Click here to switch to the map view.

The map label for this gene is ubiA

Identifier: 134302246

GI number: 134302246

Start: 1252021

End: 1252890

Strand: Direct

Name: ubiA

Synonym: FTW_1328

Alternate gene names: 134302246

Gene position: 1252021-1252890 (Clockwise)

Preceding gene: 134302245

Following gene: 134302247

Centisome position: 65.95

GC content: 28.62

Gene sequence:

>870_bases
ATGAATAAACAACAACTAAAAGCATATTTCATGCTAATGCGACTACATCGCCCTATTCCGATATTACTAATCTTGTGGCC
AACACTTACAGCATTAGTCTTAGCAAGTCATGGACTACCAGATATTAGCTATCTAGTTATTTTCACTATCGGTGTAGTAG
TAATGCGTACTGTAGGTTGTATTATCAATGATATTGCTGATGTCGATTTTGACAAACATGTAGCTCGCACAAATACTCGA
CCTTTAACAAGTGGACAATTAAGTATTAAAAATGCTATTTGGCTTTGTATTTCTCTTACATTAGTTGCATTTATATGTGT
ATTATTTTTGAACTTATACACGATTTTATTATCATTTGTAGCACTATTCTTAGCAATACTATATCCGTTTTGTAAACGAT
TTTTTGCGATACCTCAACTAATACTCGGATTAGCATTTAATTTTGGTATTTTTATGGCTTTTTCTGCAATACAAAACCAA
ATACCAGTCGAAGCGTGGATATTTTATATAGCTACGATATGCTGGACAATAGCTTATGATACTATCTATGCACTAGCTGA
TCGAGAATTTGATTTAGAGATTGGTATAAAGTCATCTGCTGTTTTATTTGGTAATAAAGTATTTAGATATATCTTATTAT
TTAATTTCTTATCTTTACTTCTTTTAATAATCCTTGGTATTTATTGTGATTTTAATAGTTTTTTTTATTTAGGTGTTGTT
ATTTGTAGTTTATTTTTCGTTAGAAATTATTTTTTATATAAAAAATTAGGCATCACTAACTGTATAAATGCTTTTTCTGC
TAATCATTGGATTGGCTTAATAATTTTTATTATAGCAGTGATACAATATATAATCAAGGAATTTTTATGA

Upstream 100 bases:

>100_bases
AAATATTCTCTCGTAGCTCAATATTTGAATATAAAGATAACTCAGAACTTAAATTTTTGATTACGGAATATTTCCTAGTT
TTACCCGAGCAATACTGACT

Downstream 100 bases:

>100_bases
TAAAAGTTTTCTATGATGGTAAATGTGGTCTTTGCACTAAAGAAATAAACCACTACAAAAAGATAGCTCCAAAGAATATT
TTTAGCTGGATTGATATAAC

Product: 4-hydroxybenzoate polyprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTR
PLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQ
IPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYIIKEFL

Sequences:

>Translated_289_residues
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTR
PLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQ
IPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYIIKEFL
>Mature_289_residues
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTR
PLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQ
IPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYIIKEFL

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=279, Percent_Identity=34.7670250896057, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1790473, Length=283, Percent_Identity=41.3427561837456, Blast_Score=210, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17553718, Length=287, Percent_Identity=34.1463414634146, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32565247, Length=291, Percent_Identity=32.6460481099656, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17553720, Length=188, Percent_Identity=37.7659574468085, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565245, Length=144, Percent_Identity=39.5833333333333, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI32565243, Length=143, Percent_Identity=39.1608391608392, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=295, Percent_Identity=30.1694915254237, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355567, Length=285, Percent_Identity=37.1929824561403, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_FRATF (A7NA50)

Other databases:

- EMBL:   CP000803
- RefSeq:   YP_001427809.1
- STRING:   A7NA50
- GeneID:   5524532
- GenomeReviews:   CP000803_GR
- KEGG:   fta:FTA_0376
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12847
- BioCyc:   FTUL458234:FTA_0376-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33090; Mature: 33090

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x403a38f0)-; HASH(0xee6d5e0)-; HASH(0xe68b190)-; HASH(0xeb51408)-; HASH(0xe595290)-; HASH(0xdf6dee8)-; HASH(0xee52618)-; HASH(0xd696e28)-; HASH(0xe1722fc)-;

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGC
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IINDIADVDFDKHVARTNTRPLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFV
HHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQIPVEAWIFYIATICWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
HHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYIIKEFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGC
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IINDIADVDFDKHVARTNTRPLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFV
HHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQIPVEAWIFYIATICWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
HHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYIIKEFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA