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The map label for this gene is ribAB [H]

Identifier: 134302739

GI number: 134302739

Start: 1822829

End: 1824040

Strand: Reverse

Name: ribAB [H]

Synonym: FTW_1944

Alternate gene names: 134302739

Gene position: 1824040-1822829 (Counterclockwise)

Preceding gene: 134302740

Following gene: 134302738

Centisome position: 96.08

GC content: 35.81

Gene sequence:

>1212_bases
ATGTTTGAGCAAATAAAAAATAATGTTGAGAATGCCATAGAAGCTCTTAAGCAAGGCAAACCCGTAGTTGTACTTGATGA
TTATGATAGAGAAAATGAGGGTGATCTAATTCTACCGGGTCAAAAAGCCACAGAAGAAAATATCGCATTTATGCTTGAGC
ATACAAGTGGCATCATTTGTTTGGCAATGGACTCAAAGAAAGCACGAGAATTAAATCTAACGCCAATGGTAGCTGCTGAC
CAAAACAATAGTACTTTTACAACTCCTTTTACTGTAACTATAGAGGCTAAAGAAGGGGTAACTACAGGAGTATCGGCAAA
GGATAGAGCACATACTATTCAAGTTGCATCAAAAGCTGATGCTAAAGCAGAAGAATTAGCTAGACCTGGACATATATTCC
CTCTTATAGCCAATGATAAAGGCGTACTTGGTAGAAATGGTCATACTGAGGCAACTGTTGATCTTATGAAACTAAGTGGT
TTTAATAGCGCTGGAGTTCTATGTGAGCTAATGAATAAAGATGGCACCATGATGAAAGCTGCTGAACTAGAAGCATTTGC
TAAAAAGCACGATCTGCCTCTTTTAACTATTGCAGAGCTTTACCAATATCGTTTAGCAACTGAAATTTTTGTCACGAAAA
TGGCAAGCTCTACTATACCATTCAAGAAAATTGGCGAATTGGAAATGAGTGTGTATAAAGATAACTTTAGTGGTGATGAA
GTTGTTGTTTTATCTAAACCTTATTCTGGTAATAATCCTTTAGTAAGAATGCATTCATCTTGCATAACAGGAGATATTTT
TGGCTCGCTACGCTGTGACTGCCAAGATCAATTACATAAAGGAATTGAAATGATTAGCGAAGAGGGTGGCTTTTTTATAT
ATCTTGACCAAGAAGGTAGAGGTATTGGTTTAACAAATAAGCTTAAAGCCTATAATTTGCAGATGAATGAAAATATGGAC
ACTCTTGAAGCTAATTTAGCTCTTGGCTTACCCGCTGACGCAAGAAAATACGATCTAGCTATACAAGTCCTAAAATATAA
CAATGTCAACCGCTGCCGATTAATATCTAATAATCCTGAAAAGCTAGCTGCTCTTAGAAACGTTGATATAGAAACACAAC
CAGTATATTGTGAGGCATTTGTAAACTCTCACAATAGAAACTACTTGATAACTAAAAAAATTAAAGCAAAACATACAATT
AAAGGAATATAG

Upstream 100 bases:

>100_bases
GTTACTATCGCAAAAAACTATAGTAATGGTTCTATGGTAAATCTTGAAGCTGATGCAACAGGTAAATATATCTATAAATA
TATACAAGGATTTAAAGAAA

Downstream 100 bases:

>100_bases
GTATAAATTATGAGAAAATTAGCAATCGTTGTAAGTGAATTTAACTCTTTGATAACTGATAAAATGCTTGAGGGTGCATT
AGAAGAAGCATATGCTCAAG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MFEQIKNNVENAIEALKQGKPVVVLDDYDRENEGDLILPGQKATEENIAFMLEHTSGIICLAMDSKKARELNLTPMVAAD
QNNSTFTTPFTVTIEAKEGVTTGVSAKDRAHTIQVASKADAKAEELARPGHIFPLIANDKGVLGRNGHTEATVDLMKLSG
FNSAGVLCELMNKDGTMMKAAELEAFAKKHDLPLLTIAELYQYRLATEIFVTKMASSTIPFKKIGELEMSVYKDNFSGDE
VVVLSKPYSGNNPLVRMHSSCITGDIFGSLRCDCQDQLHKGIEMISEEGGFFIYLDQEGRGIGLTNKLKAYNLQMNENMD
TLEANLALGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDIETQPVYCEAFVNSHNRNYLITKKIKAKHTI
KGI

Sequences:

>Translated_403_residues
MFEQIKNNVENAIEALKQGKPVVVLDDYDRENEGDLILPGQKATEENIAFMLEHTSGIICLAMDSKKARELNLTPMVAAD
QNNSTFTTPFTVTIEAKEGVTTGVSAKDRAHTIQVASKADAKAEELARPGHIFPLIANDKGVLGRNGHTEATVDLMKLSG
FNSAGVLCELMNKDGTMMKAAELEAFAKKHDLPLLTIAELYQYRLATEIFVTKMASSTIPFKKIGELEMSVYKDNFSGDE
VVVLSKPYSGNNPLVRMHSSCITGDIFGSLRCDCQDQLHKGIEMISEEGGFFIYLDQEGRGIGLTNKLKAYNLQMNENMD
TLEANLALGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDIETQPVYCEAFVNSHNRNYLITKKIKAKHTI
KGI
>Mature_403_residues
MFEQIKNNVENAIEALKQGKPVVVLDDYDRENEGDLILPGQKATEENIAFMLEHTSGIICLAMDSKKARELNLTPMVAAD
QNNSTFTTPFTVTIEAKEGVTTGVSAKDRAHTIQVASKADAKAEELARPGHIFPLIANDKGVLGRNGHTEATVDLMKLSG
FNSAGVLCELMNKDGTMMKAAELEAFAKKHDLPLLTIAELYQYRLATEIFVTKMASSTIPFKKIGELEMSVYKDNFSGDE
VVVLSKPYSGNNPLVRMHSSCITGDIFGSLRCDCQDQLHKGIEMISEEGGFFIYLDQEGRGIGLTNKLKAYNLQMNENMD
TLEANLALGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDIETQPVYCEAFVNSHNRNYLITKKIKAKHTI
KGI

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=55, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=39.2857142857143, Blast_Score=121, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=43.7810945273632, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319438, Length=177, Percent_Identity=34.4632768361582, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44584; Mature: 44584

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEQIKNNVENAIEALKQGKPVVVLDDYDRENEGDLILPGQKATEENIAFMLEHTSGIIC
CCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCCCCCCCCEEEEEECCCCEEE
LAMDSKKARELNLTPMVAADQNNSTFTTPFTVTIEAKEGVTTGVSAKDRAHTIQVASKAD
EEECCCCCCEECCCEEEEECCCCCEEECEEEEEEEECCCCCCCCCCCCCCEEEEEECCCC
AKAEELARPGHIFPLIANDKGVLGRNGHTEATVDLMKLSGFNSAGVLCELMNKDGTMMKA
CCHHHHCCCCCEEEEEECCCCCCCCCCCCHHEEEEEEECCCCCCCCEEEEECCCCCEEEH
AELEAFAKKHDLPLLTIAELYQYRLATEIFVTKMASSTIPFKKIGELEMSVYKDNFSGDE
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEEECCCCCCE
VVVLSKPYSGNNPLVRMHSSCITGDIFGSLRCDCQDQLHKGIEMISEEGGFFIYLDQEGR
EEEEECCCCCCCCEEEEECCEECCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEECCCCC
GIGLTNKLKAYNLQMNENMDTLEANLALGLPADARKYDLAIQVLKYNNVNRCRLISNNPE
CCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCCEEEEECCCHH
KLAALRNVDIETQPVYCEAFVNSHNRNYLITKKIKAKHTIKGI
HHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MFEQIKNNVENAIEALKQGKPVVVLDDYDRENEGDLILPGQKATEENIAFMLEHTSGIIC
CCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCCCCCCCCEEEEEECCCCEEE
LAMDSKKARELNLTPMVAADQNNSTFTTPFTVTIEAKEGVTTGVSAKDRAHTIQVASKAD
EEECCCCCCEECCCEEEEECCCCCEEECEEEEEEEECCCCCCCCCCCCCCEEEEEECCCC
AKAEELARPGHIFPLIANDKGVLGRNGHTEATVDLMKLSGFNSAGVLCELMNKDGTMMKA
CCHHHHCCCCCEEEEEECCCCCCCCCCCCHHEEEEEEECCCCCCCCEEEEECCCCCEEEH
AELEAFAKKHDLPLLTIAELYQYRLATEIFVTKMASSTIPFKKIGELEMSVYKDNFSGDE
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEEECCCCCCE
VVVLSKPYSGNNPLVRMHSSCITGDIFGSLRCDCQDQLHKGIEMISEEGGFFIYLDQEGR
EEEEECCCCCCCCEEEEECCEECCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEECCCCC
GIGLTNKLKAYNLQMNENMDTLEANLALGLPADARKYDLAIQVLKYNNVNRCRLISNNPE
CCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCCEEEEECCCHH
KLAALRNVDIETQPVYCEAFVNSHNRNYLITKKIKAKHTIKGI
HHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA