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The map label for this gene is ftsI [H]

Identifier: 134302410

GI number: 134302410

Start: 1451235

End: 1452929

Strand: Reverse

Name: ftsI [H]

Synonym: FTW_1546

Alternate gene names: 134302410

Gene position: 1452929-1451235 (Counterclockwise)

Preceding gene: 134302411

Following gene: 134302409

Centisome position: 76.53

GC content: 35.34

Gene sequence:

>1695_bases
ATGAGTAGTTATCGACCAAAACTCCGGCACTTTGTTGTAATTATTTTACTGTTGCTAAGTTTTATTGTTTTATTTATAAA
GCTTATTTATATGGAAACTATCCAATATCCTAAGCTTAAGCAAGAAGGCGATAATCGTAGTGATAGAAGTATAGATATAA
AAGCATACAGAGGTATAATCCTCGATAGAAACGGTAATCCTTTGGCGATAAGTACACCTGTTGATACAATTTGGGTTGAT
CCTTTTTATATTAGCGCGGATAGTCCTGAATTAAATAAAGTCATGGATATTTTAAATCTACCTGAAAAAACTAGAGAAAA
GATAAAAAGTCAAGTTAAGGTTAGAGAAGGAAGAAGTGGTTTTGTCTACATTGAGAGAAAGGTTCAACCATATTTATCAC
AAAAAGTTAAAGACCTTGATATTACCGGTATTCATGTGATACGAGAGTTTAAACGCTATTATCCAATGGCTGAGGTAGCT
TCTCATATTGTAGGTTTTACTAATGTTGATGGTAAAGGGCAAGAGGGTTTAGAACTTGAGTTTAATAAGTTTTTAAGTGG
TCAAGATGGTTATTTTGAATATAAAAAAGATCTTCATGGTGGGGTTGCTTCTAAGATTGAGGATAAATATGTTGAGCCTA
AGAATGGTCGTAATCTGCAGATAAGTATTGACTCTAGATTGCAATATATTGCGTATAAATATCTCAAAGAAGGGGTTATT
AGGACTAATTCTGAAGCAGGTTCTGTGATAGTTGAAGATATTCATATTGGTGAGATATTAGCAATGGCAAATTACCCTTC
GTATAATCCTAACAGCATGGCTGATGCCTATCCTGATAGGAGAAGAAATAGAGCTATTACAGATGTCTATGAGTTAGGTT
CGGTAATGAAAACTTTTGCAGCAGCGACAGCTCTAACTTATGGTGATAATGTAACTTCAGATGAGCCTGTAGTTGATACT
CACCCTGGATTCTATCGTATCGGTAAAAACACCGTAAGAGATGAACGAGATTATGGTGATATTAATCTAAGACATATCTT
AATGAAGTCTAGTAACGTTGGTGTCTCGAAGATGATTTTAGGTTTGACAGAGCCAAGTATATTAGAGTCTTCATTAAGAA
ATTTTGGTTTTGGTAGTAAGACTGGAATAAAACTACCTGGTGAAAGAGATGGTTATGTTCCAACTAAAGATAAGTGGGGT
GATTTCCAACTAGCGACATTATCTTTTGGTTATGGTATGAATGCTACTGATTTGCAGCTAATAGCTGGTGTATCCGCAAT
TGCTAATAATGGTCAATATATCAAGCCAACTATCCTAAAAAGAAGACCTGGAGAAGAGATTGAAACAAGACCTATCATAT
CTGAGAAGAATTCAAAAGAAATGATAAGTATGATGCAGTCTGTTGTTGAAGACCTGGGAGGAACTGGTTCTAAAGCACAA
ATTCCTCTTTATCATGTTGCTGGCAAAACAGGTACAGCTAGAATGCTTTCTGGTGGAAATTATGGAGCAAAATATTTGGC
AAGTTTCGTTGGTATTGTTCCAGCAACTGATCCTAAACTAGCTATAGTTGTGACAATCAAAGATCCTAAAGGAGATCAAT
ATGGTGGCGGTTCTGTAGCCGCGCCAGTTTTTGCTGATGTTGCATTAAATAGCTTGCAAATACTAGGTGTTAAGCTAGAT
AAGATTGAAAATTAA

Upstream 100 bases:

>100_bases
ACTCCTACAGCTGTGGAGAAGTTTGCTCAAAAAGAAAAAATGACCTTGCCAACACGTAAAACAATAGGCTTTTTGAATGA
GCAAAAAGAGGAGTTAAATA

Downstream 100 bases:

>100_bases
ACTCTTTGTTTTTTTATTGTTATAGTATATAATCATCTATTGGTAAACTGTTCCTTTGTGCGGTTTGCTCAATGTTAATT
TAATCAAGACAAATGGAGTA

Product: putative peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSSYRPKLRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGIILDRNGNPLAISTPVDTIWVD
PFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSGFVYIERKVQPYLSQKVKDLDITGIHVIREFKRYYPMAEVA
SHIVGFTNVDGKGQEGLELEFNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFAAATALTYGDNVTSDEPVVDT
HPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMILGLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWG
DFQLATLSFGYGMNATDLQLIAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVAAPVFADVALNSLQILGVKLD
KIEN

Sequences:

>Translated_564_residues
MSSYRPKLRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGIILDRNGNPLAISTPVDTIWVD
PFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSGFVYIERKVQPYLSQKVKDLDITGIHVIREFKRYYPMAEVA
SHIVGFTNVDGKGQEGLELEFNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFAAATALTYGDNVTSDEPVVDT
HPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMILGLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWG
DFQLATLSFGYGMNATDLQLIAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVAAPVFADVALNSLQILGVKLD
KIEN
>Mature_563_residues
SSYRPKLRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGIILDRNGNPLAISTPVDTIWVDP
FYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSGFVYIERKVQPYLSQKVKDLDITGIHVIREFKRYYPMAEVAS
HIVGFTNVDGKGQEGLELEFNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVIR
TNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFAAATALTYGDNVTSDEPVVDTH
PGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMILGLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWGD
FQLATLSFGYGMNATDLQLIAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQI
PLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVAAPVFADVALNSLQILGVKLDK
IEN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=565, Percent_Identity=38.0530973451327, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1786854, Length=594, Percent_Identity=24.5791245791246, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 62687; Mature: 62556

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYRPKLRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEEEEEEE
LDRNGNPLAISTPVDTIWVDPFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSG
EECCCCEEEEECCCCEEEECCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FVYIERKVQPYLSQKVKDLDITGIHVIREFKRYYPMAEVASHIVGFTNVDGKGQEGLELE
EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEE
FNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
HHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCE
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFA
ECCCCCCCEEEEEECHHHEEEECCCCCCCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHH
AATALTYGDNVTSDEPVVDTHPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMIL
HHHHHCCCCCCCCCCCCCCCCCCEEECCCCHHCCCCCCCCCEEEEEEEECCCCCHHHHHE
GLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWGDFQLATLSFGYGMNATDLQL
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHH
IAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
HHHHHHHHCCCCEECCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVA
EEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCH
APVFADVALNSLQILGVKLDKIEN
HHHHHHHHHCCEEEEEEEHHCCCC
>Mature Secondary Structure 
SSYRPKLRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEEEEEEE
LDRNGNPLAISTPVDTIWVDPFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSG
EECCCCEEEEECCCCEEEECCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FVYIERKVQPYLSQKVKDLDITGIHVIREFKRYYPMAEVASHIVGFTNVDGKGQEGLELE
EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEE
FNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
HHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCE
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFA
ECCCCCCCEEEEEECHHHEEEECCCCCCCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHH
AATALTYGDNVTSDEPVVDTHPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMIL
HHHHHCCCCCCCCCCCCCCCCCCEEECCCCHHCCCCCCCCCEEEEEEEECCCCCHHHHHE
GLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWGDFQLATLSFGYGMNATDLQL
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHH
IAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
HHHHHHHHCCCCEECCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVA
EEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCH
APVFADVALNSLQILGVKLDKIEN
HHHHHHHHHCCEEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]