Click here to switch to the map view.

The map label for this gene is recQ [H]

Identifier: 138895822

GI number: 138895822

Start: 2305135

End: 2306658

Strand: Reverse

Name: recQ [H]

Synonym: GTNG_2181

Alternate gene names: 138895822

Gene position: 2306658-2305135 (Counterclockwise)

Preceding gene: 138895823

Following gene: 138895821

Centisome position: 64.97

GC content: 57.94

Gene sequence:

>1524_bases
TTGGATGAATTAATAAAAATCTTGCATGCGCAATTCGGACATGCCTCGTTCCGTCCGGGGCAGCGGGAAGTGGTTGAAGA
CGTGCTCGCCGGACGCGATGTGTTGGCGATGTTGCCGACTGGAAGCGGCAAGTCGCTTTGCTATCAGCTGCCGGCGTATT
TGCTCCCCGGAAGCGTGCTTGTTGTTTCGCCGCTTGTCTCGCTCATGGAAGACCAAGTCGAACAGCTGCGCCGGCGAGGG
GAAAAGCGGGTGATTGCTTTCCATAGCTTGCTCGATGCCGAAGAAAAATGGCAGGCGCTCGCCTCGCTGCCCGATTTTCG
CTTCATTTACGCTTCGCCGGAAATGCTGCAATCGGCAAAATTTTTGACGGCGCTTGGGCGTACGCGCATTTCCTTATTTG
TTGTCGATGAAGCGCATTGCATTTCTCAATGGGGCTATGATTTCCGCCCTGACTTTTTAAAACTAGGGACGGTCCGGCGC
GCGCTCGGTTCGCCGCCGTGCTTGGCGCTGACGGCGACGGCGCCGCCGGAAGTGCGGGATGATATCGTCCGTACGCTCGG
GATGGAGCGCGCCTGCCTCCATATTTATTCTGTCGACCGCCCCAACATCGCCTTAAAGGTTGAGTATTGCTTGTCGGCTG
AGGAAAAAGCAGCGCGTTTAGTTGAATATGCGAGGCAGCTTGAAGGGCCAGGGATCGTTTACTTTTCGAGCCGTCAATGG
GCGGAAGAAATGGCGCGCCGCCTTGAGCAGAGCGGAGCGGGGCGGGTGGCGTACTACCACGCCGGCATGGACGGAGAGCA
GCGGTTGCTCGTGCAGCAGCAATTTTTATACGGTCAGCTCGATATCGTTTGTTGCACGAGTGCGTTTGGCATGGGCGTGA
ACAAAGAAAACGTTCGGTTTGTGCTCCATTTTCATATGCCGGCCCAGCTCGAGGCGTACGTCCAGGAAATTGGGCGCGCC
GGGCGCGACGGGGCGCCGAGCTTGGCTGTGCTGTTTTACGCTGATGGCGATCGGGCCATCGCCCAAGCGGTGGCTGAAGC
CGAGCTTCCCGACCCGCACGAGCTGCGTGAATGGTGTTGGCGGCTCCCGGACAACGTTGCTGTGGAGCAATGGAATGCTG
CCATCGAAGCAAGCGGGTTTACGGAGATACAAAAACGGCTCTTGACGTACTTGTTAGAATGGGGACAAACAGCGCCGCCT
GGTCGGCTCACGGCAGAGGTGAAGGAGCAACTGTACGAAAGAATGGCCGCGGCGATTGAAACGCGGCGGCGCTGGAAGCG
AAAAAAGCTGCATGAAATGGACGACTGGGTGCACACATCTTCCTGCCGGCGCGCGATGATCGTTCGCGCGTTCGGGGAAG
AGCTAATGGACAAGCCGGGTGACTGCTGCGACTGTTGTGGGCTGCGGCTCGATGCCTATATGCGTGACACCCGTCGCTTG
GCTGCGGCGCCGATTCGCCATTGGCGTGAAGAGCTATGGCAAATGTTTTTCAGCAGGGGGCGGCAAGATGAGACGGCAAA
GTGA

Upstream 100 bases:

>100_bases
GGGCGCTCGGGACGCGCAAGTTAAAGCACATCCGCGAGGCGCTCGGCGGCGCAGTCAGTTATTTTGAAATTCGTCTCGTT
TTAGCAAAGGAAGTGGGACG

Downstream 100 bases:

>100_bases
ACAAATCCGACATATGACAGACCGCGAAGTGCTTTTTCATCTTTATTTGACGCAAGCGTTGTTGCTTATCGTTGCCGGCG
TCGTCTCATTCTTTTTGTTC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MDELIKILHAQFGHASFRPGQREVVEDVLAGRDVLAMLPTGSGKSLCYQLPAYLLPGSVLVVSPLVSLMEDQVEQLRRRG
EKRVIAFHSLLDAEEKWQALASLPDFRFIYASPEMLQSAKFLTALGRTRISLFVVDEAHCISQWGYDFRPDFLKLGTVRR
ALGSPPCLALTATAPPEVRDDIVRTLGMERACLHIYSVDRPNIALKVEYCLSAEEKAARLVEYARQLEGPGIVYFSSRQW
AEEMARRLEQSGAGRVAYYHAGMDGEQRLLVQQQFLYGQLDIVCCTSAFGMGVNKENVRFVLHFHMPAQLEAYVQEIGRA
GRDGAPSLAVLFYADGDRAIAQAVAEAELPDPHELREWCWRLPDNVAVEQWNAAIEASGFTEIQKRLLTYLLEWGQTAPP
GRLTAEVKEQLYERMAAAIETRRRWKRKKLHEMDDWVHTSSCRRAMIVRAFGEELMDKPGDCCDCCGLRLDAYMRDTRRL
AAAPIRHWREELWQMFFSRGRQDETAK

Sequences:

>Translated_507_residues
MDELIKILHAQFGHASFRPGQREVVEDVLAGRDVLAMLPTGSGKSLCYQLPAYLLPGSVLVVSPLVSLMEDQVEQLRRRG
EKRVIAFHSLLDAEEKWQALASLPDFRFIYASPEMLQSAKFLTALGRTRISLFVVDEAHCISQWGYDFRPDFLKLGTVRR
ALGSPPCLALTATAPPEVRDDIVRTLGMERACLHIYSVDRPNIALKVEYCLSAEEKAARLVEYARQLEGPGIVYFSSRQW
AEEMARRLEQSGAGRVAYYHAGMDGEQRLLVQQQFLYGQLDIVCCTSAFGMGVNKENVRFVLHFHMPAQLEAYVQEIGRA
GRDGAPSLAVLFYADGDRAIAQAVAEAELPDPHELREWCWRLPDNVAVEQWNAAIEASGFTEIQKRLLTYLLEWGQTAPP
GRLTAEVKEQLYERMAAAIETRRRWKRKKLHEMDDWVHTSSCRRAMIVRAFGEELMDKPGDCCDCCGLRLDAYMRDTRRL
AAAPIRHWREELWQMFFSRGRQDETAK
>Mature_507_residues
MDELIKILHAQFGHASFRPGQREVVEDVLAGRDVLAMLPTGSGKSLCYQLPAYLLPGSVLVVSPLVSLMEDQVEQLRRRG
EKRVIAFHSLLDAEEKWQALASLPDFRFIYASPEMLQSAKFLTALGRTRISLFVVDEAHCISQWGYDFRPDFLKLGTVRR
ALGSPPCLALTATAPPEVRDDIVRTLGMERACLHIYSVDRPNIALKVEYCLSAEEKAARLVEYARQLEGPGIVYFSSRQW
AEEMARRLEQSGAGRVAYYHAGMDGEQRLLVQQQFLYGQLDIVCCTSAFGMGVNKENVRFVLHFHMPAQLEAYVQEIGRA
GRDGAPSLAVLFYADGDRAIAQAVAEAELPDPHELREWCWRLPDNVAVEQWNAAIEASGFTEIQKRLLTYLLEWGQTAPP
GRLTAEVKEQLYERMAAAIETRRRWKRKKLHEMDDWVHTSSCRRAMIVRAFGEELMDKPGDCCDCCGLRLDAYMRDTRRL
AAAPIRHWREELWQMFFSRGRQDETAK

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242943, Length=352, Percent_Identity=40.625, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI51242947, Length=352, Percent_Identity=40.625, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI148612816, Length=353, Percent_Identity=40.5099150141643, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557365, Length=368, Percent_Identity=37.7717391304348, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI110735439, Length=344, Percent_Identity=38.953488372093, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI169218196, Length=344, Percent_Identity=38.953488372093, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI14591902, Length=343, Percent_Identity=35.8600583090379, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI14591904, Length=343, Percent_Identity=35.8600583090379, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI284005309, Length=345, Percent_Identity=37.3913043478261, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI41327771, Length=385, Percent_Identity=23.6363636363636, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI262118318, Length=413, Percent_Identity=23.2445520581114, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI216548263, Length=413, Percent_Identity=23.728813559322, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI148613856, Length=332, Percent_Identity=26.8072289156627, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38201710, Length=332, Percent_Identity=26.8072289156627, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI262231852, Length=413, Percent_Identity=23.2445520581114, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI13518015, Length=413, Percent_Identity=23.728813559322, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI188035877, Length=351, Percent_Identity=21.3675213675214, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI4758112, Length=376, Percent_Identity=25.2659574468085, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI18375623, Length=376, Percent_Identity=25.2659574468085, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994977, Length=341, Percent_Identity=46.3343108504399, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI87082221, Length=369, Percent_Identity=25.4742547425474, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI32564293, Length=345, Percent_Identity=40.2898550724638, Blast_Score=251, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI25145561, Length=348, Percent_Identity=39.6551724137931, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71987997, Length=343, Percent_Identity=39.6501457725948, Blast_Score=238, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71987993, Length=343, Percent_Identity=39.6501457725948, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17552866, Length=370, Percent_Identity=34.8648648648649, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI115533224, Length=361, Percent_Identity=26.0387811634349, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32565321, Length=370, Percent_Identity=23.2432432432432, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508543, Length=380, Percent_Identity=21.8421052631579, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17510309, Length=383, Percent_Identity=24.0208877284595, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510307, Length=383, Percent_Identity=24.0208877284595, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71995514, Length=383, Percent_Identity=23.7597911227154, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982858, Length=336, Percent_Identity=24.702380952381, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=349, Percent_Identity=38.6819484240688, Blast_Score=243, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6324217, Length=357, Percent_Identity=26.0504201680672, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320449, Length=372, Percent_Identity=23.3870967741935, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321360, Length=361, Percent_Identity=23.8227146814404, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321963, Length=350, Percent_Identity=25.1428571428571, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321267, Length=377, Percent_Identity=23.8726790450928, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646066, Length=382, Percent_Identity=36.9109947643979, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24664226, Length=359, Percent_Identity=37.0473537604457, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI62472181, Length=357, Percent_Identity=36.6946778711485, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24664230, Length=357, Percent_Identity=36.6946778711485, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21358123, Length=364, Percent_Identity=37.3626373626374, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24584994, Length=381, Percent_Identity=24.4094488188976, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28575014, Length=355, Percent_Identity=23.6619718309859, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24666101, Length=362, Percent_Identity=24.8618784530387, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644479, Length=342, Percent_Identity=24.8538011695906, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644487, Length=343, Percent_Identity=24.7813411078717, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551833, Length=343, Percent_Identity=24.7813411078717, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644485, Length=343, Percent_Identity=24.7813411078717, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281361218, Length=342, Percent_Identity=24.8538011695906, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644481, Length=342, Percent_Identity=24.8538011695906, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644483, Length=342, Percent_Identity=24.8538011695906, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574962, Length=329, Percent_Identity=23.7082066869301, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 57673; Mature: 57673

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELIKILHAQFGHASFRPGQREVVEDVLAGRDVLAMLPTGSGKSLCYQLPAYLLPGSVL
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHH
VVSPLVSLMEDQVEQLRRRGEKRVIAFHSLLDAEEKWQALASLPDFRFIYASPEMLQSAK
HHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHCHHHHHHHHHCCCCCEEEECCHHHHHHHH
FLTALGRTRISLFVVDEAHCISQWGYDFRPDFLKLGTVRRALGSPPCLALTATAPPEVRD
HHHHHCCCEEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
DIVRTLGMERACLHIYSVDRPNIALKVEYCLSAEEKAARLVEYARQLEGPGIVYFSSRQW
HHHHHHCCHHHHHEEEECCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCCCEEEECCHHH
AEEMARRLEQSGAGRVAYYHAGMDGEQRLLVQQQFLYGQLDIVCCTSAFGMGVNKENVRF
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHEEEHHHHCCCCCCCCEEE
VLHFHMPAQLEAYVQEIGRAGRDGAPSLAVLFYADGDRAIAQAVAEAELPDPHELREWCW
EEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHH
RLPDNVAVEQWNAAIEASGFTEIQKRLLTYLLEWGQTAPPGRLTAEVKEQLYERMAAAIE
CCCCCCHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
TRRRWKRKKLHEMDDWVHTSSCRRAMIVRAFGEELMDKPGDCCDCCGLRLDAYMRDTRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHH
AAAPIRHWREELWQMFFSRGRQDETAK
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDELIKILHAQFGHASFRPGQREVVEDVLAGRDVLAMLPTGSGKSLCYQLPAYLLPGSVL
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHH
VVSPLVSLMEDQVEQLRRRGEKRVIAFHSLLDAEEKWQALASLPDFRFIYASPEMLQSAK
HHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHCHHHHHHHHHCCCCCEEEECCHHHHHHHH
FLTALGRTRISLFVVDEAHCISQWGYDFRPDFLKLGTVRRALGSPPCLALTATAPPEVRD
HHHHHCCCEEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
DIVRTLGMERACLHIYSVDRPNIALKVEYCLSAEEKAARLVEYARQLEGPGIVYFSSRQW
HHHHHHCCHHHHHEEEECCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCCCEEEECCHHH
AEEMARRLEQSGAGRVAYYHAGMDGEQRLLVQQQFLYGQLDIVCCTSAFGMGVNKENVRF
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHEEEHHHHCCCCCCCCEEE
VLHFHMPAQLEAYVQEIGRAGRDGAPSLAVLFYADGDRAIAQAVAEAELPDPHELREWCW
EEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHH
RLPDNVAVEQWNAAIEASGFTEIQKRLLTYLLEWGQTAPPGRLTAEVKEQLYERMAAAIE
CCCCCCHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
TRRRWKRKKLHEMDDWVHTSSCRRAMIVRAFGEELMDKPGDCCDCCGLRLDAYMRDTRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHH
AAAPIRHWREELWQMFFSRGRQDETAK
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]