDMPEALDILRHSTAH
LMAQAIKRLYDNVKLGVGPVIENGFYYDIDMEHKLTPDDLPKIEAEMRKIVKENLDVVRKEVSRDEAIRLYEKIGDHLKL
ELINDIPEGETISIYEQGEFFDLCRGVHVPSTGKIKEFKLLSISGAYWRGDRNNKMLQRIYGTAFFKKEDLDHYLQLLEE
AKERDHRKLGKELELFTTSQKVGQGLPLWLPKGATIRRLIERYIVDKEIALGYDHVYTPVLGSVELYKTSGHWDHYKENM
FPPMEMDNEELVLRPMNCPHHMMIYKSKLHSYRELPIRIAELGTMHRYEMSGALTGLQRVRGMTLNDAHIFVRPDQIKDE
FKRVVNLILEVYKDFGLDEYSFRLSYRDPQDKEKYYDDDEMWEKAQRMLREAMDELGLDYYEAEGEAAFYGPKLDVQVRT
ALGKDETLSTVQLDFLLPERFDLTYIGEDGKPHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVEVIPVSSEAH
LDYAYEVKQALQVNGFRVEVDERDEKIGYKIREAQMQKIPYMLVVGDKEAAERAVNVRRYGEKESETVALDKFIAMLEED
VRQKRVKKR

Sequences:

>Translated_649_residues
MPDVIRITFPDGAKKEFPSGTSTEDIAASISPGLKKKAIAGKLNGRFVDLRTPLQEDGELVIITQDMPEALDILRHSTAH
LMAQAIKRLYDNVKLGVGPVIENGFYYDIDMEHKLTPDDLPKIEAEMRKIVKENLDVVRKEVSRDEAIRLYEKIGDHLKL
ELINDIPEGETISIYEQGEFFDLCRGVHVPSTGKIKEFKLLSISGAYWRGDRNNKMLQRIYGTAFFKKEDLDHYLQLLEE
AKERDHRKLGKELELFTTSQKVGQGLPLWLPKGATIRRLIERYIVDKEIALGYDHVYTPVLGSVELYKTSGHWDHYKENM
FPPMEMDNEELVLRPMNCPHHMMIYKSKLHSYRELPIRIAELGTMHRYEMSGALTGLQRVRGMTLNDAHIFVRPDQIKDE
FKRVVNLILEVYKDFGLDEYSFRLSYRDPQDKEKYYDDDEMWEKAQRMLREAMDELGLDYYEAEGEAAFYGPKLDVQVRT
ALGKDETLSTVQLDFLLPERFDLTYIGEDGKPHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVEVIPVSSEAH
LDYAYEVKQALQVNGFRVEVDERDEKIGYKIREAQMQKIPYMLVVGDKEAAERAVNVRRYGEKESETVALDKFIAMLEED
VRQKRVKKR
>Mature_648_residues
PDVIRITFPDGAKKEFPSGTSTEDIAASISPGLKKKAIAGKLNGRFVDLRTPLQEDGELVIITQDMPEALDILRHSTAHL
MAQAIKRLYDNVKLGVGPVIENGFYYDIDMEHKLTPDDLPKIEAEMRKIVKENLDVVRKEVSRDEAIRLYEKIGDHLKLE
LINDIPEGETISIYEQGEFFDLCRGVHVPSTGKIKEFKLLSISGAYWRGDRNNKMLQRIYGTAFFKKEDLDHYLQLLEEA
KERDHRKLGKELELFTTSQKVGQGLPLWLPKGATIRRLIERYIVDKEIALGYDHVYTPVLGSVELYKTSGHWDHYKENMF
PPMEMDNEELVLRPMNCPHHMMIYKSKLHSYRELPIRIAELGTMHRYEMSGALTGLQRVRGMTLNDAHIFVRPDQIKDEF
KRVVNLILEVYKDFGLDEYSFRLSYRDPQDKEKYYDDDEMWEKAQRMLREAMDELGLDYYEAEGEAAFYGPKLDVQVRTA
LGKDETLSTVQLDFLLPERFDLTYIGEDGKPHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVEVIPVSSEAHL
DYAYEVKQALQVNGFRVEVDERDEKIGYKIREAQMQKIPYMLVVGDKEAAERAVNVRRYGEKESETVALDKFIAMLEEDV
RQKRVKKR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=634, Percent_Identity=38.9589905362776, Blast_Score=451, Evalue=1e-126,
Organism=Homo sapiens, GI38570111, Length=601, Percent_Identity=38.2695507487521, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI20070344, Length=637, Percent_Identity=36.4207221350078, Blast_Score=391, Evalue=1e-108,
Organism=Escherichia coli, GI1788013, Length=643, Percent_Identity=42.457231726283, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71984184, Length=635, Percent_Identity=38.8976377952756, Blast_Score=447, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984192, Length=635, Percent_Identity=38.8976377952756, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322112, Length=671, Percent_Identity=35.7675111773472, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=35.25, Blast_Score=252, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24583842, Length=638, Percent_Identity=38.5579937304075, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI28574141, Length=638, Percent_Identity=38.5579937304075, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583839, Length=638, Percent_Identity=38.5579937304075, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 75214; Mature: 75083

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00018 EF_HAND_1 ; PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDVIRITFPDGAKKEFPSGTSTEDIAASISPGLKKKAIAGKLNGRFVDLRTPLQEDGEL
CCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCCCCE
VIITQDMPEALDILRHSTAHLMAQAIKRLYDNVKLGVGPVIENGFYYDIDMEHKLTPDDL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEEEECCCCCCCCCCC
PKIEAEMRKIVKENLDVVRKEVSRDEAIRLYEKIGDHLKLELINDIPEGETISIYEQGEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCEEEEEECCCH
FDLCRGVHVPSTGKIKEFKLLSISGAYWRGDRNNKMLQRIYGTAFFKKEDLDHYLQLLEE
HHHHCCCCCCCCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKERDHRKLGKELELFTTSQKVGQGLPLWLPKGATIRRLIERYIVDKEIALGYDHVYTPV
HHHHHHHHHCCHHEEEECHHHHCCCCCEECCCCHHHHHHHHHHHCCCHHHCCCCHHHHCC
LGSVELYKTSGHWDHYKENMFPPMEMDNEELVLRPMNCPHHMMIYKSKLHSYRELPIRIA
CCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEE
ELGTMHRYEMSGALTGLQRVRGMTLNDAHIFVRPDQIKDEFKRVVNLILEVYKDFGLDEY
HHCCHHHHHHHHHHHHHHHHCCCEECCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCE
SFRLSYRDPQDKEKYYDDDEMWEKAQRMLREAMDELGLDYYEAEGEAAFYGPKLDVQVRT
EEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCEEEEE
ALGKDETLSTVQLDFLLPERFDLTYIGEDGKPHRPVVIHRGVVSTMERFVAFLIEEYKGA
CCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCC
FPTWLAPVQVEVIPVSSEAHLDYAYEVKQALQVNGFRVEVDERDEKIGYKIREAQMQKIP
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHCHHHHHHHHHHCC
YMLVVGDKEAAERAVNVRRYGEKESETVALDKFIAMLEEDVRQKRVKKR
EEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDVIRITFPDGAKKEFPSGTSTEDIAASISPGLKKKAIAGKLNGRFVDLRTPLQEDGEL
CCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCCCCE
VIITQDMPEALDILRHSTAHLMAQAIKRLYDNVKLGVGPVIENGFYYDIDMEHKLTPDDL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEEEECCCCCCCCCCC
PKIEAEMRKIVKENLDVVRKEVSRDEAIRLYEKIGDHLKLELINDIPEGETISIYEQGEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCEEEEEECCCH
FDLCRGVHVPSTGKIKEFKLLSISGAYWRGDRNNKMLQRIYGTAFFKKEDLDHYLQLLEE
HHHHCCCCCCCCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKERDHRKLGKELELFTTSQKVGQGLPLWLPKGATIRRLIERYIVDKEIALGYDHVYTPV
HHHHHHHHHCCHHEEEECHHHHCCCCCEECCCCHHHHHHHHHHHCCCHHHCCCCHHHHCC
LGSVELYKTSGHWDHYKENMFPPMEMDNEELVLRPMNCPHHMMIYKSKLHSYRELPIRIA
CCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEE
ELGTMHRYEMSGALTGLQRVRGMTLNDAHIFVRPDQIKDEFKRVVNLILEVYKDFGLDEY
HHCCHHHHHHHHHHHHHHHHCCCEECCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCE
SFRLSYRDPQDKEKYYDDDEMWEKAQRMLREAMDELGLDYYEAEGEAAFYGPKLDVQVRT
EEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCEEEEE
ALGKDETLSTVQLDFLLPERFDLTYIGEDGKPHRPVVIHRGVVSTMERFVAFLIEEYKGA
CCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCC
FPTWLAPVQVEVIPVSSEAHLDYAYEVKQALQVNGFRVEVDERDEKIGYKIREAQMQKIP
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHCHHHHHHHHHHCC
YMLVVGDKEAAERAVNVRRYGEKESETVALDKFIAMLEEDVRQKRVKKR
EEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA