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The map label for this gene is folKP [H]

Identifier: 134301853

GI number: 134301853

Start: 814204

End: 815469

Strand: Reverse

Name: folKP [H]

Synonym: FTW_0836

Alternate gene names: 134301853

Gene position: 815469-814204 (Counterclockwise)

Preceding gene: 134301854

Following gene: 134301852

Centisome position: 42.95

GC content: 29.7

Gene sequence:

>1266_bases
GTGCAATATATTATAGGAATTGGAACAAATATTGGTTTTACTATCGAAAATATTCATCTTGCAATAACTGCACTAGAATC
GCAACAAAATATAAGAATCATCAGAAAAGCAAGCTTATACAGTAGTAAAGCTGTCCTTAAAGAAGACGCTCCTAAAGAAT
GGGATATTAGATTTTTAAATACAGCTGTAAAAATTAGCTCTTCACTAAAGCCTGATGAACTTTTAGTACTCTTAAAAGAC
ATAGAATTAAAAATAGGTAGAGACCTAAATGCTCCTGCATGGTCACCTCGAGTAATTGATTTAGATATTCTTGCTGCTGA
AGATCTAATTTTAGAAACAGACAAACTTACTATTCCTCATAAAGAACTAATTAATCGTAGTTTTGCGTTGGCTCCTTTAT
TAGAATTATCAAAGGGTTGGCATCACCCTAAATATGTTGAATGGGATCTTAATATAAGATTAAAAGAATTAGGTGAGATA
GTAAAACTTAAACAAACTCTTGCAAATACAATACGTATGGGTATAGTTAATCTGTCAAATCAATCTTTTTCAGATGGTAA
TTTTGATGATAATCAACGTAAATTAAACCTTGATGAGCTAATACAAAGTGGTGCTGAAATTATTGATATCGGAGCTGAAT
CGACTAAGCCTGATGCCAAGCCTATATCGATTGAAGAAGAATTTAACAAATTAGATGAATTCCTAGAATACTTTAAATCA
CAACTGGCAAATTTGATTTATAAACCATTAGTCAGTATTGACACACGCAAACTAGAGGTAATGCAAAAAATTCTCGCTAA
GCATCATGATATTATCTGGATGATAAATGATGTTGAATGTAATAATATTGAGCAAAAAGCACAGCTTATAGCTAAATATA
ATAAAAAGTATGTTATAATTCATAATTTGGGTATTACAGATAGAAATCAATATTTAGATAAAGAAAATGCTATAGATAAT
GTTTGTGATTATATTGAGCAAAAAAAGCAAATTCTTCTAAAACATGGTATAGCACAACAAAATATTTATTTTGATATTGG
CTTTGGTTTTGGTAAAAAATCAGATACCGCTAGATACTTATTAGAGAATATCATCGAGATAAAAAGAAGATTAGAATTAA
AAGCATTAGTTGGTCACTCACGTAAGCAATCAGTTTTAGGATTAGCAAAAGATAGTAATTTAGCAACTTTAGATCGAGCT
ACAAGAGAGCTTTCAAGAAAATTAGAGAAACTAGATATTGATATTATAAGAGTACACAAGATTTAA

Upstream 100 bases:

>100_bases
CAAAAAAACTATAGTGATATAACTATCAAATACTTGAAAATTAACAAAAAGCCCCCAGTTTCTCAAATAGAGTCAGCTTG
TTTTATAATTAGGAACTAGT

Downstream 100 bases:

>100_bases
TAAGGAAATATTATGCCATACAATCCATCATTAGAAGCATTATTAGACACTCCTGAAATAAGAAGAATTAAAAAGCTTGA
TTTAACACAACAGCGTGAAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase

Products: NA

Alternate protein names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; Dihydropteroate synthase; DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MQYIIGIGTNIGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD
IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI
VKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLDEFLEYFKS
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNLGITDRNQYLDKENAIDN
VCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIKRRLELKALVGHSRKQSVLGLAKDSNLATLDRA
TRELSRKLEKLDIDIIRVHKI

Sequences:

>Translated_421_residues
MQYIIGIGTNIGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD
IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI
VKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLDEFLEYFKS
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNLGITDRNQYLDKENAIDN
VCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIKRRLELKALVGHSRKQSVLGLAKDSNLATLDRA
TRELSRKLEKLDIDIIRVHKI
>Mature_421_residues
MQYIIGIGTNIGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD
IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI
VKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLDEFLEYFKS
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNLGITDRNQYLDKENAIDN
VCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIKRRLELKALVGHSRKQSVLGLAKDSNLATLDRA
TRELSRKLEKLDIDIIRVHKI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=134, Percent_Identity=35.8208955223881, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=29.0697674418605, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324073, Length=517, Percent_Identity=23.9845261121857, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000550
- InterPro:   IPR000489 [H]

Pfam domain/function: PF01288 HPPK; PF00809 Pterin_bind [H]

EC number: =2.7.6.3; =2.5.1.15 [H]

Molecular weight: Translated: 48276; Mature: 48276

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYIIGIGTNIGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLN
CCEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEHH
TAVKISSSLKPDELLVLLKDIELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPH
HHHHHCCCCCHHHHEEEEEHHHHEECCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCH
KELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEIVKLKQTLANTIRMGIVNLSN
HHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHEEEECC
QSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLDEFLEYFKS
CCCCCCCCCCCCCEECHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVII
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEE
HNLGITDRNQYLDKENAIDNVCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYL
EECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
LENIIEIKRRLELKALVGHSRKQSVLGLAKDSNLATLDRATRELSRKLEKLDIDIIRVHK
HHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
I
C
>Mature Secondary Structure
MQYIIGIGTNIGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLN
CCEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEHH
TAVKISSSLKPDELLVLLKDIELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPH
HHHHHCCCCCHHHHEEEEEHHHHEECCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCH
KELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEIVKLKQTLANTIRMGIVNLSN
HHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHEEEECC
QSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLDEFLEYFKS
CCCCCCCCCCCCCEECHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVII
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEE
HNLGITDRNQYLDKENAIDNVCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYL
EECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
LENIIEIKRRLELKALVGHSRKQSVLGLAKDSNLATLDRATRELSRKLEKLDIDIIRVHK
HHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]