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The map label for this gene is hslU [H]

Identifier: 138894735

GI number: 138894735

Start: 1134322

End: 1135716

Strand: Direct

Name: hslU [H]

Synonym: GTNG_1067

Alternate gene names: 138894735

Gene position: 1134322-1135716 (Clockwise)

Preceding gene: 138894734

Following gene: 138894736

Centisome position: 31.95

GC content: 51.04

Gene sequence:

>1395_bases
ATGGCGGAAACACTGACTCCACGGCAAATTGTCGAGAGGCTCGATCAGTTTATTATCGGGCAAAAAGAGGCGAAAAAGGC
GGTGGCGATTGCGCTCCGCAACCGGTATCGCCGCAGTTTGCTCGATGAAAAATTGCGTGATGAAGTGATGCCGAAAAACA
TCTTAATGATTGGTCCGACCGGGGTCGGGAAGACGGAGATCGCCCGTCGGCTAGCTAAACTTGTCGGCGCGCCGTTTATC
AAAGTTGAGGCGACGAAATTTACCGAAGTCGGCTACGTTGGGCGAGACGTCGAATCGATGGTGCGCGATTTAGTGGAGAC
ATCGGTTAGGCTCGTGAAAGAACGAAAAATGAGCGAGGTGAAAGACCGGGCTGAGCAGCAAGCGAATAAGCGGCTTGTCG
AATTGCTCGTTCCCGGTAAGCAAAAGCAAACGATCAAAAATCCGCTCGAGCTCCTATTTGGCGGTCAAGCTAGCCAACCG
GACAACGGCCATAGCCACGACGATGAACAGGTGGAGAAAAAGCGGCGCCAAGTCGCTTGGCAGCTAGCCAACGGCCAACT
CGAAGATGAGATGGTGACGATTGAAATCGAGGAGCAGCCGCCCATGCTATTTGACTTTTTGCAAGGGGCGGGCATTGAGC
AGATGGGTGTCAACATGCAAGATGCGTTAGGCAGCCTCATGCCGAAACGGCGTAAAAAGCGGCGCCTGAAGGTGAGCGAA
GCGCGCAAGGTGCTCATCAATGAAGAAGCGCAAAAACTGATTGATATGGATGAAGTGACGCAAGAGGCAATCCGCCTTGC
TGAGCAGTCCGGCATCATTTTTATTGACGAAATTGATAAAATCGCCCGCGGCAAAGAGGTGTCCGGTTCGGCCGACGTCT
CTCGCGAAGGGGTGCAGCGCGATATTTTGCCGATCGTCGAAGGTTCAACCGTCATGACGAAATACGGGCCGGTCAAAACA
GACCATATTTTATTTATCGCTGCCGGCGCGTTCCATATGGCGAAGCCATCGGATTTGATCCCTGAGCTGCAAGGTCGTTT
TCCGATCCGTGTCGAACTGGCGAAACTTTCGGTTGACGATTTCGTAAGTATATTAGTCGAGCCGAATAACGCGCTCATTA
AACAATATCAGGCACTTTTGGCGACGGAAGGTATAAATCTCGAATTTTCTGACGATGCTATTCGTAAGATCGCTGAAGTG
GCGTTTGAAGTGAACCAGACGACCGACAATATCGGCGCGCGCCGGCTCCATACGATTTTAGAGAAGCTGCTCGAAGATTT
GCTGTTTGAGGCGCCGGATATCGGGCTTAACCGAGTCGTCATCACACCGCAATACGTCGAACAAAAACTCGGCAACATTG
TCAAAAACAAAGATTTAAGTGAGTTCATTTTATGA

Upstream 100 bases:

>100_bases
AGAGATTGCGAAAGCCGCGTTGGAGATTGCCGCTGACATTTGTGTCTATACGAACGGCCATATTATTGTCGAAGAGTTGT
AAAAAAGGAGGAGGCCGAAG

Downstream 100 bases:

>100_bases
GGAGGAGATGGAAAAGATGAATTTGCTAGAGAAAACGCGAAAAATTAACGCCATGCTGCAAAAAGCAGCCGGGCGGCCGG
TCAATTTCAAAGAAATGGCG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAETLTPRQIVERLDQFIIGQKEAKKAVAIALRNRYRRSLLDEKLRDEVMPKNILMIGPTGVGKTEIARRLAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRLVKERKMSEVKDRAEQQANKRLVELLVPGKQKQTIKNPLELLFGGQASQP
DNGHSHDDEQVEKKRRQVAWQLANGQLEDEMVTIEIEEQPPMLFDFLQGAGIEQMGVNMQDALGSLMPKRRKKRRLKVSE
ARKVLINEEAQKLIDMDEVTQEAIRLAEQSGIIFIDEIDKIARGKEVSGSADVSREGVQRDILPIVEGSTVMTKYGPVKT
DHILFIAAGAFHMAKPSDLIPELQGRFPIRVELAKLSVDDFVSILVEPNNALIKQYQALLATEGINLEFSDDAIRKIAEV
AFEVNQTTDNIGARRLHTILEKLLEDLLFEAPDIGLNRVVITPQYVEQKLGNIVKNKDLSEFIL

Sequences:

>Translated_464_residues
MAETLTPRQIVERLDQFIIGQKEAKKAVAIALRNRYRRSLLDEKLRDEVMPKNILMIGPTGVGKTEIARRLAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRLVKERKMSEVKDRAEQQANKRLVELLVPGKQKQTIKNPLELLFGGQASQP
DNGHSHDDEQVEKKRRQVAWQLANGQLEDEMVTIEIEEQPPMLFDFLQGAGIEQMGVNMQDALGSLMPKRRKKRRLKVSE
ARKVLINEEAQKLIDMDEVTQEAIRLAEQSGIIFIDEIDKIARGKEVSGSADVSREGVQRDILPIVEGSTVMTKYGPVKT
DHILFIAAGAFHMAKPSDLIPELQGRFPIRVELAKLSVDDFVSILVEPNNALIKQYQALLATEGINLEFSDDAIRKIAEV
AFEVNQTTDNIGARRLHTILEKLLEDLLFEAPDIGLNRVVITPQYVEQKLGNIVKNKDLSEFIL
>Mature_463_residues
AETLTPRQIVERLDQFIIGQKEAKKAVAIALRNRYRRSLLDEKLRDEVMPKNILMIGPTGVGKTEIARRLAKLVGAPFIK
VEATKFTEVGYVGRDVESMVRDLVETSVRLVKERKMSEVKDRAEQQANKRLVELLVPGKQKQTIKNPLELLFGGQASQPD
NGHSHDDEQVEKKRRQVAWQLANGQLEDEMVTIEIEEQPPMLFDFLQGAGIEQMGVNMQDALGSLMPKRRKKRRLKVSEA
RKVLINEEAQKLIDMDEVTQEAIRLAEQSGIIFIDEIDKIARGKEVSGSADVSREGVQRDILPIVEGSTVMTKYGPVKTD
HILFIAAGAFHMAKPSDLIPELQGRFPIRVELAKLSVDDFVSILVEPNNALIKQYQALLATEGINLEFSDDAIRKIAEVA
FEVNQTTDNIGARRLHTILEKLLEDLLFEAPDIGLNRVVITPQYVEQKLGNIVKNKDLSEFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=40.5405405405405, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=51.7391304347826, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786642, Length=227, Percent_Identity=34.3612334801762, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71988663, Length=278, Percent_Identity=27.3381294964029, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319704, Length=117, Percent_Identity=35.8974358974359, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648291, Length=244, Percent_Identity=31.9672131147541, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648289, Length=244, Percent_Identity=31.9672131147541, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52255; Mature: 52124

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETLTPRQIVERLDQFIIGQKEAKKAVAIALRNRYRRSLLDEKLRDEVMPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEIARRLAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRLVKERKMSEV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KDRAEQQANKRLVELLVPGKQKQTIKNPLELLFGGQASQPDNGHSHDDEQVEKKRRQVAW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QLANGQLEDEMVTIEIEEQPPMLFDFLQGAGIEQMGVNMQDALGSLMPKRRKKRRLKVSE
HHCCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCHHH
ARKVLINEEAQKLIDMDEVTQEAIRLAEQSGIIFIDEIDKIARGKEVSGSADVSREGVQR
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHHH
DILPIVEGSTVMTKYGPVKTDHILFIAAGAFHMAKPSDLIPELQGRFPIRVELAKLSVDD
HHHHHCCCCEEEEECCCCCCCCEEEEEECCHHCCCCHHHHHHHCCCCCEEEEEECCCHHH
FVSILVEPNNALIKQYQALLATEGINLEFSDDAIRKIAEVAFEVNQTTDNIGARRLHTIL
HHHHHCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EKLLEDLLFEAPDIGLNRVVITPQYVEQKLGNIVKNKDLSEFIL
HHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
AETLTPRQIVERLDQFIIGQKEAKKAVAIALRNRYRRSLLDEKLRDEVMPKNILMIGPT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEIARRLAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRLVKERKMSEV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KDRAEQQANKRLVELLVPGKQKQTIKNPLELLFGGQASQPDNGHSHDDEQVEKKRRQVAW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QLANGQLEDEMVTIEIEEQPPMLFDFLQGAGIEQMGVNMQDALGSLMPKRRKKRRLKVSE
HHCCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCHHH
ARKVLINEEAQKLIDMDEVTQEAIRLAEQSGIIFIDEIDKIARGKEVSGSADVSREGVQR
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHHH
DILPIVEGSTVMTKYGPVKTDHILFIAAGAFHMAKPSDLIPELQGRFPIRVELAKLSVDD
HHHHHCCCCEEEEECCCCCCCCEEEEEECCHHCCCCHHHHHHHCCCCCEEEEEECCCHHH
FVSILVEPNNALIKQYQALLATEGINLEFSDDAIRKIAEVAFEVNQTTDNIGARRLHTIL
HHHHHCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EKLLEDLLFEAPDIGLNRVVITPQYVEQKLGNIVKNKDLSEFIL
HHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA