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The map label for this gene is pyrH

Identifier: 134302595

GI number: 134302595

Start: 1661017

End: 1661766

Strand: Reverse

Name: pyrH

Synonym: FTW_1767

Alternate gene names: 134302595

Gene position: 1661766-1661017 (Counterclockwise)

Preceding gene: 134302596

Following gene: 134302594

Centisome position: 87.53

GC content: 36.8

Gene sequence:

>750_bases
ATGTCTAATGATTCGTCAGAATGTTCTCAAAAACTCCCTAAACTTAAGAGAATTCTTCTTAAGTTAAGTGGAGAATCTTT
ATCTGCAGATCAGGGTTTTGGTATAAATGTTGAATCTGCTCAACCTATCATAAATCAGATTAAAACTCTTACTAATTTTG
GTGTTGAGCTTGCTTTAGTGGTTGGCGGTGGTAATATTTTGCGTGGTGGTAGAGCTAATTTTGGTAACAAAATTAGAAGA
GCTACTGCTGACTCAATGGGGATGATTGCTACTATGATTAATGCTTTAGCTCTTCGTGATATGCTTATTAGTGAAGGTGT
TGATGCTGAGGTTTTTTCAGCAAAAGGAGTGGATGGGTTGTTGAAAGTTGCTAGTGCGCATGAATTTAATCAAGAACTTG
CCAAGGGTAGGGTTTTGATATTTGCAGGTGGTACTGGTAACCCATTTGTAACAACTGATACTACTGCTAGTTTAAGAGCT
GTTGAAATTGGTGCTGATGCTTTGTTAAAGGCTACGACAGTTAATGGCGTGTATGATAAAGACCCAAACAAATATTCAGA
TGCTAAGCGTTTTGATAAAGTCACATTTTCAGAAGTGGTTAGTAAAGAACTTAATGTGATGGATTTGGGAGCATTTACTC
AGTGTAGAGATTTCGGTATTCCGATATATGTATTTGATTTAACTCAGCCTAACGCTTTAGTTGATGCTGTTTTGGACTCA
AAGTATGGTACTTGGGTTACTTTAGACTAA

Upstream 100 bases:

>100_bases
TAAAGTAGTTAATTTCATCAGATTAGATGTTGGTGAAGGTATCGAGAAGAAAGAAGAAGACTTCGCAGCAGAGGTGATGA
GTCAAATTAAAGGTTAATAT

Downstream 100 bases:

>100_bases
TTAATTTTTTTAAAAAGGATTATTTTTTATGATAAATGATATTCTAAAAGATGCTGAGAATAGAATGAAAAAATCATTAG
AGGTTTTAGCTGATGATTTG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALVVGGGNILRGGRANFGNKIRR
ATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGLLKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRA
VEIGADALLKATTVNGVYDKDPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDS
KYGTWVTLD

Sequences:

>Translated_249_residues
MSNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALVVGGGNILRGGRANFGNKIRR
ATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGLLKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRA
VEIGADALLKATTVNGVYDKDPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDS
KYGTWVTLD
>Mature_248_residues
SNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALVVGGGNILRGGRANFGNKIRRA
TADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGLLKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRAV
EIGADALLKATTVNGVYDKDPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDSK
YGTWVTLD

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=46.1864406779661, Blast_Score=202, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_FRAT1 (Q14JD0)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666496.1
- ProteinModelPortal:   Q14JD0
- SMR:   Q14JD0
- STRING:   Q14JD0
- GeneID:   4200592
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0315
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK14556
- BioCyc:   FTUL393115:FTF0315-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26660; Mature: 26529

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: BINDING 63-63 BINDING 64-64 BINDING 68-68 BINDING 84-84 BINDING 172-172 BINDING 178-178 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
VGGGNILRGGRANFGNKIRRATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGL
EECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
LKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRAVEIGADALLKATTVNGVYDK
HHHHHHHHHHHHHHCCEEEEEECCCCCCCEEECCCCCEEEEEECCHHHEEEEEECCCCCC
DPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDS
CCCCHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHCCCEEEEEECCCCHHHHHHHHCC
KYGTWVTLD
CCCCEEEEC
>Mature Secondary Structure 
SNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
VGGGNILRGGRANFGNKIRRATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGL
EECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
LKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRAVEIGADALLKATTVNGVYDK
HHHHHHHHHHHHHHCCEEEEEECCCCCCCEEECCCCCEEEEEECCHHHEEEEEECCCCCC
DPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDS
CCCCHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHCCCEEEEEECCCCHHHHHHHHCC
KYGTWVTLD
CCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA