Click here to switch to the map view.

The map label for this gene is nrdA [H]

Identifier: 134301989

GI number: 134301989

Start: 957652

End: 959424

Strand: Direct

Name: nrdA [H]

Synonym: FTW_1008

Alternate gene names: 134301989

Gene position: 957652-959424 (Clockwise)

Preceding gene: 134301988

Following gene: 134301990

Centisome position: 50.44

GC content: 36.04

Gene sequence:

>1773_bases
ATGTCTAATCAAAGCTATCTTGGCATTAATATTGATTTATCTAGAGATCGTGAGCTTTCAGAACAAGCTCAACAACTACT
GACAAACTATTATTGCTTACAAAATGAACCCTCTCCTCAATATGCTTTTGCACGAGCTGCTGTTGCTTATTCTTTTGGGG
ATATGAACCTAGCTCAGCGCATTTATGCTGCTGCTGCTAAAGGTTGGTTTATGTTTGCTTCACCTGTGCTTTCTAATGCA
CCACTTCCAGGTGTAAAAGTAAAATCTTTACCTATTAGTTGTTTTTTATCTTATGTGCCAGATTCATTAGAAGGTCTTAT
CGAGCATTCATCAGAACTTAGATGGTTATCAGTAAAAGGTGGAGGTGTTGGAGGACACTGGTCTAGTGTTCGTGCGGTAT
CTGATAAAGCTCCAGGACCTATCCCATTTATGCATACAGTTGATGCTGATATGGTTGCCTATAGACAAGGTAAAACTCGT
AAAGGTTCATATGCTGCATATATGGACATATCACACCCTGATATAATTGAATTTTTAGGTATCCGTGTGCCAACAGGTGA
TGTAAATAGAAAATGTCTAAACCTACATCATGCTGTAAATCTGACTGATGATTTTATGCAAGCAGTTGCAAATGACCAAG
ACTGGAAACTTATTGATCCAGATGACAAAACAGTAAGAGATGTTATCAAGGCTCGCAAAATTTGGGAAACCATATTAGAA
ACTCGTTACCGTACAGGTGAACCATACTTAAACTTTATTGACACAGCTAATAGAGCTTTACCAAAATCTCAAAAAGACCT
GGGCTTGACAATCAAAGGTTCAAATCTATGCAATGAGATTCATTTAGTTACAGATGAAAAACGTACAGCAGTATGCTGTT
TATCTTCTGTAAATTTAGAAAGATACGATGAATGGAAAGATACCTCACTTATCAAAGATTTAATTAGATTTTTAGATAAC
GTATTACAGTTTTTCATAGATCATGCTGGTGATGAAATCTCTAAGGCTAGATATAGTGCTTCACGTGAGAGAAGTCTAGG
TCTAGGAGCTATGGGGTTTCATTCTTATTTACAGCTTCATCGTGTACCTTTTGAGTCTCAAAGAGCAAAAGAAATTAATG
AAGAGATATTTAAGCGTATCAAAGAACAAGCGCTAGAAGAAACTCTAATACTTGGTGCTGAAAAAGGCGAAGCGCCAGAC
ATGGCAGGAACAGGACGTAGAAATGCTCACTTACTTGCTATAGCTCCTAATGCCAATAGTTCGCTTATCTTGAATACTTC
TCCAAGTATTGAACCTTGGAAAGCAAATGCTTTTACCTCTAGAACAAGAGTTGGTTCACATCTTAATAAGAACAAATATC
TAGAACAAGAACTAGAAAAAATTGGTAAAAATACTGAAGAAGTTTGGTCAGATATTATTACTAATGGTGGATCAGTTCAA
CAACTAGATTTTCTCAGTAAAGAATTAAAAGAAGTATTTAAAACTGCTATTGAAATGGATCAAGATTGGTTAGTCTATCT
AGGTGGTGAACGCCAAAAATATCTATGCCAAGGACAATCATTAAATGTATTTTTCCCAGCGGGAGCATCGCGTGGATATC
TTCACAAAGTACACTTTAATGCTTGGAAATATGGTTGTAAAGGTTTATATTATCTAAGAACAGAGACTTCAAATAGAGCT
GAGAATATTTCTAAAAAAGTCGAGAAGAAAAGACTTGTAGAGTTCTCAGAAATTAAGCAGTCTGAAAATGAGTGTATCGC
TTGTGAAGGATAA

Upstream 100 bases:

>100_bases
AAAAAATTGATAAAATTTTACTAAGAAATAAATAATTATACTAATCTGGTATAGTATTACTATCAAGTTAGTATATAAGC
ATTTTAAATAGGGTTTTATC

Downstream 100 bases:

>100_bases
AATATGAAAGTAAAAATATATACTAGAAATGGTTGTCAATATTGTGTTTGGGCAAAACAATGGTTCGAAGAAAATAATAT
AGCTTTTGATGAAACTATAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MSNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQRIYAAAAKGWFMFASPVLSNA
PLPGVKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKGGGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTR
KGSYAAYMDISHPDIIEFLGIRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLERYDEWKDTSLIKDLIRFLDN
VLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLHRVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPD
MAGTGRRNAHLLAIAPNANSSLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
QLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFNAWKYGCKGLYYLRTETSNRA
ENISKKVEKKRLVEFSEIKQSENECIACEG

Sequences:

>Translated_590_residues
MSNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQRIYAAAAKGWFMFASPVLSNA
PLPGVKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKGGGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTR
KGSYAAYMDISHPDIIEFLGIRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLERYDEWKDTSLIKDLIRFLDN
VLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLHRVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPD
MAGTGRRNAHLLAIAPNANSSLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
QLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFNAWKYGCKGLYYLRTETSNRA
ENISKKVEKKRLVEFSEIKQSENECIACEG
>Mature_589_residues
SNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQRIYAAAAKGWFMFASPVLSNAP
LPGVKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKGGGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTRK
GSYAAYMDISHPDIIEFLGIRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILET
RYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLERYDEWKDTSLIKDLIRFLDNV
LQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLHRVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPDM
AGTGRRNAHLLAIAPNANSSLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQQ
LDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFNAWKYGCKGLYYLRTETSNRAE
NISKKVEKKRLVEFSEIKQSENECIACEG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=605, Percent_Identity=30.9090909090909, Blast_Score=245, Evalue=7e-65,
Organism=Escherichia coli, GI1789030, Length=609, Percent_Identity=22.6600985221675, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI2367133, Length=648, Percent_Identity=22.5308641975309, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555242, Length=626, Percent_Identity=29.5527156549521, Blast_Score=237, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6322123, Length=640, Percent_Identity=28.28125, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6320914, Length=635, Percent_Identity=29.2913385826772, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17352481, Length=601, Percent_Identity=27.6206322795341, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 66549; Mature: 66418

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQR
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHH
IYAAAAKGWFMFASPVLSNAPLPGVKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKG
HHHHHHCCHHEEECHHHCCCCCCCCEEECCHHHHHHHHCCHHHHHHHHCCCCEEEEEEEC
GGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTRKGSYAAYMDISHPDIIEFLG
CCCCCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHC
IRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLE
HHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEEHHCCHH
RYDEWKDTSLIKDLIRFLDNVLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPDMAGTGRRNAHLLAIAPNANS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCCCC
SLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
EEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
QLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFN
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEEECCCCCCCCEEEEEEC
AWKYGCKGLYYLRTETSNRAENISKKVEKKRLVEFSEIKQSENECIACEG
HHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
SNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQR
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHH
IYAAAAKGWFMFASPVLSNAPLPGVKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKG
HHHHHHCCHHEEECHHHCCCCCCCCEEECCHHHHHHHHCCHHHHHHHHCCCCEEEEEEEC
GGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTRKGSYAAYMDISHPDIIEFLG
CCCCCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHC
IRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLE
HHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEEHHCCHH
RYDEWKDTSLIKDLIRFLDNVLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPDMAGTGRRNAHLLAIAPNANS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCCCC
SLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
EEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
QLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFN
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEEECCCCCCCCEEEEEEC
AWKYGCKGLYYLRTETSNRAENISKKVEKKRLVEFSEIKQSENECIACEG
HHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]