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The map label for this gene is nhaA [H]

Identifier: 134302771

GI number: 134302771

Start: 1861165

End: 1862088

Strand: Direct

Name: nhaA [H]

Synonym: FTW_1984

Alternate gene names: 134302771

Gene position: 1861165-1862088 (Clockwise)

Preceding gene: 134302769

Following gene: 134302772

Centisome position: 98.03

GC content: 35.06

Gene sequence:

>924_bases
ATGGAAAATAACATTTCCAACACAACACTAGAAAAATTAGCTCAAGCTTACCTAAAGGATATTAAGAGTAAGAGACGTTG
GCGTTTGTTTACGCGATTAATAATTATTCTAATGATTCTGCTACTGATAGTTCCTAGCTTATTTAGCTCATCTAAAGAGC
TAGTACCTCATATAGCTTTAATAAAAGTTAATGGAGTGATTGCTGATGATGCCGAAGCTAATGCTGAGAGAATTAACCAA
AGCCTTGATGATGCCTATGCAAATAAGTCTGTAAAAGGAGTAATTGTTGAAATAAATAGTCCAGGAGGCTCACCGGTACA
GTCTGATGAGATATACTCGCATATGCAATATTTACAGCATAAATATCCGACTATTCCTATGTATGCTGTATGTACAGATG
TTTGTGCTAGTGGCGGTTATTATATCGCTGCTGGGGCAAAAGACATTTATGCCAATAAGATGACGATAACGGGTTCAATA
GGAGTTATTGGTAGTGGTTTTGGTTTTACAGGGCTTATGGATAAATTAGGTATTGAGCGTAGAACATACACTTCAGGAGA
GAATAAGGATTTCTTGGATCCGTTTTCGCCACAAAAACCAGAGCAGACTGCACAATTTAAAGAACTTCTAGATCAAACTC
ATCAGGTTTTCATAGCTGCAGTAGAAAAATCTAGAGGAGATAGGCTAAAAGATAAGAATATAGATACAACATTCTCTGGT
GAACCTTTTAGTGGTATTCAAGCACAGCAAATGGGATTGATAGATGGTTTCGCTTCAGTTGACCAAATTAGAAATGAAAA
ATTTAATAACATTGATATTGTTGACTATACTCGACCACTTGATTTTTTAACAGCAGTATCACATAAATTAGGTAATAGCA
TTTATTATAAAGCTCTCTCAGAAACTAGCTTTAGTTTAAAATAA

Upstream 100 bases:

>100_bases
TGCTTTGGTTTCTAGTGTTGCTGTCATTATATTATCCCTATGATTTTTTGCTAAATAGATTTAAAATTGTTGATGAAATA
TTAACAAATATGGAGATAAA

Downstream 100 bases:

>100_bases
GTGTTTTAAGTGTTGAAACATACAATAACGATGATTATAATCGAAGTTATATTATGTTTTATAAACTAAACAAGCAAGGA
AGAAAAATTATGAAAAAAAC

Product: signal peptidase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MENNISNTTLEKLAQAYLKDIKSKRRWRLFTRLIIILMILLLIVPSLFSSSKELVPHIALIKVNGVIADDAEANAERINQ
SLDDAYANKSVKGVIVEINSPGGSPVQSDEIYSHMQYLQHKYPTIPMYAVCTDVCASGGYYIAAGAKDIYANKMTITGSI
GVIGSGFGFTGLMDKLGIERRTYTSGENKDFLDPFSPQKPEQTAQFKELLDQTHQVFIAAVEKSRGDRLKDKNIDTTFSG
EPFSGIQAQQMGLIDGFASVDQIRNEKFNNIDIVDYTRPLDFLTAVSHKLGNSIYYKALSETSFSLK

Sequences:

>Translated_307_residues
MENNISNTTLEKLAQAYLKDIKSKRRWRLFTRLIIILMILLLIVPSLFSSSKELVPHIALIKVNGVIADDAEANAERINQ
SLDDAYANKSVKGVIVEINSPGGSPVQSDEIYSHMQYLQHKYPTIPMYAVCTDVCASGGYYIAAGAKDIYANKMTITGSI
GVIGSGFGFTGLMDKLGIERRTYTSGENKDFLDPFSPQKPEQTAQFKELLDQTHQVFIAAVEKSRGDRLKDKNIDTTFSG
EPFSGIQAQQMGLIDGFASVDQIRNEKFNNIDIVDYTRPLDFLTAVSHKLGNSIYYKALSETSFSLK
>Mature_307_residues
MENNISNTTLEKLAQAYLKDIKSKRRWRLFTRLIIILMILLLIVPSLFSSSKELVPHIALIKVNGVIADDAEANAERINQ
SLDDAYANKSVKGVIVEINSPGGSPVQSDEIYSHMQYLQHKYPTIPMYAVCTDVCASGGYYIAAGAKDIYANKMTITGSI
GVIGSGFGFTGLMDKLGIERRTYTSGENKDFLDPFSPQKPEQTAQFKELLDQTHQVFIAAVEKSRGDRLKDKNIDTTFSG
EPFSGIQAQQMGLIDGFASVDQIRNEKFNNIDIVDYTRPLDFLTAVSHKLGNSIYYKALSETSFSLK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=170, Percent_Identity=30.5882352941176, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788064, Length=211, Percent_Identity=27.0142180094787, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34101; Mature: 34101

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNISNTTLEKLAQAYLKDIKSKRRWRLFTRLIIILMILLLIVPSLFSSSKELVPHIAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEE
IKVNGVIADDAEANAERINQSLDDAYANKSVKGVIVEINSPGGSPVQSDEIYSHMQYLQH
EEECCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
KYPTIPMYAVCTDVCASGGYYIAAGAKDIYANKMTITGSIGVIGSGFGFTGLMDKLGIER
CCCCCHHHHHHHHHHHCCCEEEEECCHHHHCCCEEEEECCCEEECCCCHHHHHHHHCCCC
RTYTSGENKDFLDPFSPQKPEQTAQFKELLDQTHQVFIAAVEKSRGDRLKDKNIDTTFSG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EPFSGIQAQQMGLIDGFASVDQIRNEKFNNIDIVDYTRPLDFLTAVSHKLGNSIYYKALS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCHHEEHHHH
ETSFSLK
CCCCCCC
>Mature Secondary Structure
MENNISNTTLEKLAQAYLKDIKSKRRWRLFTRLIIILMILLLIVPSLFSSSKELVPHIAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEE
IKVNGVIADDAEANAERINQSLDDAYANKSVKGVIVEINSPGGSPVQSDEIYSHMQYLQH
EEECCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
KYPTIPMYAVCTDVCASGGYYIAAGAKDIYANKMTITGSIGVIGSGFGFTGLMDKLGIER
CCCCCHHHHHHHHHHHCCCEEEEECCHHHHCCCEEEEECCCEEECCCCHHHHHHHHCCCC
RTYTSGENKDFLDPFSPQKPEQTAQFKELLDQTHQVFIAAVEKSRGDRLKDKNIDTTFSG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EPFSGIQAQQMGLIDGFASVDQIRNEKFNNIDIVDYTRPLDFLTAVSHKLGNSIYYKALS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCHHEEHHHH
ETSFSLK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA