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The map label for this gene is nrdB [H]

Identifier: 134301991

GI number: 134301991

Start: 959695

End: 960927

Strand: Direct

Name: nrdB [H]

Synonym: FTW_1010

Alternate gene names: 134301991

Gene position: 959695-960927 (Clockwise)

Preceding gene: 134301990

Following gene: 134301993

Centisome position: 50.55

GC content: 35.28

Gene sequence:

>1233_bases
ATGGTCAAAGTAAGAATATATACTAAAACAAATTGTCCTTTTTGTGATCTTGCAAAAAGTTGGTTTGGTGCTAATGATAT
CCCTTTTACGCAGATATCACTTGATGATGATGTCAAAAGAGCAGAATTCTATGCTGAAGTAAATAAGAATATTCTTCTTG
TAGAAGAACACATCCGAACCGTACCACAGATATTTGTTGGCGATGTACATATTGGCGGTTATGATAATCTTATGGCTAGA
GCTGGTGAGGTGATTGCACGTGTTAAAGGTTCATCGTTAACTACTTTCTCAAAAACATACAAGCCTTTTAACTATCCTTG
GGCTGTTGATCTTACTGTAAAACATGAAAAAGCTCACTGGATAGAAGATGAAATTGATCTTTCTGAAGATGTCACAGATT
GGAAAAATGGTAAAATAACCAAAGTTGAGAAAGAATATATTACTAATATTCTGAGGCTTTTTACTCAGTCTGATGTTGCA
GTTGGTCAGAACTATTATGATCAATTTATTCCTTTATTCAAAAATAATGAAATAAGGAATATGCTTGGTTCATTTGCAGC
TCGTGAAGGTATTCATCAAAGAGCATATGCGCTGCTAAATGACACTCTAGGCTTACCTGATTCAGAATATCATGCCTTCT
TAGAATATAAAGCAATGACTGATAAAATTGATTTTATGATGGATGCAGACCCTACTACGCGTCGTGGTTTAGGATTATGT
CTTGCTAAGACGGTATTTAATGAAGGTGTAGCTTTATTTGCATCTTTTGCAATGCTGCTTAACTTTCAACGCTTTGGTAA
AATGAAAGGCATGGGTAAAGTAGTAGAATGGTCAATTCGTGATGAATCTATGCATGTCGAAGGTAATGCAGCACTATTTA
GAATTTACTGTCAAGAAAATCCTTACATAGTTGATAATGAATTCAAAAAAGAGATCTATCTAATGGCTAGTAAAGCTGTA
GAACTAGAAGATAGGTTTATTGAACTAGCTTACGAACTTGGTACTATCGAAGGACTCAAAGCTGATGAAGTTAAACAATA
TATCCGTCATATCACTGATAGACGCCTAAATCAACTTGGACTAAAAGAAATCTATAATATTGAGAAAAACCCACTAACAT
GGTTAGAGTGGATACTAAATGGTGCAGATCACACTAACTTCTTCGAAAACCGTGTCACCGAATATGAAGTTGCTGGTTTA
ACAGGTAGTTGGGACGAGGCTTATAGCGCCTAA

Upstream 100 bases:

>100_bases
TTCAACTGTGCCACAAATATTCATAGATGATGAACATATAGGTGGCTTTACAGAGCTTAAGGCTAATGCTGATAAAATTT
TAAACAAAAAATAGGTTAAT

Downstream 100 bases:

>100_bases
TTTTAGTTAATAGATTCTAATTCTTCGAGTGCTACAAACCAATCTAATTCAATTTCTTCAATTTTTCCTTTTAAATTAGA
GTGCTCAAGCAAAGTCTGTT

Product: bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVKVRIYTKTNCPFCDLAKSWFGANDIPFTQISLDDDVKRAEFYAEVNKNILLVEEHIRTVPQIFVGDVHIGGYDNLMAR
AGEVIARVKGSSLTTFSKTYKPFNYPWAVDLTVKHEKAHWIEDEIDLSEDVTDWKNGKITKVEKEYITNILRLFTQSDVA
VGQNYYDQFIPLFKNNEIRNMLGSFAAREGIHQRAYALLNDTLGLPDSEYHAFLEYKAMTDKIDFMMDADPTTRRGLGLC
LAKTVFNEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQENPYIVDNEFKKEIYLMASKAV
ELEDRFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLGLKEIYNIEKNPLTWLEWILNGADHTNFFENRVTEYEVAGL
TGSWDEAYSA

Sequences:

>Translated_410_residues
MVKVRIYTKTNCPFCDLAKSWFGANDIPFTQISLDDDVKRAEFYAEVNKNILLVEEHIRTVPQIFVGDVHIGGYDNLMAR
AGEVIARVKGSSLTTFSKTYKPFNYPWAVDLTVKHEKAHWIEDEIDLSEDVTDWKNGKITKVEKEYITNILRLFTQSDVA
VGQNYYDQFIPLFKNNEIRNMLGSFAAREGIHQRAYALLNDTLGLPDSEYHAFLEYKAMTDKIDFMMDADPTTRRGLGLC
LAKTVFNEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQENPYIVDNEFKKEIYLMASKAV
ELEDRFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLGLKEIYNIEKNPLTWLEWILNGADHTNFFENRVTEYEVAGL
TGSWDEAYSA
>Mature_410_residues
MVKVRIYTKTNCPFCDLAKSWFGANDIPFTQISLDDDVKRAEFYAEVNKNILLVEEHIRTVPQIFVGDVHIGGYDNLMAR
AGEVIARVKGSSLTTFSKTYKPFNYPWAVDLTVKHEKAHWIEDEIDLSEDVTDWKNGKITKVEKEYITNILRLFTQSDVA
VGQNYYDQFIPLFKNNEIRNMLGSFAAREGIHQRAYALLNDTLGLPDSEYHAFLEYKAMTDKIDFMMDADPTTRRGLGLC
LAKTVFNEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQENPYIVDNEFKKEIYLMASKAV
ELEDRFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLGLKEIYNIEKNPLTWLEWILNGADHTNFFENRVTEYEVAGL
TGSWDEAYSA

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=301, Percent_Identity=29.2358803986711, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI42544136, Length=301, Percent_Identity=29.2358803986711, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI260064013, Length=299, Percent_Identity=28.4280936454849, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4557845, Length=299, Percent_Identity=28.7625418060201, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI289177076, Length=289, Percent_Identity=30.1038062283737, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788567, Length=324, Percent_Identity=22.8395061728395, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551968, Length=288, Percent_Identity=28.4722222222222, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322434, Length=298, Percent_Identity=30.8724832214765, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18079279, Length=307, Percent_Identity=28.9902280130293, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 47281; Mature: 47281

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVRIYTKTNCPFCDLAKSWFGANDIPFTQISLDDDVKRAEFYAEVNKNILLVEEHIRT
CEEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEHHHHHH
VPQIFVGDVHIGGYDNLMARAGEVIARVKGSSLTTFSKTYKPFNYPWAVDLTVKHEKAHW
CHHHEECCEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCEEEEEEEECCCCCC
IEDEIDLSEDVTDWKNGKITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRN
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCHHHCCHHHHHHCCHHCCCHHHH
MLGSFAAREGIHQRAYALLNDTLGLPDSEYHAFLEYKAMTDKIDFMMDADPTTRRGLGLC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEHHHHHCCEEEEECCCCCCHHHHHHH
LAKTVFNEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQEN
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEEEEECCC
PYIVDNEFKKEIYLMASKAVELEDRFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLG
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LKEIYNIEKNPLTWLEWILNGADHTNFFENRVTEYEVAGLTGSWDEAYSA
HHHHHCCCCCCHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCCHHHCCC
>Mature Secondary Structure
MVKVRIYTKTNCPFCDLAKSWFGANDIPFTQISLDDDVKRAEFYAEVNKNILLVEEHIRT
CEEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEHHHHHH
VPQIFVGDVHIGGYDNLMARAGEVIARVKGSSLTTFSKTYKPFNYPWAVDLTVKHEKAHW
CHHHEECCEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCEEEEEEEECCCCCC
IEDEIDLSEDVTDWKNGKITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRN
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCHHHCCHHHHHHCCHHCCCHHHH
MLGSFAAREGIHQRAYALLNDTLGLPDSEYHAFLEYKAMTDKIDFMMDADPTTRRGLGLC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEHHHHHCCEEEEECCCCCCHHHHHHH
LAKTVFNEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQEN
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEEEEECCC
PYIVDNEFKKEIYLMASKAVELEDRFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLG
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LKEIYNIEKNPLTWLEWILNGADHTNFFENRVTEYEVAGLTGSWDEAYSA
HHHHHCCCCCCHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]