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The map label for this gene is trpE [H]

Identifier: 138895782

GI number: 138895782

Start: 2269067

End: 2270593

Strand: Reverse

Name: trpE [H]

Synonym: GTNG_2138

Alternate gene names: 138895782

Gene position: 2270593-2269067 (Counterclockwise)

Preceding gene: 138895783

Following gene: 138895781

Centisome position: 63.95

GC content: 51.41

Gene sequence:

>1527_bases
ATGTCCACGAATGGGCTAGCCGCTTTTTTAGCGGATGCCAACGAGTTCCGCACTATCCCGATTGTGCGCAAATTTTTAGC
CGATGTCATTGAACCGCTTGGAGTATTTAGCAATTTGCGTGATGAAGCGGTGTTTTTGCTCGAAAGCAAAGACGATGAAT
CACCATGGGCTCGCTATTCGTTTATCGGGGTCGCGCCGTTTTTGACACTCGAAAGCGAAACAGGCGAGACGTTTTCCGTG
AAAGACGAAAATGGAAACGAACAAGTTGTAATGCCGACGTTGAAAGAGGCGTTTCAATGGGCTGAGCAGGCGCTTGATGT
CCGACCGTTGAGAGAAGTAGTGCCGTTTACAGGCGGCGCGGTCGGGTTTTTAGGATACGATTTCATTTCAGCCATCGAAA
AGGTGCCGCGTCATGAAAATTGTGATTTAGGTATGAAAGCTAGTTATTTCGTATTTTGCGAATCGCTGTTTGCTTTTGAC
CACCAAAAGCGTGAGCTCCTGCTTATTCACTATATTCGGTTGCATGGTGGTGAAACAGAACAGGAAAAGATTGAGAAATA
TCGCTCCGCCCAACAGCGCATCGCCGCGTTGGCGGCAAAAGCGGTGCGAATCCAAGCTGAACGGCCGCTGTTGCCGGCAG
ATGAGGAAGCCGGGCGGGCTGTCTCGTTTGCTCAGGCGATGTCCAATTACGAAAAAGAACGATTTTTGCAAGACGTAGAA
ACGGTGAAACAGTATATCGCGGCTGGTGATGTGTTTCAAGCTGTTCTGTCGCAGCGTTTTTGCGTGCCGGTCCGCGCGGG
CGGTTTGGCCGTTTATCGGTTGCTCCGCCATATTAATCCGTCGCCGTACATGTTTTATTTCCGGTTGAGTGATACAGAAA
TTGTTGGAAGTTCACCGGAAAAACTCATCCAAGTGCGCAATCGGCGCATTGAAATCGATCCGATCGCCGGAACGAGGCGG
CGCGGGCGCTCGCCCGAAGAGGATGCGATGCTGGCTGATGAGCTGTACAACGATCCGAAGGAGCGGGCTGAGCATTATAT
GCTCGTTGATTTGGCACGCAACGATATCGGCCGGGTGGCAAAATACGGAACGGTCAAGACGCCAATCTTGATGGAAATCG
GCAAGTTTTCCCACGTGATGCATTTAATTTCGAAAGTCGTCGGTGAGTTGAATGATGATGTTCACCCCATTGATGCGTTG
CTTGCCGCCTTTCCGGCTGGGACGGTGAGCGGAGCGCCGAAAGTGCGGGCGATGCAAATTTTACAAGAGCTTGAGCCAAC
AGCTCGCGGATTGTACGCCGGGGCGATTGCTTACATCGGCTTTGACGGCAATATCGACTCATGCATTGCCATCCGGACGG
CGGTCATCAAAGATGGCTATGCGTACGTGCAGGCCGGCGCGGGCATCGTCGCTGACTCCGTCCCAGAACTTGAGTGGAAA
GAGACGTGCAATAAAGCAAGCGCCTTAATGAACGCCATTGAACAAGCAGAACGACTATTTGTCAAAGGGGAGAGGATCGT
ATGTTGA

Upstream 100 bases:

>100_bases
GACATCTGCCCAAAGACGGTCGTCTTTGGGCGTTTTCTTTCCTCTTTTCGCCTCATAAACCCTCATTCTCCGCCCGCTGA
TCATGAAGGGAGGAGAAGGG

Downstream 100 bases:

>100_bases
AGCGGCTGCTTTCCAAATGTGCGGAAGGGAAAACGTTGACGGAAGAAGAAGCATATGAAGCGATGGCCACCGTCATGGAT
GGGGCGGCGACAGACAGCCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSTNGLAAFLADANEFRTIPIVRKFLADVIEPLGVFSNLRDEAVFLLESKDDESPWARYSFIGVAPFLTLESETGETFSV
KDENGNEQVVMPTLKEAFQWAEQALDVRPLREVVPFTGGAVGFLGYDFISAIEKVPRHENCDLGMKASYFVFCESLFAFD
HQKRELLLIHYIRLHGGETEQEKIEKYRSAQQRIAALAAKAVRIQAERPLLPADEEAGRAVSFAQAMSNYEKERFLQDVE
TVKQYIAAGDVFQAVLSQRFCVPVRAGGLAVYRLLRHINPSPYMFYFRLSDTEIVGSSPEKLIQVRNRRIEIDPIAGTRR
RGRSPEEDAMLADELYNDPKERAEHYMLVDLARNDIGRVAKYGTVKTPILMEIGKFSHVMHLISKVVGELNDDVHPIDAL
LAAFPAGTVSGAPKVRAMQILQELEPTARGLYAGAIAYIGFDGNIDSCIAIRTAVIKDGYAYVQAGAGIVADSVPELEWK
ETCNKASALMNAIEQAERLFVKGERIVC

Sequences:

>Translated_508_residues
MSTNGLAAFLADANEFRTIPIVRKFLADVIEPLGVFSNLRDEAVFLLESKDDESPWARYSFIGVAPFLTLESETGETFSV
KDENGNEQVVMPTLKEAFQWAEQALDVRPLREVVPFTGGAVGFLGYDFISAIEKVPRHENCDLGMKASYFVFCESLFAFD
HQKRELLLIHYIRLHGGETEQEKIEKYRSAQQRIAALAAKAVRIQAERPLLPADEEAGRAVSFAQAMSNYEKERFLQDVE
TVKQYIAAGDVFQAVLSQRFCVPVRAGGLAVYRLLRHINPSPYMFYFRLSDTEIVGSSPEKLIQVRNRRIEIDPIAGTRR
RGRSPEEDAMLADELYNDPKERAEHYMLVDLARNDIGRVAKYGTVKTPILMEIGKFSHVMHLISKVVGELNDDVHPIDAL
LAAFPAGTVSGAPKVRAMQILQELEPTARGLYAGAIAYIGFDGNIDSCIAIRTAVIKDGYAYVQAGAGIVADSVPELEWK
ETCNKASALMNAIEQAERLFVKGERIVC
>Mature_507_residues
STNGLAAFLADANEFRTIPIVRKFLADVIEPLGVFSNLRDEAVFLLESKDDESPWARYSFIGVAPFLTLESETGETFSVK
DENGNEQVVMPTLKEAFQWAEQALDVRPLREVVPFTGGAVGFLGYDFISAIEKVPRHENCDLGMKASYFVFCESLFAFDH
QKRELLLIHYIRLHGGETEQEKIEKYRSAQQRIAALAAKAVRIQAERPLLPADEEAGRAVSFAQAMSNYEKERFLQDVET
VKQYIAAGDVFQAVLSQRFCVPVRAGGLAVYRLLRHINPSPYMFYFRLSDTEIVGSSPEKLIQVRNRRIEIDPIAGTRRR
GRSPEEDAMLADELYNDPKERAEHYMLVDLARNDIGRVAKYGTVKTPILMEIGKFSHVMHLISKVVGELNDDVHPIDALL
AAFPAGTVSGAPKVRAMQILQELEPTARGLYAGAIAYIGFDGNIDSCIAIRTAVIKDGYAYVQAGAGIVADSVPELEWKE
TCNKASALMNAIEQAERLFVKGERIVC

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=412, Percent_Identity=37.378640776699, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788114, Length=455, Percent_Identity=32.967032967033, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1786809, Length=267, Percent_Identity=29.9625468164794, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082077, Length=272, Percent_Identity=29.0441176470588, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320935, Length=476, Percent_Identity=39.9159663865546, Blast_Score=302, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=23.8213399503722, Blast_Score=98, Evalue=4e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56637; Mature: 56506

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNGLAAFLADANEFRTIPIVRKFLADVIEPLGVFSNLRDEAVFLLESKDDESPWARYS
CCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHEE
FIGVAPFLTLESETGETFSVKDENGNEQVVMPTLKEAFQWAEQALDVRPLREVVPFTGGA
HEEECEEEEEECCCCCEEEEECCCCCCEEECHHHHHHHHHHHHHCCHHHHHHHCCCCCCH
VGFLGYDFISAIEKVPRHENCDLGMKASYFVFCESLFAFDHQKRELLLIHYIRLHGGETE
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCH
QEKIEKYRSAQQRIAALAAKAVRIQAERPLLPADEEAGRAVSFAQAMSNYEKERFLQDVE
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TVKQYIAAGDVFQAVLSQRFCVPVRAGGLAVYRLLRHINPSPYMFYFRLSDTEIVGSSPE
HHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCEEEEEEECCCEECCCCHH
KLIQVRNRRIEIDPIAGTRRRGRSPEEDAMLADELYNDPKERAEHYMLVDLARNDIGRVA
HHHHHHCCEEEECCCCCCHHCCCCCCHHHHHHHHHHCCHHHHHHHEEEEHHHHHHHHHHH
KYGTVKTPILMEIGKFSHVMHLISKVVGELNDDVHPIDALLAAFPAGTVSGAPKVRAMQI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHH
LQELEPTARGLYAGAIAYIGFDGNIDSCIAIRTAVIKDGYAYVQAGAGIVADSVPELEWK
HHHHCHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHCCCCCCCHHH
ETCNKASALMNAIEQAERLFVKGERIVC
HHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STNGLAAFLADANEFRTIPIVRKFLADVIEPLGVFSNLRDEAVFLLESKDDESPWARYS
CCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHEE
FIGVAPFLTLESETGETFSVKDENGNEQVVMPTLKEAFQWAEQALDVRPLREVVPFTGGA
HEEECEEEEEECCCCCEEEEECCCCCCEEECHHHHHHHHHHHHHCCHHHHHHHCCCCCCH
VGFLGYDFISAIEKVPRHENCDLGMKASYFVFCESLFAFDHQKRELLLIHYIRLHGGETE
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCH
QEKIEKYRSAQQRIAALAAKAVRIQAERPLLPADEEAGRAVSFAQAMSNYEKERFLQDVE
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TVKQYIAAGDVFQAVLSQRFCVPVRAGGLAVYRLLRHINPSPYMFYFRLSDTEIVGSSPE
HHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCEEEEEEECCCEECCCCHH
KLIQVRNRRIEIDPIAGTRRRGRSPEEDAMLADELYNDPKERAEHYMLVDLARNDIGRVA
HHHHHHCCEEEECCCCCCHHCCCCCCHHHHHHHHHHCCHHHHHHHEEEEHHHHHHHHHHH
KYGTVKTPILMEIGKFSHVMHLISKVVGELNDDVHPIDALLAAFPAGTVSGAPKVRAMQI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHH
LQELEPTARGLYAGAIAYIGFDGNIDSCIAIRTAVIKDGYAYVQAGAGIVADSVPELEWK
HHHHCHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHCCCCCCCHHH
ETCNKASALMNAIEQAERLFVKGERIVC
HHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840498 [H]