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The map label for this gene is mdtN [H]

Identifier: 134302757

GI number: 134302757

Start: 1844871

End: 1845836

Strand: Reverse

Name: mdtN [H]

Synonym: FTW_1966

Alternate gene names: 134302757

Gene position: 1845836-1844871 (Counterclockwise)

Preceding gene: 134302758

Following gene: 134302756

Centisome position: 97.23

GC content: 28.36

Gene sequence:

>966_bases
ATGAAAATATCTAAGCTAATGGCTACCGTAATAATTTTATTCATAATCATTTTTCTTATATGTGTTTTTTTATTCTTTGA
TGCTAGTTTTGAAAGAGATGCTTATCTATATGCTGACTTTACTAGAGTAAATAGTGTTGAAAATGGGCAAGTAGAGAAAA
TATATATCAAAAAAGGATCATATGTAAAAAAAGGAGATACTCTATTTGTACTAGATTGTAGATATATAACAAAAGAGCTG
AATATACTAAAATCTCAAGAGAAAAAAATAGCTCTAGAACTCAAAGATATTGTTATTAAAATAAAACTTGCTGAAAAACA
AAGAGATCTAACAAAAGATAGCTTAATTGTTGAAAAAAGAAATTTTGAGAGATATAGAATCCTAATAAAAGAAGGAGCTG
TATCTGCCCAACAGAAAGATCTAGCTGAAAAAAGTCTAATATCTAGTGAATCTCAATTTGTTAGAGCTTGTCAAAATGTA
GATAATCTAAAAATAAGACAAAATGATTTATTATCAGATCAAAAAATAACACAATCAAAGATTGATCAAAAGCAATATTC
TTTAAGCAGATGCTCTGTCAAAGCTACAACTAATGGATATATTTCGAACTTTATACTAGAAGAAGGTGACTTTATTAAAA
AAGGACAAGAGCTATTTTCTATAGTTGATACTGATAAATGGTATGTTGTAGCTAATGTCAAAGAAAGTAATATTAAATAC
TTATCAGTTGGTCAAATAGTGACTATGACAACAAGTCTAACAGGGATTAAAAAATATAAAGGCAAAATAGTTGATATTGA
AAAAGGAATTACTAGACCAGAGTACAATAATTTCTCAGCTCTCTACAATATAGAAAGAAATATCGACTGGGTTAGGTTAG
ACTACAGATTTCCAGTGCTTATAGAGGTTTTATCGAAAGATACAAAAGAGTTTAGACTAGGTGGAGACGTGCATGTATGG
TTCTAA

Upstream 100 bases:

>100_bases
GAGAGTTTATAGCGTGACCAAAATCTACCTCTGAGATTTTTTTATATTTCAACGTGCTATAAGCGGTTCATCCCTATAAA
TAAACAACAGAGACTCCACT

Downstream 100 bases:

>100_bases
GTTCTATGATATCAAAAAGGAAGATTCCCTAGAAGTACTCTTAATAGCTATAGTAATGTCTGTAAGTGGCACGATAGCTA
TAATCATTAATGATGCACTA

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKISKLMATVIILFIIIFLICVFLFFDASFERDAYLYADFTRVNSVENGQVEKIYIKKGSYVKKGDTLFVLDCRYITKEL
NILKSQEKKIALELKDIVIKIKLAEKQRDLTKDSLIVEKRNFERYRILIKEGAVSAQQKDLAEKSLISSESQFVRACQNV
DNLKIRQNDLLSDQKITQSKIDQKQYSLSRCSVKATTNGYISNFILEEGDFIKKGQELFSIVDTDKWYVVANVKESNIKY
LSVGQIVTMTTSLTGIKKYKGKIVDIEKGITRPEYNNFSALYNIERNIDWVRLDYRFPVLIEVLSKDTKEFRLGGDVHVW
F

Sequences:

>Translated_321_residues
MKISKLMATVIILFIIIFLICVFLFFDASFERDAYLYADFTRVNSVENGQVEKIYIKKGSYVKKGDTLFVLDCRYITKEL
NILKSQEKKIALELKDIVIKIKLAEKQRDLTKDSLIVEKRNFERYRILIKEGAVSAQQKDLAEKSLISSESQFVRACQNV
DNLKIRQNDLLSDQKITQSKIDQKQYSLSRCSVKATTNGYISNFILEEGDFIKKGQELFSIVDTDKWYVVANVKESNIKY
LSVGQIVTMTTSLTGIKKYKGKIVDIEKGITRPEYNNFSALYNIERNIDWVRLDYRFPVLIEVLSKDTKEFRLGGDVHVW
F
>Mature_321_residues
MKISKLMATVIILFIIIFLICVFLFFDASFERDAYLYADFTRVNSVENGQVEKIYIKKGSYVKKGDTLFVLDCRYITKEL
NILKSQEKKIALELKDIVIKIKLAEKQRDLTKDSLIVEKRNFERYRILIKEGAVSAQQKDLAEKSLISSESQFVRACQNV
DNLKIRQNDLLSDQKITQSKIDQKQYSLSRCSVKATTNGYISNFILEEGDFIKKGQELFSIVDTDKWYVVANVKESNIKY
LSVGQIVTMTTSLTGIKKYKGKIVDIEKGITRPEYNNFSALYNIERNIDWVRLDYRFPVLIEVLSKDTKEFRLGGDVHVW
F

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=304, Percent_Identity=27.3026315789474, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789041, Length=309, Percent_Identity=24.2718446601942, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87081951, Length=295, Percent_Identity=21.6949152542373, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788711, Length=318, Percent_Identity=24.2138364779874, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37239; Mature: 37239

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISKLMATVIILFIIIFLICVFLFFDASFERDAYLYADFTRVNSVENGQVEKIYIKKGS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCCEEEEEEECCC
YVKKGDTLFVLDCRYITKELNILKSQEKKIALELKDIVIKIKLAEKQRDLTKDSLIVEKR
EEECCCEEEEEEHHHHHHHHHHHHCCCHHEEEEEEEEEEEEEECHHHHCCCHHHEEEECC
NFERYRILIKEGAVSAQQKDLAEKSLISSESQFVRACQNVDNLKIRQNDLLSDQKITQSK
CCCEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCCHHHHHH
IDQKQYSLSRCSVKATTNGYISNFILEEGDFIKKGQELFSIVDTDKWYVVANVKESNIKY
HHHHHHHHHHEEEEECCCCHHHHHEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEE
LSVGQIVTMTTSLTGIKKYKGKIVDIEKGITRPEYNNFSALYNIERNIDWVRLDYRFPVL
EEECEEEEEEEHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCEEEEEECCCHHH
IEVLSKDTKEFRLGGDVHVWF
HHHHCCCCHHEECCCEEEEEC
>Mature Secondary Structure
MKISKLMATVIILFIIIFLICVFLFFDASFERDAYLYADFTRVNSVENGQVEKIYIKKGS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCCEEEEEEECCC
YVKKGDTLFVLDCRYITKELNILKSQEKKIALELKDIVIKIKLAEKQRDLTKDSLIVEKR
EEECCCEEEEEEHHHHHHHHHHHHCCCHHEEEEEEEEEEEEEECHHHHCCCHHHEEEECC
NFERYRILIKEGAVSAQQKDLAEKSLISSESQFVRACQNVDNLKIRQNDLLSDQKITQSK
CCCEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCCHHHHHH
IDQKQYSLSRCSVKATTNGYISNFILEEGDFIKKGQELFSIVDTDKWYVVANVKESNIKY
HHHHHHHHHHEEEEECCCCHHHHHEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEE
LSVGQIVTMTTSLTGIKKYKGKIVDIEKGITRPEYNNFSALYNIERNIDWVRLDYRFPVL
EEECEEEEEEEHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCEEEEEECCCHHH
IEVLSKDTKEFRLGGDVHVWF
HHHHCCCCHHEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]