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The map label for this gene is infB [H]

Identifier: 138894783

GI number: 138894783

Start: 1179600

End: 1181807

Strand: Direct

Name: infB [H]

Synonym: GTNG_1117

Alternate gene names: 138894783

Gene position: 1179600-1181807 (Clockwise)

Preceding gene: 138894782

Following gene: 138894784

Centisome position: 33.23

GC content: 51.31

Gene sequence:

>2208_bases
ATGTCGAAAATGCGTGTGTACGAATACGCCAAAAAACATAATGTGCCAAGCAAGGACGTTATTCATAAATTGAAAGAAAT
GAATATTGAAGTGAACAACCATATGACTATGCTCGAAGCCGATGTCGTCGAAAAGCTCGATCATCAATACCGCGTGAACT
CAGAGAAAAAAGCGGAAAAGAAAACGGAGAAACCGAAGCGGCCGACGCCGGCGAAAGCCGCCGATTTTGCCGACGAGGAA
ATGTTTGAGGACAAGAAAGAAACGGCAAAGGCGAAGCCGGCGAAGAAAAAGGGAGCAGTGAAAGGAAAGGAAACGAAAAA
AACAGAAGCACAGCAGCAAGAAAAGAAACTGTTCCAAGCGGCGAAGAAAAAAGGAAAAGGACCGATGAAAGGCAAAAAAC
AAGCTGCCCCAGCCTCAAAGCAGGCGCAGCAGCCGGCGAAAAAAGAAAAAGAGCTCCCGAAAAAAATTACGTTCGAAGGT
TCGCTCACGGTAGCCGAATTGGCGAAAAAACTTGGCCGCGAGCCGTCGGAAATCATTAAAAAACTGTTTATGCTCGGCGT
CATGGCGACGATTAACCAAGATTTAGACAAAGATGCGATTGAGCTCATTTGCTCTGATTACGGAGTTGAAGTCGAAGAAA
AAGTGACGATCGATGAAACGAATTTTGAAACGATCGAAATTGTCGATGCGCCGGAAGATCTGGTGGAACGGCCGCCGGTC
GTCACGATTATGGGGCACGTTGACCACGGGAAAACAACGCTGCTTGACGCAATCCGCCACTCGAAAGTGACCGAGCAAGA
GGCGGGCGGTATTACACAGCATATCGGTGCTTATCAAGTCACGGTCAACGGCAAGAAAATTACGTTCCTCGATACGCCGG
GGCATGAAGCGTTTACGACGATGCGGGCGCGCGGTGCGCAAGTGACGGATATCGTCATCCTTGTTGTTGCTGCTGATGAT
GGGGTCATGCCGCAGACGGTCGAGGCGATTAACCACGCCAAAGCAGCGAACGTACCGATTATCGTCGCCATTAACAAAAT
GGATAAGCCGGAAGCAAACCCGGATCGCGTTATGCAAGAGTTGATGGAGTACAACCTCGTTCCGGAAGAATGGGGTGGCG
ATACGATTTTCTGCAAGCTGTCGGCGAAAACCCAAGACGGTATTGACCATCTGTTGGAAATGATTTTGCTTGTCAGCGAA
ATGGAAGAACTAAAAGCGAACCCGAACCGCCGCGCGCTCGGTACGGTGATCGAAGCGAAGCTCGATAAAGGGCGCGGTCC
GGTAGCGACGTTGCTCGTCCAAGCCGGTACGCTAAAAGTCGGTGATCCGATTGTTGTCGGCACAACGTACGGACGCGTGC
GCGCGATGGTCAATGACAGCGGTCGGCGTGTCAAAGAAGCGGGTCCGTCGATGCCGGTCGAAATCACAGGGCTTCATGAT
GTGCCGCAAGCCGGGGACCGCTTTATGGTATTTGAAGATGAGAAGAAAGCGCGACAAATCGGAGAAGCGCGGGCACAGCG
GCAGCTGCAAGAGCAGCGGAGCGTGAAAACGCGCGTCAGCTTGGACGATTTGTTTGAACAAATTAAGCAAGGTGAAATGA
AAGAGCTGAACTTGATCGTTAAGGCCGACGTCCAAGGATCGGTCGAAGCGCTTGTCGCCGCCTTGCAAAAAATCGATATC
GAAGGCGTGCGTGTGAAAATTATCCACGCGGCGGTCGGCGCCATTACGGAGTCAGACATCTTGTTGGCAACGACCTCGAA
CGCGATCGTCATCGGTTTTAACGTCCGTCCGGACACCAATGCGAAGCGGGCTGCCGAATCAGAAAACGTCGACATCCGCC
TCCACCGCATTATTTACAATGTCATCGAAGAAATTGAAGCGGCGATGAAAGGGATGCTCGACCCAGAATATGAAGAAAAA
GTGATCGGTCAGGCGGAAGTGCGGCAAACGTTCAAAGTGTCGAAAGTCGGCACGATCGCCGGGTGCTACGTCACCGACGG
CAAAATTACCCGCGACAGCAAAGTGCGCCTTATCCGTCAAGGCATCGTCGTGTACGAAGGCGAAATCGACTCGCTCAAAC
GGTATAAAGATGATGTGCGTGAGGTGGCGCAAGGATACGAATGCGGCGTGACTATCAAAAACTTCAACGATATTAAAGAA
GGGGACGTCATCGAGGCGTACATCATGCAGGAAGTGGCTCGCGCATGA

Upstream 100 bases:

>100_bases
GCGATCGGCAAAGACGCCCGCGTCGTTGTCGCCGTCACCGACGAAGGGTTCGCGCGCCAATTGCAAACGATGCTCGACTG
ATCTTTATGGGGGTGAATGT

Downstream 100 bases:

>100_bases
TCGGCTTCGCCTCATGCGAATGCATCATCTACAACGCCCAGTCGCTAAAAGACAAACGGGCTGTCCTTCAACGGGTGATG
ACAAGAATCCGGCAAAAATA

Product: translation initiation factor IF-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MSKMRVYEYAKKHNVPSKDVIHKLKEMNIEVNNHMTMLEADVVEKLDHQYRVNSEKKAEKKTEKPKRPTPAKAADFADEE
MFEDKKETAKAKPAKKKGAVKGKETKKTEAQQQEKKLFQAAKKKGKGPMKGKKQAAPASKQAQQPAKKEKELPKKITFEG
SLTVAELAKKLGREPSEIIKKLFMLGVMATINQDLDKDAIELICSDYGVEVEEKVTIDETNFETIEIVDAPEDLVERPPV
VTIMGHVDHGKTTLLDAIRHSKVTEQEAGGITQHIGAYQVTVNGKKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADD
GVMPQTVEAINHAKAANVPIIVAINKMDKPEANPDRVMQELMEYNLVPEEWGGDTIFCKLSAKTQDGIDHLLEMILLVSE
MEELKANPNRRALGTVIEAKLDKGRGPVATLLVQAGTLKVGDPIVVGTTYGRVRAMVNDSGRRVKEAGPSMPVEITGLHD
VPQAGDRFMVFEDEKKARQIGEARAQRQLQEQRSVKTRVSLDDLFEQIKQGEMKELNLIVKADVQGSVEALVAALQKIDI
EGVRVKIIHAAVGAITESDILLATTSNAIVIGFNVRPDTNAKRAAESENVDIRLHRIIYNVIEEIEAAMKGMLDPEYEEK
VIGQAEVRQTFKVSKVGTIAGCYVTDGKITRDSKVRLIRQGIVVYEGEIDSLKRYKDDVREVAQGYECGVTIKNFNDIKE
GDVIEAYIMQEVARA

Sequences:

>Translated_735_residues
MSKMRVYEYAKKHNVPSKDVIHKLKEMNIEVNNHMTMLEADVVEKLDHQYRVNSEKKAEKKTEKPKRPTPAKAADFADEE
MFEDKKETAKAKPAKKKGAVKGKETKKTEAQQQEKKLFQAAKKKGKGPMKGKKQAAPASKQAQQPAKKEKELPKKITFEG
SLTVAELAKKLGREPSEIIKKLFMLGVMATINQDLDKDAIELICSDYGVEVEEKVTIDETNFETIEIVDAPEDLVERPPV
VTIMGHVDHGKTTLLDAIRHSKVTEQEAGGITQHIGAYQVTVNGKKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADD
GVMPQTVEAINHAKAANVPIIVAINKMDKPEANPDRVMQELMEYNLVPEEWGGDTIFCKLSAKTQDGIDHLLEMILLVSE
MEELKANPNRRALGTVIEAKLDKGRGPVATLLVQAGTLKVGDPIVVGTTYGRVRAMVNDSGRRVKEAGPSMPVEITGLHD
VPQAGDRFMVFEDEKKARQIGEARAQRQLQEQRSVKTRVSLDDLFEQIKQGEMKELNLIVKADVQGSVEALVAALQKIDI
EGVRVKIIHAAVGAITESDILLATTSNAIVIGFNVRPDTNAKRAAESENVDIRLHRIIYNVIEEIEAAMKGMLDPEYEEK
VIGQAEVRQTFKVSKVGTIAGCYVTDGKITRDSKVRLIRQGIVVYEGEIDSLKRYKDDVREVAQGYECGVTIKNFNDIKE
GDVIEAYIMQEVARA
>Mature_734_residues
SKMRVYEYAKKHNVPSKDVIHKLKEMNIEVNNHMTMLEADVVEKLDHQYRVNSEKKAEKKTEKPKRPTPAKAADFADEEM
FEDKKETAKAKPAKKKGAVKGKETKKTEAQQQEKKLFQAAKKKGKGPMKGKKQAAPASKQAQQPAKKEKELPKKITFEGS
LTVAELAKKLGREPSEIIKKLFMLGVMATINQDLDKDAIELICSDYGVEVEEKVTIDETNFETIEIVDAPEDLVERPPVV
TIMGHVDHGKTTLLDAIRHSKVTEQEAGGITQHIGAYQVTVNGKKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADDG
VMPQTVEAINHAKAANVPIIVAINKMDKPEANPDRVMQELMEYNLVPEEWGGDTIFCKLSAKTQDGIDHLLEMILLVSEM
EELKANPNRRALGTVIEAKLDKGRGPVATLLVQAGTLKVGDPIVVGTTYGRVRAMVNDSGRRVKEAGPSMPVEITGLHDV
PQAGDRFMVFEDEKKARQIGEARAQRQLQEQRSVKTRVSLDDLFEQIKQGEMKELNLIVKADVQGSVEALVAALQKIDIE
GVRVKIIHAAVGAITESDILLATTSNAIVIGFNVRPDTNAKRAAESENVDIRLHRIIYNVIEEIEAAMKGMLDPEYEEKV
IGQAEVRQTFKVSKVGTIAGCYVTDGKITRDSKVRLIRQGIVVYEGEIDSLKRYKDDVREVAQGYECGVTIKNFNDIKEG
DVIEAYIMQEVARA

Specific function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 7

COG id: COG0532

COG function: function code J; Translation initiation factor 2 (IF-2; GTPase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-2 family [H]

Homologues:

Organism=Homo sapiens, GI53729339, Length=540, Percent_Identity=43.1481481481481, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI53729337, Length=540, Percent_Identity=43.1481481481481, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI84043963, Length=474, Percent_Identity=27.2151898734177, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI157426893, Length=228, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI18390331, Length=142, Percent_Identity=31.6901408450704, Blast_Score=67, Evalue=9e-11,
Organism=Escherichia coli, GI1789559, Length=600, Percent_Identity=52.3333333333333, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI2367247, Length=248, Percent_Identity=33.4677419354839, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1788922, Length=238, Percent_Identity=28.9915966386555, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI48994988, Length=146, Percent_Identity=35.6164383561644, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790412, Length=236, Percent_Identity=32.2033898305085, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789737, Length=236, Percent_Identity=32.2033898305085, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994658, Length=548, Percent_Identity=36.3138686131387, Blast_Score=328, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI212656558, Length=558, Percent_Identity=24.910394265233, Blast_Score=122, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557151, Length=220, Percent_Identity=31.8181818181818, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=246, Percent_Identity=34.1463414634146, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324550, Length=627, Percent_Identity=36.3636363636364, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319282, Length=482, Percent_Identity=25.5186721991701, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324761, Length=238, Percent_Identity=30.2521008403361, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323098, Length=177, Percent_Identity=31.0734463276836, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28572034, Length=610, Percent_Identity=38.5245901639344, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI160714833, Length=118, Percent_Identity=54.2372881355932, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24656849, Length=477, Percent_Identity=27.0440251572327, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI78706572, Length=225, Percent_Identity=29.7777777777778, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24582462, Length=148, Percent_Identity=31.7567567567568, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922690, Length=231, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: 1150 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006847
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000178
- InterPro:   IPR015760
- InterPro:   IPR023115
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF11987 IF-2; PF04760 IF2_N [H]

EC number: NA

Molecular weight: Translated: 81497; Mature: 81366

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS01176 IF2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMRVYEYAKKHNVPSKDVIHKLKEMNIEVNNHMTMLEADVVEKLDHQYRVNSEKKAEK
CCCCHHHHHHHHCCCCHHHHHHHHHHCCEEECCCEEHHHHHHHHHHHHHHCCCCHHHHHH
KTEKPKRPTPAKAADFADEEMFEDKKETAKAKPAKKKGAVKGKETKKTEAQQQEKKLFQA
HHCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHH
AKKKGKGPMKGKKQAAPASKQAQQPAKKEKELPKKITFEGSLTVAELAKKLGREPSEIIK
HHHCCCCCCCCCCCCCCCHHHHHCHHHHHHCCCCEEEECCCCCHHHHHHHHCCCHHHHHH
KLFMLGVMATINQDLDKDAIELICSDYGVEVEEKVTIDETNFETIEIVDAPEDLVERPPV
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECEEEEECCCCCEEEEECCCHHHHHCCCE
VTIMGHVDHGKTTLLDAIRHSKVTEQEAGGITQHIGAYQVTVNGKKITFLDTPGHEAFTT
EEEEECCCCCHHHHHHHHHHHCCCHHHCCCHHHHCCEEEEEECCCEEEEEECCCCHHHHH
MRARGAQVTDIVILVVAADDGVMPQTVEAINHAKAANVPIIVAINKMDKPEANPDRVMQE
HHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHH
LMEYNLVPEEWGGDTIFCKLSAKTQDGIDHLLEMILLVSEMEELKANPNRRALGTVIEAK
HHHCCCCCHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LDKGRGPVATLLVQAGTLKVGDPIVVGTTYGRVRAMVNDSGRRVKEAGPSMPVEITGLHD
HCCCCCCHHHHHEECCCEECCCCEEEECCHHHHEEECCCCCCCHHHCCCCCCEEEECCCC
VPQAGDRFMVFEDEKKARQIGEARAQRQLQEQRSVKTRVSLDDLFEQIKQGEMKELNLIV
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHEEEEE
KADVQGSVEALVAALQKIDIEGVRVKIIHAAVGAITESDILLATTSNAIVIGFNVRPDTN
EECCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCCCCEEEEECCCEEEEEEECCCCCC
AKRAAESENVDIRLHRIIYNVIEEIEAAMKGMLDPEYEEKVIGQAEVRQTFKVSKVGTIA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHCCCEE
GCYVTDGKITRDSKVRLIRQGIVVYEGEIDSLKRYKDDVREVAQGYECGVTIKNFNDIKE
EEEEECCEECCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
GDVIEAYIMQEVARA
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
SKMRVYEYAKKHNVPSKDVIHKLKEMNIEVNNHMTMLEADVVEKLDHQYRVNSEKKAEK
CCCHHHHHHHHCCCCHHHHHHHHHHCCEEECCCEEHHHHHHHHHHHHHHCCCCHHHHHH
KTEKPKRPTPAKAADFADEEMFEDKKETAKAKPAKKKGAVKGKETKKTEAQQQEKKLFQA
HHCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHH
AKKKGKGPMKGKKQAAPASKQAQQPAKKEKELPKKITFEGSLTVAELAKKLGREPSEIIK
HHHCCCCCCCCCCCCCCCHHHHHCHHHHHHCCCCEEEECCCCCHHHHHHHHCCCHHHHHH
KLFMLGVMATINQDLDKDAIELICSDYGVEVEEKVTIDETNFETIEIVDAPEDLVERPPV
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECEEEEECCCCCEEEEECCCHHHHHCCCE
VTIMGHVDHGKTTLLDAIRHSKVTEQEAGGITQHIGAYQVTVNGKKITFLDTPGHEAFTT
EEEEECCCCCHHHHHHHHHHHCCCHHHCCCHHHHCCEEEEEECCCEEEEEECCCCHHHHH
MRARGAQVTDIVILVVAADDGVMPQTVEAINHAKAANVPIIVAINKMDKPEANPDRVMQE
HHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHH
LMEYNLVPEEWGGDTIFCKLSAKTQDGIDHLLEMILLVSEMEELKANPNRRALGTVIEAK
HHHCCCCCHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LDKGRGPVATLLVQAGTLKVGDPIVVGTTYGRVRAMVNDSGRRVKEAGPSMPVEITGLHD
HCCCCCCHHHHHEECCCEECCCCEEEECCHHHHEEECCCCCCCHHHCCCCCCEEEECCCC
VPQAGDRFMVFEDEKKARQIGEARAQRQLQEQRSVKTRVSLDDLFEQIKQGEMKELNLIV
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHEEEEE
KADVQGSVEALVAALQKIDIEGVRVKIIHAAVGAITESDILLATTSNAIVIGFNVRPDTN
EECCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCCCCEEEEECCCEEEEEEECCCCCC
AKRAAESENVDIRLHRIIYNVIEEIEAAMKGMLDPEYEEKVIGQAEVRQTFKVSKVGTIA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHCCCEE
GCYVTDGKITRDSKVRLIRQGIVVYEGEIDSLKRYKDDVREVAQGYECGVTIKNFNDIKE
EEEEECCEECCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
GDVIEAYIMQEVARA
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3025563; 2265694 [H]