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The map label for this gene is pth [H]

Identifier: 134302016

GI number: 134302016

Start: 991855

End: 992430

Strand: Direct

Name: pth [H]

Synonym: FTW_1048

Alternate gene names: 134302016

Gene position: 991855-992430 (Clockwise)

Preceding gene: 134302015

Following gene: 134302017

Centisome position: 52.24

GC content: 32.47

Gene sequence:

>576_bases
ATGCCTAAAATAAAAATGATTGTTGGCCTAGGTAATATAGGCAAAGAATATCAAGATACGCGCCATAATGTTGGTGAATG
GTTTATTGCTAAAATAGCTCAAGATAACAATCAAAGCTTTAGTTCTAATCCTAAGCTTAATTGTAATCTAGCTAAAGTTA
GCATTGATTATAATAATGTAGTACTAGTATTTCCTACAACTTATATGAATAACAGCGGTTTAGCTGTTAGCAAAGTCGCT
AATTTTTATAAAATCGCGCCAGCAGAGATACTTGTAGTACATGATGAGCTAGATATAGATTCTGGAGAAATACGTCTAAA
AAAAGGCGGAGGTCATGGTGGTCATAACGGTCTAAGAAGTATTAACCAACACTTAGGCACTAATGACTACCTACGCCTTA
GAATTGGTATTGGTCATCCTGGTCATAAATCAAAAGTAGCTAACTATGTATTATCAAATCCATCTATAGCTCAGAAAAAA
GATATAGATAGTGCTATTGATAATGGTATCTGTTTTTTAGATGATATAATAAATTACAAATTAGAACCTGTAATGCAGAA
GCTACATACAAAATAA

Upstream 100 bases:

>100_bases
TATACCCAATCGCAAAAAAATGCTAAACCAAACAGTAAAATTGTTAGAGAGGTAACTAAAATACTGCTAAACAGACTACA
ATTAAACAATACTACGAAAA

Downstream 100 bases:

>100_bases
TATATAAGGAATAAAATAATGGGATTTAAATGTGGTATAGTAGGTTTACCAAATGTTGGCAAATCAACTCTTTTTAATGC
TCTTACAGAAGCAGGAATTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MPKIKMIVGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNPKLNCNLAKVSIDYNNVVLVFPTTYMNNSGLAVSKVA
NFYKIAPAEILVVHDELDIDSGEIRLKKGGGHGGHNGLRSINQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKK
DIDSAIDNGICFLDDIINYKLEPVMQKLHTK

Sequences:

>Translated_191_residues
MPKIKMIVGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNPKLNCNLAKVSIDYNNVVLVFPTTYMNNSGLAVSKVA
NFYKIAPAEILVVHDELDIDSGEIRLKKGGGHGGHNGLRSINQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKK
DIDSAIDNGICFLDDIINYKLEPVMQKLHTK
>Mature_190_residues
PKIKMIVGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNPKLNCNLAKVSIDYNNVVLVFPTTYMNNSGLAVSKVAN
FYKIAPAEILVVHDELDIDSGEIRLKKGGGHGGHNGLRSINQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKKD
IDSAIDNGICFLDDIINYKLEPVMQKLHTK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=180, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=45.2127659574468, Blast_Score=140, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321983, Length=156, Percent_Identity=32.0512820512821, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21123; Mature: 20992

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIKMIVGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNPKLNCNLAKVSIDYNNV
CCCEEEEEEECCCCHHHHHHHHCHHHHHHHEECCCCCCCCCCCCCEEEEEEEEEECCCCE
VLVFPTTYMNNSGLAVSKVANFYKIAPAEILVVHDELDIDSGEIRLKKGGGHGGHNGLRS
EEEEECEEECCCCEEHHHHHHHHEECCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHH
INQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKKDIDSAIDNGICFLDDIINYK
HHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEHHHHCCC
LEPVMQKLHTK
HHHHHHHHCCC
>Mature Secondary Structure 
PKIKMIVGLGNIGKEYQDTRHNVGEWFIAKIAQDNNQSFSSNPKLNCNLAKVSIDYNNV
CCEEEEEEECCCCHHHHHHHHCHHHHHHHEECCCCCCCCCCCCCEEEEEEEEEECCCCE
VLVFPTTYMNNSGLAVSKVANFYKIAPAEILVVHDELDIDSGEIRLKKGGGHGGHNGLRS
EEEEECEEECCCCEEHHHHHHHHEECCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHH
INQHLGTNDYLRLRIGIGHPGHKSKVANYVLSNPSIAQKKDIDSAIDNGICFLDDIINYK
HHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEHHHHCCC
LEPVMQKLHTK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA