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The map label for this gene is lpxC

Identifier: 134302703

GI number: 134302703

Start: 1785598

End: 1786458

Strand: Reverse

Name: lpxC

Synonym: FTW_1902

Alternate gene names: 134302703

Gene position: 1786458-1785598 (Counterclockwise)

Preceding gene: 134302704

Following gene: 134302701

Centisome position: 94.1

GC content: 34.96

Gene sequence:

>861_bases
ATGATGAAACAAAAAACTATAGCAAAAGAATTCTCTGTAACCGGTGTTGGTTTACATTCTGGTGTAGATGTTTCTATGAC
TGTTAAACCAGCTGATATTGATAGCGGTATAGTATTTCGTCGTGCTGATTTAACTCCAGTTGTTGATATCAAAGTTACTC
CATCTAGTATTAAAGAAGCTATCATGTGTACTCTTTTGACAAAAGATGGCGATCAAAACCTATCAGTATCAACAATTGAG
CACTTAATGTCAGCATTTGCTATGTTTGAGGTTGATAATGTATTGATTGAGGTTAATGCTCCAGAGTTGCCAGTAATGGA
TGGTAGTTCATATGAATTTACACAGTTGCTAAAACAAGTTGGTATCGTTGAGCAGAATTCTGCTAGAAAAGGTATCAAAA
TCTTAAAACCTGTAAGAGTTGAGCATGAAGATAAGTTTGCTGAAGTTCTACCTAGTGATACATTAAAATATGAGTTTAAA
ATTCACTGGGATCATCCTGTAATTGCAGCGACAAATGATCATATAGTTTTTGAGTATGATCTTGATGAGTATATTAAGAT
GGTTTCAAAGGCTAGAACATTTGGCTTCTATGAGCAGCTTGCATATTTACATCAAAACAACCTTGCTAAAGGAGCATCGT
TAGATAATGCTGTTGGTGTTACTAATGAAGGTGTCCTTAACGAAGGCGGTTTGCGTTATGATGATGAGTTTGTCAGACAT
AAGCTTTTAGATGCAATTGGTGATTTTTATGTTGGTGGTTATATCTTAGGTCATTTCAACTGTTTTAAGTCTGGACATAC
TCTTAATAACAAACTTCTACATGCTGTCTTTGCTGATAAAGATGCGTGGGAATACATTTAG

Upstream 100 bases:

>100_bases
GGCGCTAGTAATGCACCAAAAACTGATTCTGATGATGTAAATAAATCAGATATCCCTAGTTTCTTAAGAAGAAGATAATA
AAAACCAAAATTAAGAGAGA

Downstream 100 bases:

>100_bases
GTTTTTTAAACTTCTAATCTGTTAAAATTATATTTTGATCCTTTATATCAATTGCGAGAGCTTGTTTAATAAGCTTTGTA
TTCTCATCATTATGAATTTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEAIMCTLLTKDGDQNLSVSTIE
HLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQVGIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFK
IHWDHPVIAATNDHIVFEYDLDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRH
KLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI

Sequences:

>Translated_286_residues
MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEAIMCTLLTKDGDQNLSVSTIE
HLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQVGIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFK
IHWDHPVIAATNDHIVFEYDLDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRH
KLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI
>Mature_286_residues
MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEAIMCTLLTKDGDQNLSVSTIE
HLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQVGIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFK
IHWDHPVIAATNDHIVFEYDLDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRH
KLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=287, Percent_Identity=45.6445993031359, Blast_Score=280, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_FRAT1 (Q14JP5)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666381.1
- ProteinModelPortal:   Q14JP5
- SMR:   Q14JP5
- STRING:   Q14JP5
- GeneID:   4199571
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0189
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q14JP5
- ProtClustDB:   PRK13186
- BioCyc:   FTUL393115:FTF0189-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31991; Mature: 31991

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEA
CCCCHHHHHHHCEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCEEEEEEECHHHHHHH
IMCTLLTKDGDQNLSVSTIEHLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQV
HEEEEEECCCCCCCCHHHHHHHHHHHHHHEECEEEEEECCCCCCEECCCCCHHHHHHHHC
GIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFKIHWDHPVIAATNDHIVFEYD
CCCCCCCCCCCCEEECCCCCCCCHHHHHHCCCCCEEEEEEEEECCCEEEECCCCEEEEEC
LDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI
HHHHHHHHHHHCCEEEEEHHHHCCCCCCCHHHEEEEECCCCCCCCC
>Mature Secondary Structure
MMKQKTIAKEFSVTGVGLHSGVDVSMTVKPADIDSGIVFRRADLTPVVDIKVTPSSIKEA
CCCCHHHHHHHCEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCEEEEEEECHHHHHHH
IMCTLLTKDGDQNLSVSTIEHLMSAFAMFEVDNVLIEVNAPELPVMDGSSYEFTQLLKQV
HEEEEEECCCCCCCCHHHHHHHHHHHHHHEECEEEEEECCCCCCEECCCCCHHHHHHHHC
GIVEQNSARKGIKILKPVRVEHEDKFAEVLPSDTLKYEFKIHWDHPVIAATNDHIVFEYD
CCCCCCCCCCCCEEECCCCCCCCHHHHHHCCCCCEEEEEEEEECCCEEEECCCCEEEEEC
LDEYIKMVSKARTFGFYEQLAYLHQNNLAKGASLDNAVGVTNEGVLNEGGLRYDDEFVRH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KLLDAIGDFYVGGYILGHFNCFKSGHTLNNKLLHAVFADKDAWEYI
HHHHHHHHHHHCCEEEEEHHHHCCCCCCCHHHEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA