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The map label for this gene is msrA [H]

Identifier: 134302795

GI number: 134302795

Start: 1890550

End: 1891239

Strand: Reverse

Name: msrA [H]

Synonym: FTW_2019

Alternate gene names: 134302795

Gene position: 1891239-1890550 (Counterclockwise)

Preceding gene: 134302796

Following gene: 134302794

Centisome position: 99.62

GC content: 28.7

Gene sequence:

>690_bases
ATGATTAAGAAGATTATTTATAGTTTATCAATACTATCTTGTAGTTTAGGTTTCTCAGCTGATAGTGATACTAAATATGA
AAAAGCTATATTTGCAGGTGGTTGTTTTTGGTGTTTAGAATCAGATTTTGAATATATGCAAAAACATCAAGATCTAAGTC
ATAATGGTATTATAAAGGTTATCTCTGGTTATGATGGTGGTTTGCAAAAAGATCCTACCTACAAAACAGTATCTGCAGGT
ATTACAAACTATAAAGAATCAGTTGAAGTCATATATGATCCTACTAAAATTAGCTATCAAGAGCTTGTAGAGTATTTTTA
TCGCCGTATAGATCCTACAGACTTTAAAGGACAATTTTGTGATAAAGGCAAGCAATATCAATCAGCTATATATTACAACA
ATGACAAACAAAAACAGGTTGCTGAAGAGGTTACTAAAAAATTAAAAGAAGAATTTAAAAAACATAATCAATCTGTATAT
ACTCAAATTTTACCATCTACACATTTTTATAAAGCTGAAAGTTACCATCAAGATTATCATCATAAAAATCCTAAAAGATA
TTGCTATTATCGTACCGGATGTGGTCGTGATCTAACAATAAATAAAGTTTGGCAAAATATAGATTGGAAATATAGTAATG
TAGTTCCATTTGATATACCATCTAGCTATGCAGAATGTTTAATAAGATAA

Upstream 100 bases:

>100_bases
ATTTAGAAAATTCTTAATATTTTAATCATCATCAAATTTATTTATTCAACATTTGTTTATATAATTTTTTAGTATCATAA
TTAAAATTAAGGATTATATT

Downstream 100 bases:

>100_bases
TAAAATGAAAGTAGTTGGTATAGCATCAAAAGTTTCTAATGATAGAGAAGATTTGCTTGAAGAAGCTTGGGAGCTTTTCT
TTAATAGTGAGGTATTAGAG

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MIKKIIYSLSILSCSLGFSADSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKVISGYDGGLQKDPTYKTVSAG
ITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFCDKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVY
TQILPSTHFYKAESYHQDYHHKNPKRYCYYRTGCGRDLTINKVWQNIDWKYSNVVPFDIPSSYAECLIR

Sequences:

>Translated_229_residues
MIKKIIYSLSILSCSLGFSADSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKVISGYDGGLQKDPTYKTVSAG
ITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFCDKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVY
TQILPSTHFYKAESYHQDYHHKNPKRYCYYRTGCGRDLTINKVWQNIDWKYSNVVPFDIPSSYAECLIR
>Mature_229_residues
MIKKIIYSLSILSCSLGFSADSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKVISGYDGGLQKDPTYKTVSAG
ITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFCDKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVY
TQILPSTHFYKAESYHQDYHHKNPKRYCYYRTGCGRDLTINKVWQNIDWKYSNVVPFDIPSSYAECLIR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=35.5828220858896, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=35.5828220858896, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=37.962962962963, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790665, Length=160, Percent_Identity=36.875, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533973, Length=159, Percent_Identity=37.7358490566038, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=35.5421686746988, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664627, Length=159, Percent_Identity=32.7044025157233, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45553131, Length=152, Percent_Identity=32.8947368421053, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24664631, Length=159, Percent_Identity=32.0754716981132, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26894; Mature: 26894

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIIYSLSILSCSLGFSADSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKV
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHCCCCCCCEEEE
ISGYDGGLQKDPTYKTVSAGITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFC
EECCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHH
DKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVYTQILPSTHFYKAESYHQDYH
CCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHH
HKNPKRYCYYRTGCGRDLTINKVWQNIDWKYSNVVPFDIPSSYAECLIR
CCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCEECCCCCHHHHHHHCC
>Mature Secondary Structure
MIKKIIYSLSILSCSLGFSADSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKV
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHCCCCCCCEEEE
ISGYDGGLQKDPTYKTVSAGITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFC
EECCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHH
DKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVYTQILPSTHFYKAESYHQDYH
CCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHH
HKNPKRYCYYRTGCGRDLTINKVWQNIDWKYSNVVPFDIPSSYAECLIR
CCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA