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The map label for this gene is hemL [H]

Identifier: 134301842

GI number: 134301842

Start: 798929

End: 800224

Strand: Direct

Name: hemL [H]

Synonym: FTW_0820

Alternate gene names: 134301842

Gene position: 798929-800224 (Clockwise)

Preceding gene: 134301841

Following gene: 134301844

Centisome position: 42.08

GC content: 35.26

Gene sequence:

>1296_bases
ATGGAGAATAAATCAAACTCTCAAATTTTATTTGCAGAAGCACAGCAATATATACCAGGTGGAGTAAACTCTCCAGTTAG
GGCATTTAAGAGTGTTGGACAAGAATTTCCAAGATTTATAAAGTTTGCAAAAGGCGCTTATCTATATGATGTTGATTGGA
ACAAATACATAGACTATATTGGATCATGGGGACCGATGATTTTAGGTCATTGTGATGACGATGTTTTAGAAGCAATACAA
TGTCAGGTCAAAAATGGACTAAGCTATGGAGCACCATGTAAGCAAGAGGTTGATCTAGCTAAAAAAATAATTGAGCTAAT
GCCAAATATTGAGCAAGTAAGATTTGTAAACTCAGGTACTGAAGCTACTATGAGTGCAATCAGATTAGCAAGAGCATATA
CATGTAGAAATAAAATTATTAAATTTGAAGGCTGTTATCATGGTCATGCTGATGAGTTTCTTGTTGCAGCTGGTTCTGGT
GCGTTATCTCTAGGACAACCAAACTCTCCTGGAGTGCCGGAAGATGTTGTCAAAGATACTTTAGTAGCTAGTTTTAATGA
TATGGAGTCTATTCAAGCACTTTTTGAAAAATATAAAGATGAAATTGCTTGTATTATCGTTGAGCCAATTGCTGGTAATA
TGAATATGATTTTCCCACAAGATGACTTCTTAGCCAAACTTAGAGCTATTTGTGATCAAAATAGTAGTTTATTGATATTT
GATGAAGTGATGACTGGTTTTAGAGTTGCTTTGGGTGGTGCGCAAAGTATCTATAATGTTAAGCCAGATTTGACAACTTT
GGGTAAAGTTATTGGTGGTGGTATGCCAGTTGGGGCTTTTGGCGGACGTAAAGAGATTATGCAAAAAGTTTCTCCAGCTG
GACCAGTTTACCAAGCAGGGACACTATCTGGAAATCCTATTGCGATGACAGCAGGTATCAAAACTTTAGAAAAAATCTCA
CAACCAGGGTTATTTGATGAGCTTGGAGCTAAAGCACAAAAGCTAGTAGATGGTTTAAATGAGGCTGCTAAAGCCTATGA
TTTTAATTTTCATGCAAAATGTCTGGGCGGAATGTTTGGTTTATTTTTCTGTAGTGACAAAATTGCAGTAAATACATTTG
TAGATTTAGGCAAAACAAACCTTAAGATGTTTAATCAATTCTTTGCATATATGCTTGATAATGGTGTATATTTAGCGCCA
TCAGCTTATGAAGCAGGTTTTATTTCAATAGCTCATAGTGATGAAGATATTGAAAAAACCATTTGTCTTGCTAAAAAATT
TTTTCAAGAGAATTAG

Upstream 100 bases:

>100_bases
GGTATCCAAGAGATATACAAAGCTACAAAAATAAACGCTGCTAGTTTACTAATGCAAGCAGTTGAGAAAAAAATAAATAA
GATGAGACAGGAACACGAAA

Downstream 100 bases:

>100_bases
ATTAAAGTTGATAAATTAATTTATAAACTGACTGGTAGTACTCCTTTAATCTCTTTATTACCAAAAATATTTTCTAATGT
TGTTTGAATATTAATCTTTA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQ
CQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATMSAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSG
ALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDDFLAKLRAICDQNSSLLIF
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKIS
QPGLFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAP
SAYEAGFISIAHSDEDIEKTICLAKKFFQEN

Sequences:

>Translated_431_residues
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQ
CQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATMSAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSG
ALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDDFLAKLRAICDQNSSLLIF
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKIS
QPGLFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAP
SAYEAGFISIAHSDEDIEKTICLAKKFFQEN
>Mature_431_residues
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQ
CQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATMSAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSG
ALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDDFLAKLRAICDQNSSLLIF
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKIS
QPGLFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAP
SAYEAGFISIAHSDEDIEKTICLAKKFFQEN

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=310, Percent_Identity=29.0322580645161, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13994255, Length=371, Percent_Identity=25.3369272237197, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI37574042, Length=328, Percent_Identity=25.9146341463415, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI284507298, Length=227, Percent_Identity=29.5154185022026, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI226442709, Length=297, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI226442705, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=58.6854460093897, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1789016, Length=384, Percent_Identity=29.6875, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789759, Length=330, Percent_Identity=31.5151515151515, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788044, Length=332, Percent_Identity=31.9277108433735, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787560, Length=340, Percent_Identity=30, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI145693181, Length=336, Percent_Identity=29.7619047619048, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786991, Length=310, Percent_Identity=27.741935483871, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=378, Percent_Identity=27.2486772486773, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=355, Percent_Identity=25.0704225352113, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=197, Percent_Identity=28.4263959390863, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324432, Length=332, Percent_Identity=29.2168674698795, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=309, Percent_Identity=27.5080906148867, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357415, Length=333, Percent_Identity=25.5255255255255, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356575, Length=347, Percent_Identity=27.6657060518732, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 47079; Mature: 47079

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYI
CCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
GSWGPMILGHCDDDVLEAIQCQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCH
EATMSAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDT
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHHH
LVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDDFLAKLRAICDQNSSLLIF
HHHHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHCCCCCEEEE
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAG
HHHHHHHHHHHCCCHHHEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEECC
TLSGNPIAMTAGIKTLEKISQPGLFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFG
CCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKT
HHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCHHHHHH
ICLAKKFFQEN
HHHHHHHHHCC
>Mature Secondary Structure
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYI
CCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
GSWGPMILGHCDDDVLEAIQCQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCH
EATMSAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDT
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHHH
LVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDDFLAKLRAICDQNSSLLIF
HHHHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHCCCCCEEEE
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAG
HHHHHHHHHHHCCCHHHEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEECC
TLSGNPIAMTAGIKTLEKISQPGLFDELGAKAQKLVDGLNEAAKAYDFNFHAKCLGGMFG
CCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKT
HHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCHHHHHH
ICLAKKFFQEN
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA