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The map label for this gene is sqhC [H]

Identifier: 138895534

GI number: 138895534

Start: 2009009

End: 2010862

Strand: Reverse

Name: sqhC [H]

Synonym: GTNG_1884

Alternate gene names: 138895534

Gene position: 2010862-2009009 (Counterclockwise)

Preceding gene: 138895538

Following gene: 138895533

Centisome position: 56.64

GC content: 55.07

Gene sequence:

>1854_bases
GTGGCCGGTGAACGAAGTGCGTTGATTACCGCGCTCAAACGGTCGCAAGCGGCTGACGGATCGTGGCGATTTCCGTTTGA
AACAGGCATTTCGACAGACGCTTATATGATCATTTTATTGCGGACGCTTGACATAAATGATGAACCGTTGATTCAGGCGC
TCGTCGAGCGGATTGAGAGCCGGCAGGAGGCAAATGGGGCATGGAAGCTGTTTGCGGATGAAGGTGACGGCAACGTAACC
GCCACAGTGGAAGCGTACTATGCGCTGCTTTACTCCGGCTATCGCCAGCCAACCGATCGGCATATGCAAAAAGCGAAAAG
GCGAATTTTAGACATGGGTGGCCTCGACCGCGTCCACTTGTTTACAAAGGTTATGCTCGCGTTGACCGGGCAGTACCCGT
GGCCAGGCCGTTTCCCGCTGCCGCTTGAATTTTTCTTGCTTCCGCCGTCATTTCCACTCAATATGTATGATCTATCTGTC
TACGGAAGAGCGAATATGATCCCGCTTTTGATCGCGGCCGACAGCCGCTACAGCCGGAAAACGGACAAAAGTCCGGATCT
TTCTGATTTGTTTGCCTCCCGCGGTGATTGGGGGATGCCGGAAAGCCGATCGCTGCTAACGTACGTCAAGCGGTCGCTCA
TCGGGCTTCCAGCCCAGCTTCATCAAGCTGCCAAACAGCGTGCGGTTCGTTATCTGTTCGAGCATATCGAACCGGACGGA
ACGCTGTATAGCTATTTCAGTTCAACTTTTTTATTCATTTTTGCGCTGCTTGCGCTCGGCTATCGGAACGACGATCCGCG
CATTAGGCAGGCTGTCCGCGGGTTGCGCTCATTGCGTACAACGATCGATGGACATGTGCATCTGCAATATACGACTGCTT
CGGTTTGGAATACGGCGTTAGCGAGCTATACGTTGCAAGAAGCAGGCGTGCCGATGACCGACCGGGCGATCGAAAAGGCG
AACCGTTATTTGTTGTCACGCCAGAACGTCCGCTACGGCGACTGGGCGGTGCATAACCCGTACAGCACACCAGGCGGCTG
GGGGTTTTCCGATGTCAATACAATGAATCCAGATGTCGACGATACGACCGCCGCATTGCGTGCCATCCGTCAGGCGGCAG
CGAAAGAGACGGCGTTTCGCCATGCGTGGGACCGAGCTAACCAATGGCTGTTTTCGATGCAAAATGATGACGGGGGCTTT
GCGGCGTTTGAAAAAAACGTGAGCTCCCGCTTTTGGCGCTATTTGCCGATCGAAGGGGCGGAGTTTTTGCTGATGGATCC
GTCAACAGCCGACCTAACCGGGCGGACGCTCGAATATTTCGGGACATTTGCTGGCTTAACGAAAGACCAGCGCGCCGTCT
CTCGCGCTGTCGACTGGCTGCTGAGCCATCAAGAAAGAAACGGCTCGTGGTACGGCCGCTGGGGAATTTGCTATATATAT
GGAACATGGGCGGCCATCACCGGGCTTACAGCCGTTGGCGTCCCGGCTCACCATCCCGCCCTGCAAAAAGCTGTCCGCTG
GTTGTTAAGCATCCAAAACGATGACGGCGGCTGGGGAGAATCGTGCAAAAGCGACGGAGCGAAAACGTACGTGCCGCTTG
GCGACAGCACACCAGTTCATACCGCTTGGGCGCTTGATGCCTTAGTCGCCGCTGCCGAGCGTCCAACCCTGGAAATGAAA
GCCGGCTTTCGCGCCTTATTTCGTTTGCTTCATCATCCGGACTGGACGGCTTCCTATCCGGTCGGGCAAGGAATGGCCGG
CGCCTTTTACATCCACTACCATAGCTATCGTTACATTTTCCCGCTGTTAGCGCTGGCTCATTACGAGCAAAAGTTCGGGC
CGCTTGACGATTAA

Upstream 100 bases:

>100_bases
AGGCAGCGCATAGCGATCCCCCTTTCAGTGCATCGACGGCCCGCCAGACGAATAAATATGGAAGGAAACGGAGTTTCGTG
AAAAAGGAAGGCGATGCACG

Downstream 100 bases:

>100_bases
CCGTGCACCTGCCGTTTGTCTTTTTGGCTACATTAACAAAAAAGCAACAGAGGCAAACGACGGCATGGCGAAAATCAAGC
GGCACTTGATTACCGGTACC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MAGERSALITALKRSQAADGSWRFPFETGISTDAYMIILLRTLDINDEPLIQALVERIESRQEANGAWKLFADEGDGNVT
ATVEAYYALLYSGYRQPTDRHMQKAKRRILDMGGLDRVHLFTKVMLALTGQYPWPGRFPLPLEFFLLPPSFPLNMYDLSV
YGRANMIPLLIAADSRYSRKTDKSPDLSDLFASRGDWGMPESRSLLTYVKRSLIGLPAQLHQAAKQRAVRYLFEHIEPDG
TLYSYFSSTFLFIFALLALGYRNDDPRIRQAVRGLRSLRTTIDGHVHLQYTTASVWNTALASYTLQEAGVPMTDRAIEKA
NRYLLSRQNVRYGDWAVHNPYSTPGGWGFSDVNTMNPDVDDTTAALRAIRQAAAKETAFRHAWDRANQWLFSMQNDDGGF
AAFEKNVSSRFWRYLPIEGAEFLLMDPSTADLTGRTLEYFGTFAGLTKDQRAVSRAVDWLLSHQERNGSWYGRWGICYIY
GTWAAITGLTAVGVPAHHPALQKAVRWLLSIQNDDGGWGESCKSDGAKTYVPLGDSTPVHTAWALDALVAAAERPTLEMK
AGFRALFRLLHHPDWTASYPVGQGMAGAFYIHYHSYRYIFPLLALAHYEQKFGPLDD

Sequences:

>Translated_617_residues
MAGERSALITALKRSQAADGSWRFPFETGISTDAYMIILLRTLDINDEPLIQALVERIESRQEANGAWKLFADEGDGNVT
ATVEAYYALLYSGYRQPTDRHMQKAKRRILDMGGLDRVHLFTKVMLALTGQYPWPGRFPLPLEFFLLPPSFPLNMYDLSV
YGRANMIPLLIAADSRYSRKTDKSPDLSDLFASRGDWGMPESRSLLTYVKRSLIGLPAQLHQAAKQRAVRYLFEHIEPDG
TLYSYFSSTFLFIFALLALGYRNDDPRIRQAVRGLRSLRTTIDGHVHLQYTTASVWNTALASYTLQEAGVPMTDRAIEKA
NRYLLSRQNVRYGDWAVHNPYSTPGGWGFSDVNTMNPDVDDTTAALRAIRQAAAKETAFRHAWDRANQWLFSMQNDDGGF
AAFEKNVSSRFWRYLPIEGAEFLLMDPSTADLTGRTLEYFGTFAGLTKDQRAVSRAVDWLLSHQERNGSWYGRWGICYIY
GTWAAITGLTAVGVPAHHPALQKAVRWLLSIQNDDGGWGESCKSDGAKTYVPLGDSTPVHTAWALDALVAAAERPTLEMK
AGFRALFRLLHHPDWTASYPVGQGMAGAFYIHYHSYRYIFPLLALAHYEQKFGPLDD
>Mature_616_residues
AGERSALITALKRSQAADGSWRFPFETGISTDAYMIILLRTLDINDEPLIQALVERIESRQEANGAWKLFADEGDGNVTA
TVEAYYALLYSGYRQPTDRHMQKAKRRILDMGGLDRVHLFTKVMLALTGQYPWPGRFPLPLEFFLLPPSFPLNMYDLSVY
GRANMIPLLIAADSRYSRKTDKSPDLSDLFASRGDWGMPESRSLLTYVKRSLIGLPAQLHQAAKQRAVRYLFEHIEPDGT
LYSYFSSTFLFIFALLALGYRNDDPRIRQAVRGLRSLRTTIDGHVHLQYTTASVWNTALASYTLQEAGVPMTDRAIEKAN
RYLLSRQNVRYGDWAVHNPYSTPGGWGFSDVNTMNPDVDDTTAALRAIRQAAAKETAFRHAWDRANQWLFSMQNDDGGFA
AFEKNVSSRFWRYLPIEGAEFLLMDPSTADLTGRTLEYFGTFAGLTKDQRAVSRAVDWLLSHQERNGSWYGRWGICYIYG
TWAAITGLTAVGVPAHHPALQKAVRWLLSIQNDDGGWGESCKSDGAKTYVPLGDSTPVHTAWALDALVAAAERPTLEMKA
GFRALFRLLHHPDWTASYPVGQGMAGAFYIHYHSYRYIFPLLALAHYEQKFGPLDD

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=647, Percent_Identity=26.4296754250386, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI47933395, Length=647, Percent_Identity=26.2751159196291, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI47933397, Length=647, Percent_Identity=26.2751159196291, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI224177556, Length=585, Percent_Identity=26.4957264957265, Blast_Score=133, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321863, Length=630, Percent_Identity=24.6031746031746, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 69555; Mature: 69424

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGERSALITALKRSQAADGSWRFPFETGISTDAYMIILLRTLDINDEPLIQALVERIES
CCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHH
RQEANGAWKLFADEGDGNVTATVEAYYALLYSGYRQPTDRHMQKAKRRILDMGGLDRVHL
HHCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHH
FTKVMLALTGQYPWPGRFPLPLEFFLLPPSFPLNMYDLSVYGRANMIPLLIAADSRYSRK
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCCCC
TDKSPDLSDLFASRGDWGMPESRSLLTYVKRSLIGLPAQLHQAAKQRAVRYLFEHIEPDG
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
TLYSYFSSTFLFIFALLALGYRNDDPRIRQAVRGLRSLRTTIDGHVHLQYTTASVWNTAL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHH
ASYTLQEAGVPMTDRAIEKANRYLLSRQNVRYGDWAVHNPYSTPGGWGFSDVNTMNPDVD
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
DTTAALRAIRQAAAKETAFRHAWDRANQWLFSMQNDDGGFAAFEKNVSSRFWRYLPIEGA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHEEEECCCCC
EFLLMDPSTADLTGRTLEYFGTFAGLTKDQRAVSRAVDWLLSHQERNGSWYGRWGICYIY
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCEEEEEE
GTWAAITGLTAVGVPAHHPALQKAVRWLLSIQNDDGGWGESCKSDGAKTYVPLGDSTPVH
EHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCCCCCHHHCCCCEEEEECCCCCCCH
TAWALDALVAAAERPTLEMKAGFRALFRLLHHPDWTASYPVGQGMAGAFYIHYHSYRYIF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHHH
PLLALAHYEQKFGPLDD
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AGERSALITALKRSQAADGSWRFPFETGISTDAYMIILLRTLDINDEPLIQALVERIES
CCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHH
RQEANGAWKLFADEGDGNVTATVEAYYALLYSGYRQPTDRHMQKAKRRILDMGGLDRVHL
HHCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHH
FTKVMLALTGQYPWPGRFPLPLEFFLLPPSFPLNMYDLSVYGRANMIPLLIAADSRYSRK
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCCCC
TDKSPDLSDLFASRGDWGMPESRSLLTYVKRSLIGLPAQLHQAAKQRAVRYLFEHIEPDG
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
TLYSYFSSTFLFIFALLALGYRNDDPRIRQAVRGLRSLRTTIDGHVHLQYTTASVWNTAL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHH
ASYTLQEAGVPMTDRAIEKANRYLLSRQNVRYGDWAVHNPYSTPGGWGFSDVNTMNPDVD
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
DTTAALRAIRQAAAKETAFRHAWDRANQWLFSMQNDDGGFAAFEKNVSSRFWRYLPIEGA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHEEEECCCCC
EFLLMDPSTADLTGRTLEYFGTFAGLTKDQRAVSRAVDWLLSHQERNGSWYGRWGICYIY
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCEEEEEE
GTWAAITGLTAVGVPAHHPALQKAVRWLLSIQNDDGGWGESCKSDGAKTYVPLGDSTPVH
EHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCCCCCHHHCCCCEEEEECCCCCCCH
TAWALDALVAAAERPTLEMKAGFRALFRLLHHPDWTASYPVGQGMAGAFYIHYHSYRYIF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHHH
PLLALAHYEQKFGPLDD
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]