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The map label for this gene is accC [H]

Identifier: 138895969

GI number: 138895969

Start: 2451420

End: 2452775

Strand: Reverse

Name: accC [H]

Synonym: GTNG_2330

Alternate gene names: 138895969

Gene position: 2452775-2451420 (Counterclockwise)

Preceding gene: 138895970

Following gene: 138895968

Centisome position: 69.09

GC content: 53.02

Gene sequence:

>1356_bases
ATGATCAAAAAAGTGTTAGTGGCAAACCGCGGGGAAATCGCTGTCCGCATCATCCGCGCTTGCCGCGAGCTCGGCATTGA
GACGGTCGCCGTGTTTTCGGAAGCTGATCGCGACGCCCTGCATGTGCAGCTCGCGGATGAGGCGTACTGCATCGGACCGA
CCGCTTCAAAAGACAGTTATTTAAATTTCACGAACATCATGAGCGTCGCCACGCTAACCGGTTGTGACGCCATTCACCCG
GGTTACGGATTTTTGGCGGAGAATGAGGCATTTGCCGAGCTGTGCCGTGAGTGCAATGTTACGTTTATCGGTCCGAGTCC
GGAAGCGATTACAAAAATGGGCATTAAAGATATCGCTCGCGAGACGATGCGTGAAGCCGGCGTGCCGATCGTGCCCGGAT
CGCGCGGAGTGATTGAAAGCATTGATGAAGCGCGGGCCATCGCCGCAGAGATCGGCTACCCGGTCATCATTAAAGCGACG
GCCGGCGGCGGCGGAAAAGGGATTCGCGTCGCCCGCAACGAAGAGGAGCTCATCAAAGGGATTAACATCACTCAGCAAGA
AGCGGCAACTGCATTCGGCAATCCAGGCGTGTATATTGAAAAGTATATTGAAGATTTTCGCCATGTTGAGATTCAAGTGC
TGGCCGATTCGTACGGCAATACGATCCATCTCGGCGAGCGCGACTGCACGATTCAGCGCCGGCTGCAAAAGCTTGTTGAA
GAAGCTCCATCGCCAGCGCTCGATGATGAGATTCGCCAAAAAATGGGCGAAGCGGCGGTCAAGGCGGCAAAAGCGGTCAA
TTACACCGGCGCCGGCACGGTTGAATTTATTTTCGACCACCGGAACAACGAGTTTTATTTCATGGAGATGAATACGCGCA
TTCAAGTCGAGCATCCAGTCACCGAGTTGATCACTGGCGTCGATTTAGTGAAAGAGCAAATCCGCATCGCATCCGGTGAA
AAGCTGTCCCTCACCCAAGAGGACGTCGTCTTTAACGGTTGGGCGATTGAATGCCGCATCAACGCGGAAAATCCGGCGAA
AAACTTCATGCCGTCGCCGGGGAAAATCGCCATGTACTTGCCGCCAGGTGGGCCGGGTGTGCGCGTCGATTCCGCTGCTT
ATCCAGGTTATGCGATTCCGCCGTATTACGACTCGATGATCGCTAAATTGATCGTCCATGCACCGACGCGCGAGGAAGCG
ATCGCCCGCATGAGACGAGCGCTTGGCGAGTTTATCATCGAAGGCATTCATACGACGATTCCGTTCCACATAAAATTAAT
GGAGCATGAGAAATTTCAAAGCGGCGAGTTTAATACAAAGTTTTTGGAGTTATATGATATTATGAAGGCGGAATAG

Upstream 100 bases:

>100_bases
CGACGGCGAAATTGTCGAGGTGCTCGTGCAAAACGGCCAGCTCGTCGAATACGGCCAGCCGTTATTTTTGGTCAAGCCTG
AATAAGGGAGAGAACGGAGA

Downstream 100 bases:

>100_bases
GAGGTGCCTTATGTCTGAACATGTGTTTGAACCCAGTCAGGAGTATGCTGGGCTTGGCAAAGTGGAAATCGCACCGGAGG
TCATTGAAGTGATCGCCGGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MIKKVLVANRGEIAVRIIRACRELGIETVAVFSEADRDALHVQLADEAYCIGPTASKDSYLNFTNIMSVATLTGCDAIHP
GYGFLAENEAFAELCRECNVTFIGPSPEAITKMGIKDIARETMREAGVPIVPGSRGVIESIDEARAIAAEIGYPVIIKAT
AGGGGKGIRVARNEEELIKGINITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADSYGNTIHLGERDCTIQRRLQKLVE
EAPSPALDDEIRQKMGEAAVKAAKAVNYTGAGTVEFIFDHRNNEFYFMEMNTRIQVEHPVTELITGVDLVKEQIRIASGE
KLSLTQEDVVFNGWAIECRINAENPAKNFMPSPGKIAMYLPPGGPGVRVDSAAYPGYAIPPYYDSMIAKLIVHAPTREEA
IARMRRALGEFIIEGIHTTIPFHIKLMEHEKFQSGEFNTKFLELYDIMKAE

Sequences:

>Translated_451_residues
MIKKVLVANRGEIAVRIIRACRELGIETVAVFSEADRDALHVQLADEAYCIGPTASKDSYLNFTNIMSVATLTGCDAIHP
GYGFLAENEAFAELCRECNVTFIGPSPEAITKMGIKDIARETMREAGVPIVPGSRGVIESIDEARAIAAEIGYPVIIKAT
AGGGGKGIRVARNEEELIKGINITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADSYGNTIHLGERDCTIQRRLQKLVE
EAPSPALDDEIRQKMGEAAVKAAKAVNYTGAGTVEFIFDHRNNEFYFMEMNTRIQVEHPVTELITGVDLVKEQIRIASGE
KLSLTQEDVVFNGWAIECRINAENPAKNFMPSPGKIAMYLPPGGPGVRVDSAAYPGYAIPPYYDSMIAKLIVHAPTREEA
IARMRRALGEFIIEGIHTTIPFHIKLMEHEKFQSGEFNTKFLELYDIMKAE
>Mature_451_residues
MIKKVLVANRGEIAVRIIRACRELGIETVAVFSEADRDALHVQLADEAYCIGPTASKDSYLNFTNIMSVATLTGCDAIHP
GYGFLAENEAFAELCRECNVTFIGPSPEAITKMGIKDIARETMREAGVPIVPGSRGVIESIDEARAIAAEIGYPVIIKAT
AGGGGKGIRVARNEEELIKGINITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADSYGNTIHLGERDCTIQRRLQKLVE
EAPSPALDDEIRQKMGEAAVKAAKAVNYTGAGTVEFIFDHRNNEFYFMEMNTRIQVEHPVTELITGVDLVKEQIRIASGE
KLSLTQEDVVFNGWAIECRINAENPAKNFMPSPGKIAMYLPPGGPGVRVDSAAYPGYAIPPYYDSMIAKLIVHAPTREEA
IARMRRALGEFIIEGIHTTIPFHIKLMEHEKFQSGEFNTKFLELYDIMKAE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=50.6787330316742, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=51.7006802721088, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=51.7006802721088, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=51.7006802721088, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI106049528, Length=459, Percent_Identity=47.4945533769063, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=459, Percent_Identity=47.4945533769063, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=459, Percent_Identity=47.4945533769063, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI38679960, Length=503, Percent_Identity=31.610337972167, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI38679974, Length=503, Percent_Identity=31.610337972167, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI38679977, Length=503, Percent_Identity=31.610337972167, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI38679967, Length=503, Percent_Identity=31.610337972167, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI38679971, Length=503, Percent_Identity=31.610337972167, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=31.547619047619, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI18105007, Length=227, Percent_Identity=25.5506607929515, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=58.3333333333333, Blast_Score=490, Evalue=1e-140,
Organism=Escherichia coli, GI1786216, Length=363, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=47.6404494382022, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=49.3212669683258, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.9821428571429, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=31.4928425357873, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=29.7455968688845, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=29.7455968688845, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193204318, Length=237, Percent_Identity=25.7383966244726, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=43.3707865168539, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.1901565995526, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.8612975391499, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323863, Length=492, Percent_Identity=32.1138211382114, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.0077519379845, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322331, Length=327, Percent_Identity=24.1590214067278, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=47.8841870824053, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=49.2170022371365, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=46.9586374695864, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=30.5220883534137, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=30.5220883534137, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=30.5220883534137, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=30.5220883534137, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI45555749, Length=240, Percent_Identity=24.1666666666667, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24642586, Length=240, Percent_Identity=24.1666666666667, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49741; Mature: 49741

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLVANRGEIAVRIIRACRELGIETVAVFSEADRDALHVQLADEAYCIGPTASKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNFTNIMSVATLTGCDAIHPGYGFLAENEAFAELCRECNVTFIGPSPEAITKMGIKDIAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
ETMREAGVPIVPGSRGVIESIDEARAIAAEIGYPVIIKATAGGGGKGIRVARNEEELIKG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHC
INITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADSYGNTIHLGERDCTIQRRLQKLVE
CCCCHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSPALDDEIRQKMGEAAVKAAKAVNYTGAGTVEFIFDHRNNEFYFMEMNTRIQVEHPV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCEEEECCCH
TELITGVDLVKEQIRIASGEKLSLTQEDVVFNGWAIECRINAENPAKNFMPSPGKIAMYL
HHHHHHHHHHHHHHHHCCCCEEEEEHHCEEEECEEEEEEECCCCCHHHCCCCCCCEEEEE
PPGGPGVRVDSAAYPGYAIPPYYDSMIAKLIVHAPTREEAIARMRRALGEFIIEGIHTTI
CCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PFHIKLMEHEKFQSGEFNTKFLELYDIMKAE
CEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIKKVLVANRGEIAVRIIRACRELGIETVAVFSEADRDALHVQLADEAYCIGPTASKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNFTNIMSVATLTGCDAIHPGYGFLAENEAFAELCRECNVTFIGPSPEAITKMGIKDIAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
ETMREAGVPIVPGSRGVIESIDEARAIAAEIGYPVIIKATAGGGGKGIRVARNEEELIKG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHC
INITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADSYGNTIHLGERDCTIQRRLQKLVE
CCCCHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSPALDDEIRQKMGEAAVKAAKAVNYTGAGTVEFIFDHRNNEFYFMEMNTRIQVEHPV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCEEEECCCH
TELITGVDLVKEQIRIASGEKLSLTQEDVVFNGWAIECRINAENPAKNFMPSPGKIAMYL
HHHHHHHHHHHHHHHHCCCCEEEEEHHCEEEECEEEEEEECCCCCHHHCCCCCCCEEEEE
PPGGPGVRVDSAAYPGYAIPPYYDSMIAKLIVHAPTREEAIARMRRALGEFIIEGIHTTI
CCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PFHIKLMEHEKFQSGEFNTKFLELYDIMKAE
CEEEEEEECCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]