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The map label for this gene is gabT [C]

Identifier: 138895480

GI number: 138895480

Start: 1945676

End: 1947019

Strand: Reverse

Name: gabT [C]

Synonym: GTNG_1828

Alternate gene names: 138895480

Gene position: 1947019-1945676 (Counterclockwise)

Preceding gene: 138895484

Following gene: 138895479

Centisome position: 54.84

GC content: 47.47

Gene sequence:

>1344_bases
ATGTACATGAAACAGGGCAACTGGATGCCTCTCTTTCACAAAATGCATGATTTGCTTGCGCCAACGATGGCGAAAGATCA
TCCGAACTTGCCGGTGATCAAGGAAGAAGGTTGCTACTATTACGGATTGGATGGAAAAAAATATCTTGATTTTACTTCTG
GTATTGCTGTGGCCAATACGGGTCATCGTCATCCAAAGGTGGTGCAGGCCATCAAAGAGGCGGCAGACCGCCTAATGCAT
GGTCCAAGCGGCGTCATCATGTATGAGTCGATTCTCCGCTTGGCCGAGGAGCTTGCCGACATTATGCCTGAAGGGCTTGA
TTGCTTCTTTTTTGCGAATAGCGGAACGGAGGCAATTGAAGGAGCTATAAAACTAGCCAAGCATGTGACGCGAAGGCCGT
ATGTCATTTCCTTTACAGGGTGTTTTCATGGACGATCATTAGGAGCGCTTAGCGTCAGTACATCGAAAAGTAAATACCGG
AAATACTTGCAGCCCAACGGCTTGACGTATCAACTTCCATATGCCAATCCAAAACATTGTCCAGCAGGAGAGGATCTGGA
CGTGTACTTCACCCGTAAGCTTGAACGTGATGTGGCGTCTTTATTTGCCCATCAAGTGACGCCGGAAGAAGTGGCATGCA
TGATTGTCGAGCCGGTATTGGGAGAAGGGGGATATATCGTTCCTCCGAAAGGATGGCTACGCAAAATGAGGGAAATTTGC
GACCGCCATGGTATTTTGCTTATTTTTGATGAGGTGCAGACAGGATTTGGACGTACAGGGGAATGGTTTGCCGCTCAAAC
ATTTGGCGTCACTCCGGACATTATGGCCATTGCGAAGGGGATCGCTTCTGGACTGCCGCTAAGTGCAACAGTGGCTTCGA
AAGAATTGATGAAACAATGGCCGCTCGGCAGCCATGGGACAACTTTTGGCGGCAACCCCATTGCATGTGAGGCGGCGTTG
GCAACGTTAGAAGTATTTCGAGAAGAAAAGTTGTTGGAACGTTGTAGGGAAATGGGGGAATACGCACGAAAAAAGCTGGA
CGTGTTAAAAAGGAACCATCCAGTCATTGGAGACGTGCGTTCGATTGGACTCATGATCGGCATCGAAATCGTCCATCCGC
ACACCCTCGAACCAAATGGAGAAGGAGTCATGAATATTTTAAACCGTTGTCTGCAAAAAGGAGTTCTCTTTTATCTATGC
GGTAATCAAGGTGAAGTGATTCGTATGATCCCGCCGCTGATCGTGACAAAAGAACAGATTGACGAAGGATTAAGCATGTT
GGATGAAGCGTTGACAGAATATGAAGCAGAAATCGGTGTACATTCATTCGTGTCTGGGAAATGA

Upstream 100 bases:

>100_bases
AAATACACATCCCCCCCAACCACCGCTTTTCATGCTTAGATGGGGGAGCAATACTTTGTTCATGTGGGGTTCTATGAATC
AATCATTTGATTGAAGGAGG

Downstream 100 bases:

>100_bases
AAGAGATTTTTGGGGGGCGTGTCATCTATGACTTAAAGGTAAAAAGCGATAGAACTACTTGGACTGACGGATTCAAGGAT
GGATATCACACCTCACTCAA

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MYMKQGNWMPLFHKMHDLLAPTMAKDHPNLPVIKEEGCYYYGLDGKKYLDFTSGIAVANTGHRHPKVVQAIKEAADRLMH
GPSGVIMYESILRLAEELADIMPEGLDCFFFANSGTEAIEGAIKLAKHVTRRPYVISFTGCFHGRSLGALSVSTSKSKYR
KYLQPNGLTYQLPYANPKHCPAGEDLDVYFTRKLERDVASLFAHQVTPEEVACMIVEPVLGEGGYIVPPKGWLRKMREIC
DRHGILLIFDEVQTGFGRTGEWFAAQTFGVTPDIMAIAKGIASGLPLSATVASKELMKQWPLGSHGTTFGGNPIACEAAL
ATLEVFREEKLLERCREMGEYARKKLDVLKRNHPVIGDVRSIGLMIGIEIVHPHTLEPNGEGVMNILNRCLQKGVLFYLC
GNQGEVIRMIPPLIVTKEQIDEGLSMLDEALTEYEAEIGVHSFVSGK

Sequences:

>Translated_447_residues
MYMKQGNWMPLFHKMHDLLAPTMAKDHPNLPVIKEEGCYYYGLDGKKYLDFTSGIAVANTGHRHPKVVQAIKEAADRLMH
GPSGVIMYESILRLAEELADIMPEGLDCFFFANSGTEAIEGAIKLAKHVTRRPYVISFTGCFHGRSLGALSVSTSKSKYR
KYLQPNGLTYQLPYANPKHCPAGEDLDVYFTRKLERDVASLFAHQVTPEEVACMIVEPVLGEGGYIVPPKGWLRKMREIC
DRHGILLIFDEVQTGFGRTGEWFAAQTFGVTPDIMAIAKGIASGLPLSATVASKELMKQWPLGSHGTTFGGNPIACEAAL
ATLEVFREEKLLERCREMGEYARKKLDVLKRNHPVIGDVRSIGLMIGIEIVHPHTLEPNGEGVMNILNRCLQKGVLFYLC
GNQGEVIRMIPPLIVTKEQIDEGLSMLDEALTEYEAEIGVHSFVSGK
>Mature_447_residues
MYMKQGNWMPLFHKMHDLLAPTMAKDHPNLPVIKEEGCYYYGLDGKKYLDFTSGIAVANTGHRHPKVVQAIKEAADRLMH
GPSGVIMYESILRLAEELADIMPEGLDCFFFANSGTEAIEGAIKLAKHVTRRPYVISFTGCFHGRSLGALSVSTSKSKYR
KYLQPNGLTYQLPYANPKHCPAGEDLDVYFTRKLERDVASLFAHQVTPEEVACMIVEPVLGEGGYIVPPKGWLRKMREIC
DRHGILLIFDEVQTGFGRTGEWFAAQTFGVTPDIMAIAKGIASGLPLSATVASKELMKQWPLGSHGTTFGGNPIACEAAL
ATLEVFREEKLLERCREMGEYARKKLDVLKRNHPVIGDVRSIGLMIGIEIVHPHTLEPNGEGVMNILNRCLQKGVLFYLC
GNQGEVIRMIPPLIVTKEQIDEGLSMLDEALTEYEAEIGVHSFVSGK

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=426, Percent_Identity=33.5680751173709, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4557809, Length=426, Percent_Identity=32.8638497652582, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=29.1169451073986, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=28.9655172413793, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=27.816091954023, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI226442709, Length=404, Percent_Identity=29.4554455445545, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=32.9305135951662, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI188536080, Length=439, Percent_Identity=23.0068337129841, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38679950, Length=439, Percent_Identity=23.0068337129841, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38679946, Length=439, Percent_Identity=23.0068337129841, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1789016, Length=405, Percent_Identity=36.7901234567901, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1787560, Length=394, Percent_Identity=38.0710659898477, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788044, Length=413, Percent_Identity=33.1719128329298, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI145693181, Length=387, Percent_Identity=37.2093023255814, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=34.8039215686275, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786991, Length=428, Percent_Identity=30.1401869158879, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786349, Length=309, Percent_Identity=34.3042071197411, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=448, Percent_Identity=33.0357142857143, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI25144271, Length=422, Percent_Identity=31.7535545023697, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71992977, Length=412, Percent_Identity=31.7961165048544, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=30.7692307692308, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=437, Percent_Identity=24.9427917620137, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=147, Percent_Identity=31.9727891156463, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=31.2796208530806, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=30.5418719211823, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324386, Length=426, Percent_Identity=23.943661971831, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=357, Percent_Identity=25.2100840336134, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161085790, Length=421, Percent_Identity=33.9667458432304, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI28574759, Length=423, Percent_Identity=33.5697399527187, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=32.2274881516588, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=31.4903846153846, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI281366494, Length=374, Percent_Identity=25.668449197861, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667139, Length=374, Percent_Identity=25.668449197861, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667143, Length=374, Percent_Identity=25.668449197861, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 49596; Mature: 49596

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMKQGNWMPLFHKMHDLLAPTMAKDHPNLPVIKEEGCYYYGLDGKKYLDFTSGIAVANT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCEEEECCCCEEEECC
GHRHPKVVQAIKEAADRLMHGPSGVIMYESILRLAEELADIMPEGLDCFFFANSGTEAIE
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
GAIKLAKHVTRRPYVISFTGCFHGRSLGALSVSTSKSKYRKYLQPNGLTYQLPYANPKHC
HHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHCCCCCCEEECCCCCCCCC
PAGEDLDVYFTRKLERDVASLFAHQVTPEEVACMIVEPVLGEGGYIVPPKGWLRKMREIC
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
DRHGILLIFDEVQTGFGRTGEWFAAQTFGVTPDIMAIAKGIASGLPLSATVASKELMKQW
HHCCEEEEEECHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
PLGSHGTTFGGNPIACEAALATLEVFREEKLLERCREMGEYARKKLDVLKRNHPVIGDVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
SIGLMIGIEIVHPHTLEPNGEGVMNILNRCLQKGVLFYLCGNQGEVIRMIPPLIVTKEQI
HHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEECCCHHEEHHHH
DEGLSMLDEALTEYEAEIGVHSFVSGK
HHHHHHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MYMKQGNWMPLFHKMHDLLAPTMAKDHPNLPVIKEEGCYYYGLDGKKYLDFTSGIAVANT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCEEEECCCCEEEECC
GHRHPKVVQAIKEAADRLMHGPSGVIMYESILRLAEELADIMPEGLDCFFFANSGTEAIE
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
GAIKLAKHVTRRPYVISFTGCFHGRSLGALSVSTSKSKYRKYLQPNGLTYQLPYANPKHC
HHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHCCCCCCEEECCCCCCCCC
PAGEDLDVYFTRKLERDVASLFAHQVTPEEVACMIVEPVLGEGGYIVPPKGWLRKMREIC
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
DRHGILLIFDEVQTGFGRTGEWFAAQTFGVTPDIMAIAKGIASGLPLSATVASKELMKQW
HHCCEEEEEECHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
PLGSHGTTFGGNPIACEAALATLEVFREEKLLERCREMGEYARKKLDVLKRNHPVIGDVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
SIGLMIGIEIVHPHTLEPNGEGVMNILNRCLQKGVLFYLCGNQGEVIRMIPPLIVTKEQI
HHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEECCCHHEEHHHH
DEGLSMLDEALTEYEAEIGVHSFVSGK
HHHHHHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA