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The map label for this gene is accC [H]

Identifier: 134302449

GI number: 134302449

Start: 1500686

End: 1502041

Strand: Reverse

Name: accC [H]

Synonym: FTW_1597

Alternate gene names: 134302449

Gene position: 1502041-1500686 (Counterclockwise)

Preceding gene: 134302450

Following gene: 134302448

Centisome position: 79.12

GC content: 36.73

Gene sequence:

>1356_bases
ATGATTAAAAAAGTACTGATTGCCAATAGAGGTGAAATAGCTCTTAGAATTTTAAGAGCTTGTAGAGAGTTGGGAATTAA
GACAGTCGCTGTGTATTCTACAGCTGATGCTAACCTTATGCATGTCAAACTAGCTGATGAAGCAGTTTGTATAGGTCCTC
CTGCTCCTAATCTTAGTTATCTAAATATCCAAGCTATTATAACTGCCGCTGAAATTACTAATGCTGATGCGATACATCCA
GGTTATGGTTTCTTATCAGAAAATGCAAAATTTGCTAAAGCTGTTGAAGAAAGTAGCTTTATATTTATCGGTCCACGTGC
AGAAAGCATAGAGATAATGGGCGATAAAGTTGAAGCTATTAGATATATGAAAAAAGCTGGTGTTCCATGTGTGCCAGGTT
CAGGCAGTCCATTAGGCAGCGATGAAAAGAAAAACTTAGAAATTGCTGAAAAAATCGGCTATCCAGTTATTATTAAAGCT
GCTGGTGGCGGTGGCGGTCGCGGAATGAGTATCGTTAGAAAGAAAGAAGATCTTATTAACGCTATTTCTCTAACAAAGAG
TGAAGCGAGAATAGCTTTCAATAATGATATGGTTTATATGGAAAAATTCTTAGAAAACCCTCGCCATATTGAAATTCAAG
TTTTTGGTGATGGTGAAGGTAATGCCGTATATCTATTTGAAAGAGATTGTTCTACTCAAAGAAGACACCAAAAAGTTATT
GAAGAAGCTCCAGCAATCGGTCTTTCCGACGAGGAAAGAAAGCGTATTGGTGAGCAGTGTGTTAGCGCATGTAAGATATT
AAAATATCGTGGTGCTGGTACTTTTGAGTTCTTATATGAGAATGGTGAATTCTACTTTATTGAGATGAATACTAGAATTC
AAGTGGAGCATCCTGTTACTGAGTCAATAACTTCTACAGATCTTATCAAAGAGCAAATCAGAGTTGCTAATGGTGAAGGT
CTAAGTTGGAAACAAGAAGATATTGCTATAGTAGGTCATGCAATTGAGTGTAGAATAAACGCCGAAGATCCTGAAAGAAT
GATTCCTTCACCTGGTAAGATCGATATGTATCATCCGCCAGCAGGACCTAGAGTGCGTGTGGACTCACATATATATTCAG
GCTATGTTGTTCCGCCGAATTATGACTCAATGATAGCTAAAGTTATCGTACGTGGTCATAATAGAGAAACAGCATTACAG
AAAATGCGCGCAGCTTTAGAAGAGATGGTGATTAATGGTATTAAGACAAACATACCTCTTCATCAAGAAATTCTAAATAA
TGAAGATTTTATTAAGGGTGGAACTAATATCCATTTCTTAGAGAAATTCTTAGAACAAAAAAACAAAGCTAAATAA

Upstream 100 bases:

>100_bases
GTTCAATTTGATCAACCTCTATTTATTATTGAATAATAAGCAATAAGTGACAATTAAAAATAGAGACTTCAGGTATAAAC
TTTTTAAAAGGTAATACAAA

Downstream 100 bases:

>100_bases
CTAAATCTATCTTTATATATATCTGCATTTAATTTTTACCTTTTTTCTTATATAATTTTGACTAGTATTAAATAACTAGT
TTATTGTAAAATTATGCATA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSYLNIQAIITAAEITNADAIHP
GYGFLSENAKFAKAVEESSFIFIGPRAESIEIMGDKVEAIRYMKKAGVPCVPGSGSPLGSDEKKNLEIAEKIGYPVIIKA
AGGGGGRGMSIVRKKEDLINAISLTKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTESITSTDLIKEQIRVANGEG
LSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPPAGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQ
KMRAALEEMVINGIKTNIPLHQEILNNEDFIKGGTNIHFLEKFLEQKNKAK

Sequences:

>Translated_451_residues
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSYLNIQAIITAAEITNADAIHP
GYGFLSENAKFAKAVEESSFIFIGPRAESIEIMGDKVEAIRYMKKAGVPCVPGSGSPLGSDEKKNLEIAEKIGYPVIIKA
AGGGGGRGMSIVRKKEDLINAISLTKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTESITSTDLIKEQIRVANGEG
LSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPPAGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQ
KMRAALEEMVINGIKTNIPLHQEILNNEDFIKGGTNIHFLEKFLEQKNKAK
>Mature_451_residues
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSYLNIQAIITAAEITNADAIHP
GYGFLSENAKFAKAVEESSFIFIGPRAESIEIMGDKVEAIRYMKKAGVPCVPGSGSPLGSDEKKNLEIAEKIGYPVIIKA
AGGGGGRGMSIVRKKEDLINAISLTKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTESITSTDLIKEQIRVANGEG
LSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPPAGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQ
KMRAALEEMVINGIKTNIPLHQEILNNEDFIKGGTNIHFLEKFLEQKNKAK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=50.3401360544218, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=50.3401360544218, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=50.3401360544218, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=448, Percent_Identity=48.4375, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=48.2142857142857, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=48.2142857142857, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=48.2142857142857, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=31.0810810810811, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=31.0810810810811, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=31.0810810810811, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=31.0810810810811, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=31.0810810810811, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=30.5182341650672, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=67.7060133630289, Blast_Score=607, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.5113122171946, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=45.8049886621315, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=461, Percent_Identity=43.6008676789588, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI133931226, Length=500, Percent_Identity=30.2, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=520, Percent_Identity=28.4615384615385, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=520, Percent_Identity=28.8461538461538, Blast_Score=197, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6319695, Length=463, Percent_Identity=44.4924406047516, Blast_Score=349, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=463, Percent_Identity=45.5723542116631, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=41.1633109619687, Blast_Score=336, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=529, Percent_Identity=29.6786389413989, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=494, Percent_Identity=31.5789473684211, Blast_Score=216, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=45.6179775280899, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363050, Length=463, Percent_Identity=46.8682505399568, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=463, Percent_Identity=46.8682505399568, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=463, Percent_Identity=46.8682505399568, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=463, Percent_Identity=46.8682505399568, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=463, Percent_Identity=46.8682505399568, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=463, Percent_Identity=46.8682505399568, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=463, Percent_Identity=46.8682505399568, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=463, Percent_Identity=46.8682505399568, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=463, Percent_Identity=46.8682505399568, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=463, Percent_Identity=46.8682505399568, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=44.7174447174447, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI161076409, Length=510, Percent_Identity=29.2156862745098, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI161076407, Length=510, Percent_Identity=29.2156862745098, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24586460, Length=510, Percent_Identity=29.2156862745098, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24586458, Length=510, Percent_Identity=29.2156862745098, Blast_Score=216, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50040; Mature: 50040

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCEE
LNIQAIITAAEITNADAIHPGYGFLSENAKFAKAVEESSFIFIGPRAESIEIMGDKVEAI
EEEEEEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCEEEEECCHHHHH
RYMKKAGVPCVPGSGSPLGSDEKKNLEIAEKIGYPVIIKAAGGGGGRGMSIVRKKEDLIN
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHH
AISLTKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
HHHCCCCCCEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCCH
ESITSTDLIKEQIRVANGEGLSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPP
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCEEEECCC
AGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQKMRAALEEMVINGIKTNIPL
CCCEEEECCEEEECEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
HQEILNNEDFIKGGTNIHFLEKFLEQKNKAK
HHHHCCCCCEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCEE
LNIQAIITAAEITNADAIHPGYGFLSENAKFAKAVEESSFIFIGPRAESIEIMGDKVEAI
EEEEEEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCEEEEECCHHHHH
RYMKKAGVPCVPGSGSPLGSDEKKNLEIAEKIGYPVIIKAAGGGGGRGMSIVRKKEDLIN
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHH
AISLTKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
HHHCCCCCCEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCCH
ESITSTDLIKEQIRVANGEGLSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPP
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCEEEECCC
AGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQKMRAALEEMVINGIKTNIPL
CCCEEEECCEEEECEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
HQEILNNEDFIKGGTNIHFLEKFLEQKNKAK
HHHHCCCCCEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]