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The map label for this gene is sdhA [H]

Identifier: 138896237

GI number: 138896237

Start: 2708116

End: 2709873

Strand: Reverse

Name: sdhA [H]

Synonym: GTNG_2600

Alternate gene names: 138896237

Gene position: 2709873-2708116 (Counterclockwise)

Preceding gene: 138896238

Following gene: 138896236

Centisome position: 76.33

GC content: 51.25

Gene sequence:

>1758_bases
ATGAAAAAAGGAAAAATCATCGTTGTTGGCGGCGGATTGGCCGGCTTGATGGCCACGATTAAAATCGCCGAAGCAGGAGT
GCCTGTCGAGTTGTTTTCACTCGTTCCAGTAAAGCGTTCTCACTCCGTCTGTGCCCAAGGAGGCATTAACGGAGCGGTCA
ATACGAAAGGTGAGGGTGACTCGCCGTGGGAACATTTTGACGATACCGTCTACGGCGGCGACTTTTTGGCGAACCAGCCT
CCGGTCAAAGCGATGTGTGAGGCGGCGCCGGGCATCATTTACATGCTCGATCGGATGGGTGTCATGTTCAACCGCACGCC
GGAAGGATTGCTCGATTTCCGTCGTTTCGGGGGAACGCAGCATCACCGCACTGCTTACGCTGGAGCAACGACTGGTCAGC
AAATTTTGTATGCGCTTGATGAGCAAGTGCGTCGCCATGAAGTAGCAGGCCTTGTCACGAAATATGAGCATTGGGAATTT
TTGGGTGTTGTTTTAGATGATGAACAAATTTGCCGCGGCATCGTCGCACAAGACTTGCGGTCCATGGAAATTAAAGCGTT
TCCGGCTGATGCGGTCATTTTGGCGACCGGTGGTCCGGGGATCATCTTTGGAAAATCGACGAACTCGGTCATCAATACTG
GTTCGGCCGCATCGATCGCTTACCAACAAGGTGTCTATTACGCAAACGGTGAGTTTATCCAAATTCATCCGACCGCGATT
CCGGGCGATGACAAGCTTCGGTTGATGAGCGAATCGGCGCGCGGAGAGGGCGGACGCGTCTGGACGTACAAAGACGGAAA
ACCGTGGTACTTCCTCGAAGAAAAGTATCCGGCTTACGGAAACTTAGTGCCACGCGACATCGCCGCTCGGGAAATTTTCC
ATGTGTGCGTCGACTTGAAGCTTGGCATTAACGGCGAAAACATGGTGTATTTGGATCTTTCCCATAAAGATCCGAAAGAG
CTGGATGTTAAGCTTGGCGGTATTATTGAAATTTATGAGAAATTCATGGGCGAAGATCCGCGCAAAGTGCCGATGAAAGT
GTTCCCGGCCGTTCACTATTCGATGGGCGGTTTATGGGTCGATTATGATCAAATGACGAACATTAAAGGGTTGTTTGCCG
CAGGTGAGTGCGATTATTCTATTCACGGCGCGAACCGCCTTGGTGCGAACTCGCTGCTCTCAGCTATTTATGGCGGAATG
GTCGCCGGCCCGAATGCTGTTCGTTACATCCGCGGCCTTGAAAAATCGGCCGATGCGTTGCCGTCGACGCTCTTTGACAG
CTATGTCAAACAAGAACAAGAAAAATGGGAAAACATCCTGTCGATGGACGGCACGGAAAACGCTTATGTGCTGCATAAAG
AACTCGGCGAATGGATGACAGCGAACGTGACGATCGTCCGCTACAACGACCGGCTGCTGAAGACGGACGAAAAAATTCAA
GAGCTGATGGAGCGGTATAAAAACATTAGCGTCACTGACACGGCAAAATGGAGCAACCAAGGGGCAACATTTATCCGTCA
GCTGTACAACATGCTGCAACTCGCCCGTGTCATTACACTTGGCGCGTACAATCGCAATGAAAGCCGCGGAGCGCACTACA
AACCGGAGTTTCCGGAGCGCAATGACAAAGAGTGGCTGAAAACGACGATGGCTCGCTATACGCCAGACGGTCCGTCGTTC
CATTACGAAGACGTCGATGTTTCGTTGATTAAGCCGCGCAAACGCGACTACAGCAAAAAGAAAGAGGAAGTGAAGTAA

Upstream 100 bases:

>100_bases
CAGCCGTTCGTCGAACGACCGCTTGGTCGATGGGGCGAATCGGCGGAGCAAACCGTGGATATTGAAGCAAAAGCAGCAAT
TTTCTAGGGAGTGAGTAGCC

Downstream 100 bases:

>100_bases
GATGAGCGAGAACAAAACGGTTCGATTCATCATTACGCGCCAAGATCGTCCGGACTCTGCACCATATGAAGAAGAGTTTG
TCATCCCGTACCGTCCGAAC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MKKGKIIVVGGGLAGLMATIKIAEAGVPVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPGIIYMLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQILYALDEQVRRHEVAGLVTKYEHWEF
LGVVLDDEQICRGIVAQDLRSMEIKAFPADAVILATGGPGIIFGKSTNSVINTGSAASIAYQQGVYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIAAREIFHVCVDLKLGINGENMVYLDLSHKDPKE
LDVKLGGIIEIYEKFMGEDPRKVPMKVFPAVHYSMGGLWVDYDQMTNIKGLFAAGECDYSIHGANRLGANSLLSAIYGGM
VAGPNAVRYIRGLEKSADALPSTLFDSYVKQEQEKWENILSMDGTENAYVLHKELGEWMTANVTIVRYNDRLLKTDEKIQ
ELMERYKNISVTDTAKWSNQGATFIRQLYNMLQLARVITLGAYNRNESRGAHYKPEFPERNDKEWLKTTMARYTPDGPSF
HYEDVDVSLIKPRKRDYSKKKEEVK

Sequences:

>Translated_585_residues
MKKGKIIVVGGGLAGLMATIKIAEAGVPVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPGIIYMLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQILYALDEQVRRHEVAGLVTKYEHWEF
LGVVLDDEQICRGIVAQDLRSMEIKAFPADAVILATGGPGIIFGKSTNSVINTGSAASIAYQQGVYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIAAREIFHVCVDLKLGINGENMVYLDLSHKDPKE
LDVKLGGIIEIYEKFMGEDPRKVPMKVFPAVHYSMGGLWVDYDQMTNIKGLFAAGECDYSIHGANRLGANSLLSAIYGGM
VAGPNAVRYIRGLEKSADALPSTLFDSYVKQEQEKWENILSMDGTENAYVLHKELGEWMTANVTIVRYNDRLLKTDEKIQ
ELMERYKNISVTDTAKWSNQGATFIRQLYNMLQLARVITLGAYNRNESRGAHYKPEFPERNDKEWLKTTMARYTPDGPSF
HYEDVDVSLIKPRKRDYSKKKEEVK
>Mature_585_residues
MKKGKIIVVGGGLAGLMATIKIAEAGVPVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPGIIYMLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQILYALDEQVRRHEVAGLVTKYEHWEF
LGVVLDDEQICRGIVAQDLRSMEIKAFPADAVILATGGPGIIFGKSTNSVINTGSAASIAYQQGVYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIAAREIFHVCVDLKLGINGENMVYLDLSHKDPKE
LDVKLGGIIEIYEKFMGEDPRKVPMKVFPAVHYSMGGLWVDYDQMTNIKGLFAAGECDYSIHGANRLGANSLLSAIYGGM
VAGPNAVRYIRGLEKSADALPSTLFDSYVKQEQEKWENILSMDGTENAYVLHKELGEWMTANVTIVRYNDRLLKTDEKIQ
ELMERYKNISVTDTAKWSNQGATFIRQLYNMLQLARVITLGAYNRNESRGAHYKPEFPERNDKEWLKTTMARYTPDGPSF
HYEDVDVSLIKPRKRDYSKKKEEVK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=545, Percent_Identity=29.9082568807339, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1790597, Length=569, Percent_Identity=33.5676625659051, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1786942, Length=580, Percent_Identity=32.2413793103448, Blast_Score=243, Evalue=4e-65,
Organism=Escherichia coli, GI1788928, Length=552, Percent_Identity=29.1666666666667, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17505833, Length=546, Percent_Identity=31.1355311355311, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=541, Percent_Identity=30.1293900184843, Blast_Score=216, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6322701, Length=551, Percent_Identity=31.3974591651543, Blast_Score=230, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=30.5054151624549, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137288, Length=541, Percent_Identity=31.6081330868762, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24655642, Length=541, Percent_Identity=31.6081330868762, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24655647, Length=541, Percent_Identity=31.6081330868762, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24663005, Length=553, Percent_Identity=31.2839059674503, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65332; Mature: 65332

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGKIIVVGGGLAGLMATIKIAEAGVPVELFSLVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCCEEEEECCHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCHHHCCCCCCCCCCCCCCC
SPWEHFDDTVYGGDFLANQPPVKAMCEAAPGIIYMLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHCCCCEECCCCCCCCCCHHHHHHCCCCCEEEHHHCCCEECCCCHHHHHHHHCCCCC
HHRTAYAGATTGQQILYALDEQVRRHEVAGLVTKYEHWEFLGVVLDDEQICRGIVAQDLR
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHH
SMEIKAFPADAVILATGGPGIIFGKSTNSVINTGSAASIAYQQGVYYANGEFIQIHPTAI
HCEEEEECCCEEEEEECCCEEEEECCCCCEEECCCCCEEHHHCCEEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIAAREIFHVCVDLK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEE
LGINGENMVYLDLSHKDPKELDVKLGGIIEIYEKFMGEDPRKVPMKVFPAVHYSMGGLWV
ECCCCCCEEEEEECCCCCHHHHEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIKGLFAAGECDYSIHGANRLGANSLLSAIYGGMVAGPNAVRYIRGLEKSADAL
EHHHHCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
PSTLFDSYVKQEQEKWENILSMDGTENAYVLHKELGEWMTANVTIVRYNDRLLKTDEKIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCEECCEEEEEECCCHHCCHHHHH
ELMERYKNISVTDTAKWSNQGATFIRQLYNMLQLARVITLGAYNRNESRGAHYKPEFPER
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDKEWLKTTMARYTPDGPSFHYEDVDVSLIKPRKRDYSKKKEEVK
CCHHHHHHHHHHCCCCCCCEEECCCCEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKGKIIVVGGGLAGLMATIKIAEAGVPVELFSLVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCCEEEEECCHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCHHHCCCCCCCCCCCCCCC
SPWEHFDDTVYGGDFLANQPPVKAMCEAAPGIIYMLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHCCCCEECCCCCCCCCCHHHHHHCCCCCEEEHHHCCCEECCCCHHHHHHHHCCCCC
HHRTAYAGATTGQQILYALDEQVRRHEVAGLVTKYEHWEFLGVVLDDEQICRGIVAQDLR
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHH
SMEIKAFPADAVILATGGPGIIFGKSTNSVINTGSAASIAYQQGVYYANGEFIQIHPTAI
HCEEEEECCCEEEEEECCCEEEEECCCCCEEECCCCCEEHHHCCEEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIAAREIFHVCVDLK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEE
LGINGENMVYLDLSHKDPKELDVKLGGIIEIYEKFMGEDPRKVPMKVFPAVHYSMGGLWV
ECCCCCCEEEEEECCCCCHHHHEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIKGLFAAGECDYSIHGANRLGANSLLSAIYGGMVAGPNAVRYIRGLEKSADAL
EHHHHCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
PSTLFDSYVKQEQEKWENILSMDGTENAYVLHKELGEWMTANVTIVRYNDRLLKTDEKIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCEECCEEEEEECCCHHCCHHHHH
ELMERYKNISVTDTAKWSNQGATFIRQLYNMLQLARVITLGAYNRNESRGAHYKPEFPER
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDKEWLKTTMARYTPDGPSFHYEDVDVSLIKPRKRDYSKKKEEVK
CCHHHHHHHHHHCCCCCCCEEECCCCEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]