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The map label for this gene is fba [H]

Identifier: 134301593

GI number: 134301593

Start: 513873

End: 514937

Strand: Direct

Name: fba [H]

Synonym: FTW_0526

Alternate gene names: 134301593

Gene position: 513873-514937 (Clockwise)

Preceding gene: 134301592

Following gene: 134301594

Centisome position: 27.07

GC content: 39.15

Gene sequence:

>1065_bases
ATGGCTTTAGTTTCATTGCGTCAACTATTAGATCATGCTGCTGAGCATGGTTATGGATTACCAGCTTTTAATGTTAATAA
CCTTGAACAGGTTAGGGCTGTTATGGAAGCTGCGGATAAGGTTAACTCACCAGTTATTTTACAAGGTTCGGCTGGAGCAA
GAAAGTATGCTGGAGCATCTTTTATTAGGCATCTAGTTTTAGCTGCAATAGAAGAATATCCACATATCCCAGTATGTATG
CACCAAGATCATGGTACATCTCCATCAGTTTGTCAAAGATCTATCCAATTAGGTTTTTCATCTGTGATGATGGATGGTTC
TCTAAAATCAGATGGTAAAACTCCAGCTGACTACGAATATAATGTTAATGTTACAAAAACAGTTTCTGATATGGCTCATG
CTTGTGGCGTATCGGTTGAGGGTGAGTTAGGTTGCCTTGGTTCGTTAGAAACTGGACAAGCTGGCGAAGAAGATGGTATA
GGTGCTGAAGGTACTTTATCTATGGATCAATTACTTACTGACCCTGAAGAGGCAGCTGATTTTGTTAGAAGAACTAAAGT
TGATGCTTTAGCTATAGCTATCGGTACTTCGCATGGTGCTTATAAGTTCACAAAACCACCTACAGGTGATGTATTATCTA
TCAAAAGAGTAAAAGAGATTCATGCAAGAATACCTGATACTCACTTAGTAATGCATGGTTCATCTTCTGTGCCACAAGAC
TGGTTAGAAGTAATCAATACTTATGGCGGTGCTATGGGAGAAACTTATGGTGTACCTGTAGAGGAAATCGTTGAAGCTAT
AAAGTATAGCGTACGTAAGATAAATATTGATACAGATCTACGTATGGCAGCTACTGGTGCTATCAGAAGATTTTTAGCTG
AGAATCCAGCTGAATTTGATCCACGCAAGTATAATGCTGTTGCCAAAGCAGCAATGTCAGAGATTTGTGCGGCCCGTTAT
GAAGCATTTGGTAGTGCTGGTATGGCGAGCAAAATTAAGCCTATATCTCTTGAAATTATGTTTCAACGCTATGAGAGTGG
TGAGTTAGATCCAATTGTTAAATAA

Upstream 100 bases:

>100_bases
TTTTGTGCTTACTAGTGGCGATAGTATGGGTGTACATGGAAGCACTAATAAGATTAAAGTGATAATTGCAGGTCAGGTAA
GATAAAAGGAGATAATAATA

Downstream 100 bases:

>100_bases
TAAACTTTTAAAATTTTAGATAATAGTTTTAGATATTTTTCATAATCTCTATTTATAATTTAAAAAATTTTAAACTCTTA
TAGTCGTTAACTGATAAATC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MALVSLRQLLDHAAEHGYGLPAFNVNNLEQVRAVMEAADKVNSPVILQGSAGARKYAGASFIRHLVLAAIEEYPHIPVCM
HQDHGTSPSVCQRSIQLGFSSVMMDGSLKSDGKTPADYEYNVNVTKTVSDMAHACGVSVEGELGCLGSLETGQAGEEDGI
GAEGTLSMDQLLTDPEEAADFVRRTKVDALAIAIGTSHGAYKFTKPPTGDVLSIKRVKEIHARIPDTHLVMHGSSSVPQD
WLEVINTYGGAMGETYGVPVEEIVEAIKYSVRKINIDTDLRMAATGAIRRFLAENPAEFDPRKYNAVAKAAMSEICAARY
EAFGSAGMASKIKPISLEIMFQRYESGELDPIVK

Sequences:

>Translated_354_residues
MALVSLRQLLDHAAEHGYGLPAFNVNNLEQVRAVMEAADKVNSPVILQGSAGARKYAGASFIRHLVLAAIEEYPHIPVCM
HQDHGTSPSVCQRSIQLGFSSVMMDGSLKSDGKTPADYEYNVNVTKTVSDMAHACGVSVEGELGCLGSLETGQAGEEDGI
GAEGTLSMDQLLTDPEEAADFVRRTKVDALAIAIGTSHGAYKFTKPPTGDVLSIKRVKEIHARIPDTHLVMHGSSSVPQD
WLEVINTYGGAMGETYGVPVEEIVEAIKYSVRKINIDTDLRMAATGAIRRFLAENPAEFDPRKYNAVAKAAMSEICAARY
EAFGSAGMASKIKPISLEIMFQRYESGELDPIVK
>Mature_353_residues
ALVSLRQLLDHAAEHGYGLPAFNVNNLEQVRAVMEAADKVNSPVILQGSAGARKYAGASFIRHLVLAAIEEYPHIPVCMH
QDHGTSPSVCQRSIQLGFSSVMMDGSLKSDGKTPADYEYNVNVTKTVSDMAHACGVSVEGELGCLGSLETGQAGEEDGIG
AEGTLSMDQLLTDPEEAADFVRRTKVDALAIAIGTSHGAYKFTKPPTGDVLSIKRVKEIHARIPDTHLVMHGSSSVPQDW
LEVINTYGGAMGETYGVPVEEIVEAIKYSVRKINIDTDLRMAATGAIRRFLAENPAEFDPRKYNAVAKAAMSEICAARYE
AFGSAGMASKIKPISLEIMFQRYESGELDPIVK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=333, Percent_Identity=34.5345345345345, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=33.1306990881459, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1788072, Length=330, Percent_Identity=29.6969696969697, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789293, Length=330, Percent_Identity=24.5454545454545, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38146; Mature: 38015

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVSLRQLLDHAAEHGYGLPAFNVNNLEQVRAVMEAADKVNSPVILQGSAGARKYAGAS
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIRHLVLAAIEEYPHIPVCMHQDHGTSPSVCQRSIQLGFSSVMMDGSLKSDGKTPADYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVNVTKTVSDMAHACGVSVEGELGCLGSLETGQAGEEDGIGAEGTLSMDQLLTDPEEAAD
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHH
FVRRTKVDALAIAIGTSHGAYKFTKPPTGDVLSIKRVKEIHARIPDTHLVMHGSSSVPQD
HHHHHHHHEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLEVINTYGGAMGETYGVPVEEIVEAIKYSVRKINIDTDLRMAATGAIRRFLAENPAEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRKYNAVAKAAMSEICAARYEAFGSAGMASKIKPISLEIMFQRYESGELDPIVK
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHEEHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ALVSLRQLLDHAAEHGYGLPAFNVNNLEQVRAVMEAADKVNSPVILQGSAGARKYAGAS
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIRHLVLAAIEEYPHIPVCMHQDHGTSPSVCQRSIQLGFSSVMMDGSLKSDGKTPADYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVNVTKTVSDMAHACGVSVEGELGCLGSLETGQAGEEDGIGAEGTLSMDQLLTDPEEAAD
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHH
FVRRTKVDALAIAIGTSHGAYKFTKPPTGDVLSIKRVKEIHARIPDTHLVMHGSSSVPQD
HHHHHHHHEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLEVINTYGGAMGETYGVPVEEIVEAIKYSVRKINIDTDLRMAATGAIRRFLAENPAEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRKYNAVAKAAMSEICAARYEAFGSAGMASKIKPISLEIMFQRYESGELDPIVK
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHEEHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]