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The map label for this gene is ttcA1

Identifier: 134301940

GI number: 134301940

Start: 915041

End: 915844

Strand: Direct

Name: ttcA1

Synonym: FTW_0951

Alternate gene names: 134301940

Gene position: 915041-915844 (Clockwise)

Preceding gene: 134301939

Following gene: 134301941

Centisome position: 48.2

GC content: 31.59

Gene sequence:

>804_bases
ATGACTAATAATACTGATAAACAAACTTTAAAGAAACTTGAAAGACAGATTTTAAGAAAAACTGCTCAAGCAATCAATCA
ATATAATATGATTGAAGATGGCGATAAAATTATGGTATGCCTATCTGGAGGCAAAGATTCTTATTGTTTACTTGAGATGT
TGTTATTACTCCAAAAAAAAGCTCCAATAAGCTTTGAAATCATCGCAGTAAATCTCGATCAGAAACAACCAGGCTTTCCT
GAAGAAGTATTACCTAACTATCTTAAAAATAAAGGGGTAGAATTCCATATCATTGAACGTGATACTTATAGCATAGTAAA
ACGTGTAATTCCTGAAGGGAAAACTACCTGTGGTTTATGCTCCCGTATGCGTCGTGGTATCTTATATGATTTTGCTGAAG
AAAATAATGTAACTAAGGTAGCATTAGGCCATCATCGAGATGACATCATTGAAACATTCTTCTTGAATCTTTTTTATAAT
GGCTCAATCAAAGCTATGCCAGCTAAACTACTTAGTGATGATAAACGCAATATCGTAATCCGCCCTCTCGCTTTTGTAAG
CGAAAAAGAAACTTTAGAATACTCTCAATTAAAAGAGTTTCCTATAATTCCTTGTAACCTATGTGGTTCACAAGATAATT
TGCAAAGAGTGTTTATAAAAGATATGCTTAATAGATGGGAACAAAATAATCCTGAAAGAAAAAATGTAATATTCAAAGCT
CTATCAAATATTTCTCCATCACAGATGTTAGATAAAGAGCTTTTTGATTTTATAAATATCTCAAAAGATGATATACAAAG
ATAG

Upstream 100 bases:

>100_bases
GTTATCACTAGAGCAAAAGCCAAATTGGCCTGTTATAATGCTAAAACAGGTAGATTACAAAAAATTCCACCACAATTAAA
ACAATTGATCTTAGAAGAAA

Downstream 100 bases:

>100_bases
TTAAGGAGAAAAATGAAGTTAAAGAAAATAGTAGCAGTTATATCATGCTCATTATTAGGACTAGCTATGAGTTCATGTTC
AACAAATACAGATTCCGTAG

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFP
EEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYN
GSIKAMPAKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
LSNISPSQMLDKELFDFINISKDDIQR

Sequences:

>Translated_267_residues
MTNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFP
EEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYN
GSIKAMPAKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
LSNISPSQMLDKELFDFINISKDDIQR
>Mature_266_residues
TNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPE
EVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNG
SIKAMPAKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKAL
SNISPSQMLDKELFDFINISKDDIQR

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=256, Percent_Identity=58.984375, Blast_Score=329, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI193211090, Length=232, Percent_Identity=32.7586206896552, Blast_Score=127, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA1_FRAT1 (Q14HG9)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667157.1
- ProteinModelPortal:   Q14HG9
- STRING:   Q14HG9
- GeneID:   4200681
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF1042
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   FPHAREE
- PhylomeDB:   Q14HG9
- ProtClustDB:   PRK10696
- BioCyc:   FTUL393115:FTF1042-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 30897; Mature: 30766

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCC
APISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLC
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHH
SRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPAKLLSDDKRNIVI
HHHHHCCEEEHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEE
RPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
EHHHHHCCHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSNISPSQMLDKELFDFINISKDDIQR
HHCCCHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCC
APISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLC
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHH
SRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPAKLLSDDKRNIVI
HHHHHCCEEEHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEE
RPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
EHHHHHCCHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSNISPSQMLDKELFDFINISKDDIQR
HHCCCHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA