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The map label for this gene is sdaC [H]

Identifier: 134302744

GI number: 134302744

Start: 1828546

End: 1829769

Strand: Reverse

Name: sdaC [H]

Synonym: FTW_1951

Alternate gene names: 134302744

Gene position: 1829769-1828546 (Counterclockwise)

Preceding gene: 134302745

Following gene: 134302743

Centisome position: 96.38

GC content: 29.66

Gene sequence:

>1224_bases
ATGAAAAGAAATGAAGATTTAATGTGGTCCCTTAGTCTGTATGGTACAGCTATCGGTGCCGGTGTACTATTTTTGCCAAT
TCAAACTGGAATTTCAGGAATTATACCAATATTAGTGATATTAGTATTTATCTTCCCAATGGTGTTTTTATCACATCGTG
CATTATGTAGATTTGTGATATCTAACCCAAATACTAACTCTGATATCACAGTAGTTGCTGATGACTATTTTGGTAAGCTT
GGTGGAATTATTTTCAACATTTTATATCTATTTGCTATCTTGCCAATATTACTGGTTTATAGTGTTGGTATAACAAATAC
TCTGGCTAGTTTTTTTAAGTATCAGTTTCATTACGATATTCAAAATAGATTTCTTTTGAGTTTTTTTACTATACTTTCGC
TAGTTTTTATCATTAACTTTGGTCAGAAGCTTATCATCCGTGTTATGAGCCTTCTAGTTTTTCCATTTATCATCGCTTTG
CTAGTACTTTCATTATGGATGATTCCATATTGGAATATTGAGATACTGCAAAAGAGCATTGAGTACAATCATAGTTTTTC
TGGTATTTTGATAGCTATCTGGATAATTATGCCAATATTGATATTTTCTTTTAACCACTCACCGATTATCTCTTCTTTAG
CCGTATATGCAAAAACCAAATACAAACAAAATGCCGACAAAAAAGCCTCTAAGATAATTGCTTTTAGTAATATTCTAATG
ATTATTACTGTAGTTATATTTGTAATTAGCTCAATGCTTACCCTCTCTCCAAAAGAGCTAATAATCGCAAAAGAAGAGAA
TATTTCTATACTATCTTATCTAGCAAGTCATTTTAATAATTATTCTCTTGATTATGTAGCTCCAATAGTAGCTCTAGTTG
CTATGAGTAAGTCTTTTTTTGGTCATTATTTAGGTTCAAAAGAAGGTATAGATGGTCTAGTTTATAAAGTTACAAAAAAT
AAAATTAGTGAAAAAACTATAAAACCAATTACATTATCAATAGTGTTTTTATCATGCTGGCTAGTTGCTTATTTAAACCC
AAATATCTTAGATATGATATCTAGTATAGGTGGTCTAGTTTTAGCGGTGATACTGTTTATTATGCCTATTTATAGTATCT
ATAAAATAAAATATCTAAAGCCTTATAAAAACCTATTAGCAGATAGTTTTATACTTTTTGTTGGCATTATTGCACTATCA
TCGGCAATTTATGTTTTGTTGTAG

Upstream 100 bases:

>100_bases
TTCTTTTTACATTAAATTTTATTAATTATTTTTGAACTTGGTTTATGGATCGCTAATTTTAGCTTTCTACATAGGCTATT
TTTTTATTTAGATATTTACT

Downstream 100 bases:

>100_bases
GGTTATACTTAAAATTTGACATTTGACATAATAAGGTATAAATTGTATCCACCCAAATGGGGGCGAATATGGTTTCGACA
TGAATGTCAAAATCTAAGGT

Product: amino acid transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKRNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVISNPNTNSDITVVADDYFGKL
GGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDIQNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIAL
LVLSLWMIPYWNIEILQKSIEYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
IITVVIFVISSMLTLSPKELIIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFFGHYLGSKEGIDGLVYKVTKN
KISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLVLAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALS
SAIYVLL

Sequences:

>Translated_407_residues
MKRNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVISNPNTNSDITVVADDYFGKL
GGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDIQNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIAL
LVLSLWMIPYWNIEILQKSIEYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
IITVVIFVISSMLTLSPKELIIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFFGHYLGSKEGIDGLVYKVTKN
KISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLVLAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALS
SAIYVLL
>Mature_407_residues
MKRNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVISNPNTNSDITVVADDYFGKL
GGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDIQNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIAL
LVLSLWMIPYWNIEILQKSIEYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
IITVVIFVISSMLTLSPKELIIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFFGHYLGSKEGIDGLVYKVTKN
KISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLVLAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALS
SAIYVLL

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=409, Percent_Identity=45.9657701711491, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1789504, Length=425, Percent_Identity=41.6470588235294, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1789211, Length=403, Percent_Identity=37.468982630273, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI145693183, Length=393, Percent_Identity=24.9363867684478, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789961, Length=393, Percent_Identity=23.9185750636132, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 45853; Mature: 45853

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVI
CCCCCCCEEEHHHHHHHHHCCHHEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNPNTNSDITVVADDYFGKLGGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDI
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
QNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIALLVLSLWMIPYWNIEILQKSI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IITVVIFVISSMLTLSPKELIIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFF
HHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GHYLGSKEGIDGLVYKVTKNKISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLV
HHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALSSAIYVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVI
CCCCCCCEEEHHHHHHHHHCCHHEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNPNTNSDITVVADDYFGKLGGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDI
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
QNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIALLVLSLWMIPYWNIEILQKSI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IITVVIFVISSMLTLSPKELIIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFF
HHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GHYLGSKEGIDGLVYKVTKNKISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLV
HHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALSSAIYVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]