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The map label for this gene is paaX [H]

Identifier: 138895547

GI number: 138895547

Start: 2023398

End: 2024273

Strand: Reverse

Name: paaX [H]

Synonym: GTNG_1897

Alternate gene names: 138895547

Gene position: 2024273-2023398 (Counterclockwise)

Preceding gene: 138895548

Following gene: 138895546

Centisome position: 57.02

GC content: 45.32

Gene sequence:

>876_bases
ATGAAGCCAAGGGCACTTATGTTTACGCTATTTGGAGAATATATTCAACATTATGGGAATGAAGTTTGGATTGGAAGTTT
GATCCAGATGATGTCCCACTTCGGCATTTCCGAGTCGTCCATTCGTGGGGCGGCGCTCAGGATGGTGCAACAAGAATTTT
TTGAGGTGCGGAAAATCGGCAATAACAGCTATTACTCACTGACGCCAAAAGGGAAGCGGACAATGATGGATGGATTCACA
CGCGTCTATTCGTTGCGAAACTACAAATGGGATGGCCGTTGGCGCGTGTTAACGTATTCCGTTCCAGAAGAAAAACGGGA
GCTGCGCAGCCAAATCCGCAAAGAATTAAGTTTGATGGGGTTTGGTCTTATTTCTCACGGGACATGGGCGAGCCCGAATC
CGATTGAACCACAAGTCATGGAATGGATAAAAGATTATCATTTAGAGCCATATGTCATTTTGTTTACGGCGGACTCCATC
GTGTCACACAGCAACGAACAAATCATCGAACGCGGTTGGGATTTTGCTTATATCGCCAAAGAGTATGACAAATTTATTGA
AACGTACGAACGAAAGTATGAGGAGTTTCAAAAGCAAGCTTGGAACAATGAATTGACCGATCGCGAATGTTTTATTGAGC
GAACAAAACTCGTACATGAATACCGGAGCTTTTTCTTTATTGACCCGGGGTTTCCACATGACTTATTGCCCGATGATTGG
AGCGGGACGAGAGCTCGGGAGTTGTTTTTCAATGTCCATCAGCTGCTTGCTATTCCCGCCATTCGTTACTTTGAAACGTT
GTTTGAGCCTGCTCCGGACCGTGAGTCGGTGTTCAATCGCGATAGGGCGATCAACCCGTTTATGGAGATAATTTAG

Upstream 100 bases:

>100_bases
CGATATATTTTTGTGTAAAAACAATTATTCTCGATTGAAAAAGAGTGGGAAAATGTAACATAATAAAAGAAAAATCTGAA
AAAAGACAGGTGTTGTCGTA

Downstream 100 bases:

>100_bases
AGCGCTGGTGGAAAGCGTGATTTCTTGATAGTGGTCGTTTTGGCGAACTCTAAACAATCAAGATTTATATACTAGAGAAA
TGTCTTTTTGTACTCTCACT

Product: repressor -like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKPRALMFTLFGEYIQHYGNEVWIGSLIQMMSHFGISESSIRGAALRMVQQEFFEVRKIGNNSYYSLTPKGKRTMMDGFT
RVYSLRNYKWDGRWRVLTYSVPEEKRELRSQIRKELSLMGFGLISHGTWASPNPIEPQVMEWIKDYHLEPYVILFTADSI
VSHSNEQIIERGWDFAYIAKEYDKFIETYERKYEEFQKQAWNNELTDRECFIERTKLVHEYRSFFFIDPGFPHDLLPDDW
SGTRARELFFNVHQLLAIPAIRYFETLFEPAPDRESVFNRDRAINPFMEII

Sequences:

>Translated_291_residues
MKPRALMFTLFGEYIQHYGNEVWIGSLIQMMSHFGISESSIRGAALRMVQQEFFEVRKIGNNSYYSLTPKGKRTMMDGFT
RVYSLRNYKWDGRWRVLTYSVPEEKRELRSQIRKELSLMGFGLISHGTWASPNPIEPQVMEWIKDYHLEPYVILFTADSI
VSHSNEQIIERGWDFAYIAKEYDKFIETYERKYEEFQKQAWNNELTDRECFIERTKLVHEYRSFFFIDPGFPHDLLPDDW
SGTRARELFFNVHQLLAIPAIRYFETLFEPAPDRESVFNRDRAINPFMEII
>Mature_291_residues
MKPRALMFTLFGEYIQHYGNEVWIGSLIQMMSHFGISESSIRGAALRMVQQEFFEVRKIGNNSYYSLTPKGKRTMMDGFT
RVYSLRNYKWDGRWRVLTYSVPEEKRELRSQIRKELSLMGFGLISHGTWASPNPIEPQVMEWIKDYHLEPYVILFTADSI
VSHSNEQIIERGWDFAYIAKEYDKFIETYERKYEEFQKQAWNNELTDRECFIERTKLVHEYRSFFFIDPGFPHDLLPDDW
SGTRARELFFNVHQLLAIPAIRYFETLFEPAPDRESVFNRDRAINPFMEII

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=262, Percent_Identity=30.1526717557252, Blast_Score=131, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 34788; Mature: 34788

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRALMFTLFGEYIQHYGNEVWIGSLIQMMSHFGISESSIRGAALRMVQQEFFEVRKIG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
NNSYYSLTPKGKRTMMDGFTRVYSLRNYKWDGRWRVLTYSVPEEKRELRSQIRKELSLMG
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
FGLISHGTWASPNPIEPQVMEWIKDYHLEPYVILFTADSIVSHSNEQIIERGWDFAYIAK
HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHCCHHHHHHCCCCHHHHHH
EYDKFIETYERKYEEFQKQAWNNELTDRECFIERTKLVHEYRSFFFIDPGFPHDLLPDDW
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCC
SGTRARELFFNVHQLLAIPAIRYFETLFEPAPDRESVFNRDRAINPFMEII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHC
>Mature Secondary Structure
MKPRALMFTLFGEYIQHYGNEVWIGSLIQMMSHFGISESSIRGAALRMVQQEFFEVRKIG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
NNSYYSLTPKGKRTMMDGFTRVYSLRNYKWDGRWRVLTYSVPEEKRELRSQIRKELSLMG
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
FGLISHGTWASPNPIEPQVMEWIKDYHLEPYVILFTADSIVSHSNEQIIERGWDFAYIAK
HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHCCHHHHHHCCCCHHHHHH
EYDKFIETYERKYEEFQKQAWNNELTDRECFIERTKLVHEYRSFFFIDPGFPHDLLPDDW
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCC
SGTRARELFFNVHQLLAIPAIRYFETLFEPAPDRESVFNRDRAINPFMEII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]