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The map label for this gene is iscS [H]

Identifier: 134301755

GI number: 134301755

Start: 701814

End: 702989

Strand: Direct

Name: iscS [H]

Synonym: FTW_0720

Alternate gene names: 134301755

Gene position: 701814-702989 (Clockwise)

Preceding gene: 134301749

Following gene: 134301756

Centisome position: 36.97

GC content: 35.12

Gene sequence:

>1176_bases
ATGAGTCTTATTTATTTAGATTATGCTGCGACAACTCCTCTTAGTCAAAGTGTCAAAAACTCTATGTTAAACTCTATAAC
TAGTGATGATGATTTTTTTAATTCTGGATCATTGACATATCAACAAGCAGAAATTGTTAGTAATAAAATTGAACAAGCAA
GGGCTACAATTGCACAAACTCTAGAGGTATTACCAAGGGAGGTCATTTTTACATCGGGAGCAACAGAGTCAAATAACCTT
GCGATAAAAGGAGTAGCATATGCATATAAAGATAGAGGCAGACATATAATAACATCAAAAGCTGAGCATAAGGCAGTATT
AGATGTATGTAAGTTTTTAGAGACACAGGGGTTTGATGTTACATACCTTGATGTTAACCAGTTTGGTGAGGTTGATTTAG
AGCAGCTTAAAAAAGCTATCACGCCACAAACAATACTTGTAAGTTTAATGGCTGTAAATAATGAACTCGGGACAAAAAAT
AATCTTATAGAAATTGGTAAAATAACCAAGCAAAAGGGCGTGATGCTGCATGTTGATGCTGCCCAGGGTTATGGCAAAGT
TGATATAGATATCAAAGCGATGAATATTGATCTATTATCAGTGTCTGGGCATAAGTTATATGCACCAAAAGGTGTTGGTT
TTTTGTATCTAAGATCGAAACGACCAAAAGTTAGGCTTGTAAAGCAAATACATGGAGGGGCTCAAGAGTTTAATTTACGC
GCAGGGACATTAGCAACCTATCAGATATTTGCATTAGCTATAGCCGTTAAAGAGATGTTTGCTAAAAAACAACAAAACTT
TGAATATGTGTTAGAAATGCGTCGAGTTTTTTTAGATATTATTCAGGATTTGGCTAGTATAAAAATTAATACAGATCTTG
AGAATAGTTACCCAGGTATTTTAAGTGTGACATTTTTAGGAGTAAAAGGTGAAACGCTATTAGCATTAGTTGATGGGGTT
TGTATGTCAATGGGCTCAGCGTGCAATTCTCAGGCAGTTGAGCCTTCACATGTGTTAAGTGCCATAGGTTTGACAGCAAC
TCAAGCAGAGTCAACACTTAGAATATCTTTTGGGTTACAAACAAATAAAAAGCAAGTTATTCAAGCGGCAAATTTGCTAA
AAGAAAAAGTACAACTTTTACGAGCTTTATCTCCTCAAGGAGAAGTAAATGTATAA

Upstream 100 bases:

>100_bases
ATTTGCTTAATCTAGATGCGATTTTGTTAAAGTACTATGTACACAATTATTTGATATAATAGCAATATTAGCTATTAAAT
AAAAGAATTATTAATTTGTA

Downstream 100 bases:

>100_bases
TGATTTGACTCGAGAACTTTTAAGACAAGTTAAATTTGAAGATGGAATTATCTTAGCGGAACAGACTAAATATAGCGTTA
GTGATAGTTTTTTAACGGTT

Product: cysteine desulfarase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSLIYLDYAATTPLSQSVKNSMLNSITSDDDFFNSGSLTYQQAEIVSNKIEQARATIAQTLEVLPREVIFTSGATESNNL
AIKGVAYAYKDRGRHIITSKAEHKAVLDVCKFLETQGFDVTYLDVNQFGEVDLEQLKKAITPQTILVSLMAVNNELGTKN
NLIEIGKITKQKGVMLHVDAAQGYGKVDIDIKAMNIDLLSVSGHKLYAPKGVGFLYLRSKRPKVRLVKQIHGGAQEFNLR
AGTLATYQIFALAIAVKEMFAKKQQNFEYVLEMRRVFLDIIQDLASIKINTDLENSYPGILSVTFLGVKGETLLALVDGV
CMSMGSACNSQAVEPSHVLSAIGLTATQAESTLRISFGLQTNKKQVIQAANLLKEKVQLLRALSPQGEVNV

Sequences:

>Translated_391_residues
MSLIYLDYAATTPLSQSVKNSMLNSITSDDDFFNSGSLTYQQAEIVSNKIEQARATIAQTLEVLPREVIFTSGATESNNL
AIKGVAYAYKDRGRHIITSKAEHKAVLDVCKFLETQGFDVTYLDVNQFGEVDLEQLKKAITPQTILVSLMAVNNELGTKN
NLIEIGKITKQKGVMLHVDAAQGYGKVDIDIKAMNIDLLSVSGHKLYAPKGVGFLYLRSKRPKVRLVKQIHGGAQEFNLR
AGTLATYQIFALAIAVKEMFAKKQQNFEYVLEMRRVFLDIIQDLASIKINTDLENSYPGILSVTFLGVKGETLLALVDGV
CMSMGSACNSQAVEPSHVLSAIGLTATQAESTLRISFGLQTNKKQVIQAANLLKEKVQLLRALSPQGEVNV
>Mature_390_residues
SLIYLDYAATTPLSQSVKNSMLNSITSDDDFFNSGSLTYQQAEIVSNKIEQARATIAQTLEVLPREVIFTSGATESNNLA
IKGVAYAYKDRGRHIITSKAEHKAVLDVCKFLETQGFDVTYLDVNQFGEVDLEQLKKAITPQTILVSLMAVNNELGTKNN
LIEIGKITKQKGVMLHVDAAQGYGKVDIDIKAMNIDLLSVSGHKLYAPKGVGFLYLRSKRPKVRLVKQIHGGAQEFNLRA
GTLATYQIFALAIAVKEMFAKKQQNFEYVLEMRRVFLDIIQDLASIKINTDLENSYPGILSVTFLGVKGETLLALVDGVC
MSMGSACNSQAVEPSHVLSAIGLTATQAESTLRISFGLQTNKKQVIQAANLLKEKVQLLRALSPQGEVNV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=391, Percent_Identity=42.1994884910486, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI156713448, Length=415, Percent_Identity=29.1566265060241, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=42.4870466321244, Blast_Score=331, Evalue=6e-92,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=25.6857855361596, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787970, Length=229, Percent_Identity=30.1310043668122, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=392, Percent_Identity=44.6428571428571, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17533177, Length=334, Percent_Identity=32.0359281437126, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319831, Length=389, Percent_Identity=41.1311053984576, Blast_Score=299, Evalue=5e-82,
Organism=Drosophila melanogaster, GI20129463, Length=388, Percent_Identity=43.298969072165, Blast_Score=306, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42868; Mature: 42737

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIYLDYAATTPLSQSVKNSMLNSITSDDDFFNSGSLTYQQAEIVSNKIEQARATIAQT
CEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LEVLPREVIFTSGATESNNLAIKGVAYAYKDRGRHIITSKAEHKAVLDVCKFLETQGFDV
HHHCCHHHEEECCCCCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCEE
TYLDVNQFGEVDLEQLKKAITPQTILVSLMAVNNELGTKNNLIEIGKITKQKGVMLHVDA
EEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEECCHHCCCCEEEEEEC
AQGYGKVDIDIKAMNIDLLSVSGHKLYAPKGVGFLYLRSKRPKVRLVKQIHGGAQEFNLR
CCCCCEEEEEEEEEEEEEEEECCCEEECCCCCEEEEEECCCCHHHHHHHHCCCHHHCCEE
AGTLATYQIFALAIAVKEMFAKKQQNFEYVLEMRRVFLDIIQDLASIKINTDLENSYPGI
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCE
LSVTFLGVKGETLLALVDGVCMSMGSACNSQAVEPSHVLSAIGLTATQAESTLRISFGLQ
EEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEECCCCEEEEEECCC
TNKKQVIQAANLLKEKVQLLRALSPQGEVNV
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLIYLDYAATTPLSQSVKNSMLNSITSDDDFFNSGSLTYQQAEIVSNKIEQARATIAQT
EEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LEVLPREVIFTSGATESNNLAIKGVAYAYKDRGRHIITSKAEHKAVLDVCKFLETQGFDV
HHHCCHHHEEECCCCCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCEE
TYLDVNQFGEVDLEQLKKAITPQTILVSLMAVNNELGTKNNLIEIGKITKQKGVMLHVDA
EEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEECCHHCCCCEEEEEEC
AQGYGKVDIDIKAMNIDLLSVSGHKLYAPKGVGFLYLRSKRPKVRLVKQIHGGAQEFNLR
CCCCCEEEEEEEEEEEEEEEECCCEEECCCCCEEEEEECCCCHHHHHHHHCCCHHHCCEE
AGTLATYQIFALAIAVKEMFAKKQQNFEYVLEMRRVFLDIIQDLASIKINTDLENSYPGI
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCE
LSVTFLGVKGETLLALVDGVCMSMGSACNSQAVEPSHVLSAIGLTATQAESTLRISFGLQ
EEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEECCCCEEEEEECCC
TNKKQVIQAANLLKEKVQLLRALSPQGEVNV
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA