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The map label for this gene is adk

Identifier: 134302149

GI number: 134302149

Start: 1134415

End: 1135071

Strand: Direct

Name: adk

Synonym: FTW_1200

Alternate gene names: 134302149

Gene position: 1134415-1135071 (Clockwise)

Preceding gene: 134302140

Following gene: 134302156

Centisome position: 59.75

GC content: 33.79

Gene sequence:

>657_bases
ATGCGTATAATACTTTTAGGAGCACCTGGAGCCGGTAAAGGAACTCAAGCAAAGATAATTGAACAAAAATATAATATCGC
TCATATTTCTACTGGAGATATGATAAGAGAAACTATAAAATCAGGTTCGGCACTTGGTCAAGAATTAAAAAAAGTTCTTG
ATGCTGGAGAGTTAGTTTCAGATGAGTTTATTATCAAAATTGTCAAAGATAGAATTTCAAAAAATGATTGTAACAATGGC
TTTTTATTAGATGGTGTCCCTAGAACTATTCCACAAGCACAAGAATTAGACAAGTTAGGTGTAAATATTGACTATATAGT
TGAGGTAGATGTGGCTGATAACCTTCTTATAGAGAGAATTACAGGTAGGAGAATACATCCAGCATCTGGTAGAACTTATC
ACACTAAATTTAACCCACCTAAAGTAGCCGACAAAGATGATGTAACCGGTGAACCACTAATAACTCGTACAGATGACAAT
GAAGACACAGTTAAACAAAGACTATCTGTATACCATGCTCAAACCGCCAAGTTAATCGATTTTTACAGAAATTTCTCATC
AACGAACACTAAAATACCAAAATATATTAAGATAAACGGCGATCAAGCTGTTGAGAAAGTGTCTCAGGATATTTTTGATC
AGCTTAATAAAAGATAA

Upstream 100 bases:

>100_bases
AAAATTAGGTACTCTATTTCTAGATATATAAGTTTGTTTATTTTATAATTAAATCCACATTAAGTAAACTGTAGTTTTAA
AACGTTAAGGTTAATTAACA

Downstream 100 bases:

>100_bases
TTCTTAAAAAAACAATCCTCTTTATGAGTAATTACTACTTAGCTTAAATATTAAAGAGTTGGTAAGGATTTGGAAATAAA
TATTTTAGAAGTAATTATCA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSALGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNG
FLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDN
EDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR

Sequences:

>Translated_218_residues
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSALGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNG
FLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDN
EDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
>Mature_218_residues
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSALGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNG
FLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDN
EDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=187, Percent_Identity=52.9411764705882, Blast_Score=218, Evalue=2e-57,
Organism=Homo sapiens, GI4502013, Length=187, Percent_Identity=52.9411764705882, Blast_Score=218, Evalue=2e-57,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=39.9014778325123, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI310110345, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832003, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI8051579, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832001, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI22749187, Length=222, Percent_Identity=28.8288288288288, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=29.7674418604651, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI28144897, Length=215, Percent_Identity=26.046511627907, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI28144899, Length=215, Percent_Identity=26.046511627907, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI237858799, Length=149, Percent_Identity=25.503355704698, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=58.0188679245283, Blast_Score=261, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=51.063829787234, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=34.5945945945946, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=29.9539170506912, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=24.4131455399061, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=222, Percent_Identity=48.1981981981982, Blast_Score=226, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=40.5405405405405, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=28.2407407407407, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=55.1912568306011, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=40.1098901098901, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=40.1098901098901, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=29.3838862559242, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=29.3838862559242, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_FRAT1 (Q14H66)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667260.1
- ProteinModelPortal:   Q14H66
- SMR:   Q14H66
- STRING:   Q14H66
- GeneID:   4199758
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF1161
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q14H66
- ProtClustDB:   PRK00279
- BioCyc:   FTUL393115:FTF1161-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24362; Mature: 24362

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSALGQELKKVLDAGELVS
CEEEEEECCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DEFIIKIVKDRISKNDCNNGFLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERI
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHH
TGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDNEDTVKQRLSVYHAQTAKLID
CCCEECCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
FYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
HHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSALGQELKKVLDAGELVS
CEEEEEECCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DEFIIKIVKDRISKNDCNNGFLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERI
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHH
TGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDNEDTVKQRLSVYHAQTAKLID
CCCEECCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
FYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
HHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA