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The map label for this gene is ndk

Identifier: 134302544

GI number: 134302544

Start: 1618907

End: 1619329

Strand: Reverse

Name: ndk

Synonym: FTW_1707

Alternate gene names: 134302544

Gene position: 1619329-1618907 (Counterclockwise)

Preceding gene: 134302545

Following gene: 134302543

Centisome position: 85.3

GC content: 35.93

Gene sequence:

>423_bases
ATGACTAAACAAAGAACTTTATCTATAATTAAGCCAGATGCTGTAGAGAAAAATGTAATTGGTGAGATCTATAGCCGTTT
TGAGAAAGCAGGATTAAGAATTATTGCAGCTAAAATGAAGCATTTGTCAAAAGCAGAAGCTGAAAGATTTTATGCAGTAC
ATAAAGATAGACCTTTTTTTAGTGCGCTTGTTGAGTTTATGATTTCAGGTCCTGTGATGATACAAGTTTTAGAAGGTGAA
AATGCAATAGCAAAAAACCGTGAGTTAATGGGTGCAACAAACCCTAAAGAAGCTAAAGCAGGCACTATTAGAGCCGATTT
TGCTGATAGTATCGATGCAAATGCTGTCCATGGCTCAGATGCAGAAGATACAGCAGCACAAGAGATAAGATATTTCTTTA
GTGATACTGAGATTTTCGGCTAA

Upstream 100 bases:

>100_bases
AGCAGCTATCGAAAATTCTAATAATTAGTCACTACTTTTGATATTTCATGAATAAAAGTGCTATAATTTGACTTAATTAA
CTATTGGAGAATAATTTAAA

Downstream 100 bases:

>100_bases
GATATAATCTGATCTAATAAATATTTAGGAGGAGATTGGAAATGAGTTGGTTAACTAGAGTAATTGGTAGAAGTCTTGGT
TTAGAAGCGCAGAAAAAAGA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAERFYAVHKDRPFFSALVEFMISGPVMIQVLEGE
NAIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSDAEDTAAQEIRYFFSDTEIFG

Sequences:

>Translated_140_residues
MTKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAERFYAVHKDRPFFSALVEFMISGPVMIQVLEGE
NAIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSDAEDTAAQEIRYFFSDTEIFG
>Mature_139_residues
TKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAERFYAVHKDRPFFSALVEFMISGPVMIQVLEGEN
AIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSDAEDTAAQEIRYFFSDTEIFG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=42.962962962963, Blast_Score=126, Evalue=5e-30,
Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=42.962962962963, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=42.962962962963, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=42.962962962963, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=42.962962962963, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=42.2222222222222, Blast_Score=125, Evalue=9e-30,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=42.2222222222222, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=39.7058823529412, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=137, Percent_Identity=37.956204379562, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=137, Percent_Identity=37.956204379562, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.7647058823529, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=33.5766423357664, Blast_Score=73, Evalue=8e-14,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=33.0882352941176, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=57.2463768115942, Blast_Score=176, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=43.7037037037037, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=40, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=42.6470588235294, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=34.5864661654135, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_FRAT1 (Q14J74)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666552.1
- ProteinModelPortal:   Q14J74
- SMR:   Q14J74
- STRING:   Q14J74
- GeneID:   4200238
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0373c
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q14J74
- ProtClustDB:   PRK00668
- BioCyc:   FTUL393115:FTF0373C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15527; Mature: 15396

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAERFYAVHKDRPFF
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SALVEFMISGPVMIQVLEGENAIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCHHHCCHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
AEDTAAQEIRYFFSDTEIFG
CHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKQRTLSIIKPDAVEKNVIGEIYSRFEKAGLRIIAAKMKHLSKAEAERFYAVHKDRPFF
CCCCCEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SALVEFMISGPVMIQVLEGENAIAKNRELMGATNPKEAKAGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCHHHCCHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
AEDTAAQEIRYFFSDTEIFG
CHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA