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The map label for this gene is mtlD

Identifier: 138895496

GI number: 138895496

Start: 1965721

End: 1966878

Strand: Reverse

Name: mtlD

Synonym: GTNG_1844

Alternate gene names: 138895496

Gene position: 1966878-1965721 (Counterclockwise)

Preceding gene: 138895497

Following gene: 138895495

Centisome position: 55.4

GC content: 54.58

Gene sequence:

>1158_bases
ATGAGGGCCGTTCACTTCGGCGCAGGCAATATTGGCCGCGGTTTTATCGGCAGCCTGCTTGCAGCGTCGGGATATGATGT
CGTGTTTGTCGATGTCAACGAACAAATTGTCCGCCTGCTGAAGGAGCGGGGAGAGTATCGCGTTATTATTGCCGGCGAGC
GGCAGGAAGAACAATGGGTGCGCGGTGTTTCCGCACTCAACAGTCAAACCGAACGGGACGATGTCATTGAGGCGATCGCG
TCCGCTGATTTGGTGACGACTGCGGTCGGCCCGCACATTTTGCCGGTCATTGCGCCCGTCATCGCCGCCGGATTGGAGCG
ACGATTCACAGTTCATCAGAAGCCGCTTCACGTCATTGCATGCGAAAATATGATCGGCGGCACGGAAACGCTGAAACAGC
ATGTCGTTACCCATCTTTCCGAAGCCGGACGGCAGCTGGTGGAAGAATGTGTCGGGTTCCTTAACTGCGCGGTCGACCGC
ATCGTGCCGAATCAGACGAATGACGATCCACTCGCTGTCACGGTTGAGCCGTTTTTCGAATGGGCGATTGAGACGAAAAA
CACTATCGGCGCCGTTCCCCCGATTCAAGGGGCACATTTTGTCGCTGACCTAGGACCGTATATCGAGCGCAAATTGTTTA
CAGTTAATACCGGCCATGCGTTGGCTGCCTATTTAGGTTATCAAAAACAATACCGAACGGTTCAGGAAGCGATGAAGGAT
AGCGGCATCCGGGAGAGTGTCGAGCAGGCGCTCCGCGAGTCAGGAGCCGTCTTAGTGAAAAAGCACGGCTGGGATGAACA
AGAGCACCGTTCGTATATTGAAACGACGATCGGACGTTTCACCAATCCGTCCCTTTCCGATGACATCGTCCGCGTCGCCC
GTTCACCAATCCGCAAGCTCGGGCCGAACGATCGGCTTGTCGCACCGGCTGTGCAATATTACACTTTATTCGAACGTGTG
CCGTCCGGACTTGTCAAAGGCATTGCTGCGCTGCTGTTGTTTGATGAGACCGGCGATGCCGAAGCAACTGCTCTCCAGCA
AACGATCGAACAGAGCGGTGTCGAAGGAGCGCTCGTCCAATATGCAGGGCTTGACAATAGCCATCCGCTCGTCGTGGCGG
TGAAGGAAGAATATAAGAAGATGCAAAAAGAGCAATAA

Upstream 100 bases:

>100_bases
AACTCGCGCTCGTCTGCGCGGAAGCGGACAATGTTGCGGCTATGGCGAACGCCAAAACAGCGGAGGAAATTCTTACGCTG
CTTAATGAGGTGAACGGCTG

Downstream 100 bases:

>100_bases
AGATAAGGGGTTCGTCTCGTTTTACCGCTAGCCTTCACGGCTGGCGGCATTTTTTTTGTGAATATGAACATGCCGATTAT
CGTCTTTTCCGTTACAATGC

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIIAGERQEEQWVRGVSALNSQTERDDVIEAIA
SADLVTTAVGPHILPVIAPVIAAGLERRFTVHQKPLHVIACENMIGGTETLKQHVVTHLSEAGRQLVEECVGFLNCAVDR
IVPNQTNDDPLAVTVEPFFEWAIETKNTIGAVPPIQGAHFVADLGPYIERKLFTVNTGHALAAYLGYQKQYRTVQEAMKD
SGIRESVEQALRESGAVLVKKHGWDEQEHRSYIETTIGRFTNPSLSDDIVRVARSPIRKLGPNDRLVAPAVQYYTLFERV
PSGLVKGIAALLLFDETGDAEATALQQTIEQSGVEGALVQYAGLDNSHPLVVAVKEEYKKMQKEQ

Sequences:

>Translated_385_residues
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIIAGERQEEQWVRGVSALNSQTERDDVIEAIA
SADLVTTAVGPHILPVIAPVIAAGLERRFTVHQKPLHVIACENMIGGTETLKQHVVTHLSEAGRQLVEECVGFLNCAVDR
IVPNQTNDDPLAVTVEPFFEWAIETKNTIGAVPPIQGAHFVADLGPYIERKLFTVNTGHALAAYLGYQKQYRTVQEAMKD
SGIRESVEQALRESGAVLVKKHGWDEQEHRSYIETTIGRFTNPSLSDDIVRVARSPIRKLGPNDRLVAPAVQYYTLFERV
PSGLVKGIAALLLFDETGDAEATALQQTIEQSGVEGALVQYAGLDNSHPLVVAVKEEYKKMQKEQ
>Mature_385_residues
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIIAGERQEEQWVRGVSALNSQTERDDVIEAIA
SADLVTTAVGPHILPVIAPVIAAGLERRFTVHQKPLHVIACENMIGGTETLKQHVVTHLSEAGRQLVEECVGFLNCAVDR
IVPNQTNDDPLAVTVEPFFEWAIETKNTIGAVPPIQGAHFVADLGPYIERKLFTVNTGHALAAYLGYQKQYRTVQEAMKD
SGIRESVEQALRESGAVLVKKHGWDEQEHRSYIETTIGRFTNPSLSDDIVRVARSPIRKLGPNDRLVAPAVQYYTLFERV
PSGLVKGIAALLLFDETGDAEATALQQTIEQSGVEGALVQYAGLDNSHPLVVAVKEEYKKMQKEQ

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=386, Percent_Identity=46.3730569948187, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1787823, Length=228, Percent_Identity=31.5789473684211, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788497, Length=271, Percent_Identity=26.9372693726937, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790779, Length=214, Percent_Identity=31.3084112149533, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=240, Percent_Identity=27.9166666666667, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320765, Length=240, Percent_Identity=27.9166666666667, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_GEOTN (A4IPF0)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125949.1
- ProteinModelPortal:   A4IPF0
- STRING:   A4IPF0
- GeneID:   4966777
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1844
- NMPDR:   fig|420246.5.peg.1775
- eggNOG:   COG0246
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- PhylomeDB:   A4IPF0
- ProtClustDB:   PRK02318
- BioCyc:   GTHE420246:GTNG_1844-MONOMER
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 42314; Mature: 42314

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIIAGERQEEQWV
CCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCEEEEEECCCHHHHHH
RGVSALNSQTERDDVIEAIASADLVTTAVGPHILPVIAPVIAAGLERRFTVHQKPLHVIA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
CENMIGGTETLKQHVVTHLSEAGRQLVEECVGFLNCAVDRIVPNQTNDDPLAVTVEPFFE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHH
WAIETKNTIGAVPPIQGAHFVADLGPYIERKLFTVNTGHALAAYLGYQKQYRTVQEAMKD
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
SGIRESVEQALRESGAVLVKKHGWDEQEHRSYIETTIGRFTNPSLSDDIVRVARSPIRKL
CCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
GPNDRLVAPAVQYYTLFERVPSGLVKGIAALLLFDETGDAEATALQQTIEQSGVEGALVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHE
YAGLDNSHPLVVAVKEEYKKMQKEQ
EECCCCCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIIAGERQEEQWV
CCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCEEEEEECCCHHHHHH
RGVSALNSQTERDDVIEAIASADLVTTAVGPHILPVIAPVIAAGLERRFTVHQKPLHVIA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
CENMIGGTETLKQHVVTHLSEAGRQLVEECVGFLNCAVDRIVPNQTNDDPLAVTVEPFFE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHH
WAIETKNTIGAVPPIQGAHFVADLGPYIERKLFTVNTGHALAAYLGYQKQYRTVQEAMKD
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
SGIRESVEQALRESGAVLVKKHGWDEQEHRSYIETTIGRFTNPSLSDDIVRVARSPIRKL
CCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
GPNDRLVAPAVQYYTLFERVPSGLVKGIAALLLFDETGDAEATALQQTIEQSGVEGALVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHE
YAGLDNSHPLVVAVKEEYKKMQKEQ
EECCCCCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA