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The map label for this gene is manC [H]

Identifier: 134301527

GI number: 134301527

Start: 446657

End: 448063

Strand: Reverse

Name: manC [H]

Synonym: FTW_0453

Alternate gene names: 134301527

Gene position: 448063-446657 (Counterclockwise)

Preceding gene: 134301533

Following gene: 134301526

Centisome position: 23.6

GC content: 36.46

Gene sequence:

>1407_bases
ATGATTACTCCTATTATCTTATCTGGAGGATTCGGCTCAAGGCTATGGCCACTATCACGAGAGGCATCGCCAAAGCAGTT
TATCGGCTTGGTTGATGAACATAGTCTATTAGAAAATACAATTAAGCGACTAGATAATGTCAAGGATATAACTTCACCTG
TAGTTGTCTGTAATGAAAGTCATAGATTCCAAGTTGCTGAAGTGTTGCGGAAAATCAATAAAAAAGGCGATATACTCCTA
GAGCCATTAGCCAGAAATACTGCTCCAGCAATTGCACTTGCAGCACTACATTTAGCTACTAATGATCCAAATACAATTAT
GCTAGTTTTAGCTGCTGACCATCATATTGAAAATCTGGAGATTTTTCATCAAGCTATCGAAAAAGCACAGCAAAAAGTTA
TTAAAGATGATTCTTTAGTTACCTTTGGCATTACACCAACTTGTCCTCATGAAGGCTATGGTTATATTAAACAAGGGGTA
CAGACTACTGTAAATGGAGTTTATAAGGTAGATAAATTTGTTGAGAAGCCTAGTGTGGTCGTTGCACAAGAGTATTTAGA
TAGTGGCAAATACTATTGGAATAGCGGTATGTTTATGTTCACAGCTAGAGCATATTTAGAGGCTTTAGAGAAGTTACAGC
CAGAGATTTACAGAGGATGTGAAAAAACTTATCAAAAGTCACAGCAGGATTTAGATTTTGTGCGTTTTGATAAACAAAGC
TTTGCCCTAGTTCAATCACAGTCAATAGACTACGCAGTTATGGAGAAAGCAACTAATGTTGCTATAGTGCCTATGCAACA
AAGTGGCTGGTCTGATGTTGGCTCTTGGGACTCTTTGTATGATATTGCTGCAAAAGATAGTTGTGGTAATGTGGTTATTG
GCGATGTGATTACTAGTAATGTCAAAAATAGTTATTTACGCTCGCATGATCGTTTATTGGCTGCAGTCGGAGTTAATGAT
TTAATAATTGTTGAAACAGCAGATGCTATACTTGTCGCGGATAAGAACAAAACTCAAGATGTCAAAAAAATAGTCGAAGT
TTTGAAAATTCAGCAGCGAAGTGAATTATTACAGCATAAGCAAATTTATAAACCTTGGGGTTCAGCGACAATATTAGAGG
ATAAGTCTGGTTATAAGATACAGGCGATTCAACTTGAACCGGGCAAGAAGTTATCATTACAGCAACATTATCACCGTAGT
GAGCATTGGATTGTGATTTCTGGAACTGCTACGGTAACTATTGGTACTACTAAGTCTATTGTTAGACCAAATGAGTCTGT
ATATATAAAAATAGGCGAATCTCACAGACTTGAAAATAATGGCAAGATTCCAGTTATTCTTATAGAAGTACAAGTTGGAG
AATATATAAGTGAAGACGATATTGTTAGACTAGATACAAGTAGTTAA

Upstream 100 bases:

>100_bases
AGTAAGTTAAGTTATGACAATATTTAATTTGCTGATTTATTGTTGAATATATTAGCTTTCTATATAATTAATCAATATCA
AAGTTATTTAGGTTTTTATA

Downstream 100 bases:

>100_bases
TATAAAAACAATTAGATAGAAAAAAATATAATGAGACAAACTATAATAAAAGAAATAATCAAATCTAGCGGCGTAAAGTT
TGGTACTAGTGGAGTTAGAG

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MITPIILSGGFGSRLWPLSREASPKQFIGLVDEHSLLENTIKRLDNVKDITSPVVVCNESHRFQVAEVLRKINKKGDILL
EPLARNTAPAIALAALHLATNDPNTIMLVLAADHHIENLEIFHQAIEKAQQKVIKDDSLVTFGITPTCPHEGYGYIKQGV
QTTVNGVYKVDKFVEKPSVVVAQEYLDSGKYYWNSGMFMFTARAYLEALEKLQPEIYRGCEKTYQKSQQDLDFVRFDKQS
FALVQSQSIDYAVMEKATNVAIVPMQQSGWSDVGSWDSLYDIAAKDSCGNVVIGDVITSNVKNSYLRSHDRLLAAVGVND
LIIVETADAILVADKNKTQDVKKIVEVLKIQQRSELLQHKQIYKPWGSATILEDKSGYKIQAIQLEPGKKLSLQQHYHRS
EHWIVISGTATVTIGTTKSIVRPNESVYIKIGESHRLENNGKIPVILIEVQVGEYISEDDIVRLDTSS

Sequences:

>Translated_468_residues
MITPIILSGGFGSRLWPLSREASPKQFIGLVDEHSLLENTIKRLDNVKDITSPVVVCNESHRFQVAEVLRKINKKGDILL
EPLARNTAPAIALAALHLATNDPNTIMLVLAADHHIENLEIFHQAIEKAQQKVIKDDSLVTFGITPTCPHEGYGYIKQGV
QTTVNGVYKVDKFVEKPSVVVAQEYLDSGKYYWNSGMFMFTARAYLEALEKLQPEIYRGCEKTYQKSQQDLDFVRFDKQS
FALVQSQSIDYAVMEKATNVAIVPMQQSGWSDVGSWDSLYDIAAKDSCGNVVIGDVITSNVKNSYLRSHDRLLAAVGVND
LIIVETADAILVADKNKTQDVKKIVEVLKIQQRSELLQHKQIYKPWGSATILEDKSGYKIQAIQLEPGKKLSLQQHYHRS
EHWIVISGTATVTIGTTKSIVRPNESVYIKIGESHRLENNGKIPVILIEVQVGEYISEDDIVRLDTSS
>Mature_468_residues
MITPIILSGGFGSRLWPLSREASPKQFIGLVDEHSLLENTIKRLDNVKDITSPVVVCNESHRFQVAEVLRKINKKGDILL
EPLARNTAPAIALAALHLATNDPNTIMLVLAADHHIENLEIFHQAIEKAQQKVIKDDSLVTFGITPTCPHEGYGYIKQGV
QTTVNGVYKVDKFVEKPSVVVAQEYLDSGKYYWNSGMFMFTARAYLEALEKLQPEIYRGCEKTYQKSQQDLDFVRFDKQS
FALVQSQSIDYAVMEKATNVAIVPMQQSGWSDVGSWDSLYDIAAKDSCGNVVIGDVITSNVKNSYLRSHDRLLAAVGVND
LIIVETADAILVADKNKTQDVKKIVEVLKIQQRSELLQHKQIYKPWGSATILEDKSGYKIQAIQLEPGKKLSLQQHYHRS
EHWIVISGTATVTIGTTKSIVRPNESVYIKIGESHRLENNGKIPVILIEVQVGEYISEDDIVRLDTSS

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=469, Percent_Identity=48.1876332622601, Blast_Score=438, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 52347; Mature: 52347

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPIILSGGFGSRLWPLSREASPKQFIGLVDEHSLLENTIKRLDNVKDITSPVVVCNES
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCEEEECCC
HRFQVAEVLRKINKKGDILLEPLARNTAPAIALAALHLATNDPNTIMLVLAADHHIENLE
CCCHHHHHHHHHCCCCCEEEECHHCCCCHHHHHHEEEEECCCCCEEEEEEECCCCCHHHH
IFHQAIEKAQQKVIKDDSLVTFGITPTCPHEGYGYIKQGVQTTVNGVYKVDKFVEKPSVV
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
VAQEYLDSGKYYWNSGMFMFTARAYLEALEKLQPEIYRGCEKTYQKSQQDLDFVRFDKQS
EEHHHHHCCCEEEECCEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHEEECCHH
FALVQSQSIDYAVMEKATNVAIVPMQQSGWSDVGSWDSLYDIAAKDSCGNVVIGDVITSN
HEEECCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCEEECHHHHHH
VKNSYLRSHDRLLAAVGVNDLIIVETADAILVADKNKTQDVKKIVEVLKIQQRSELLQHK
HHHHHHHHHHHEEEEECCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QIYKPWGSATILEDKSGYKIQAIQLEPGKKLSLQQHYHRSEHWIVISGTATVTIGTTKSI
HHHCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHCCCCCEEEEECCEEEEECCCHHH
VRPNESVYIKIGESHRLENNGKIPVILIEVQVGEYISEDDIVRLDTSS
CCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEECCC
>Mature Secondary Structure
MITPIILSGGFGSRLWPLSREASPKQFIGLVDEHSLLENTIKRLDNVKDITSPVVVCNES
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCEEEECCC
HRFQVAEVLRKINKKGDILLEPLARNTAPAIALAALHLATNDPNTIMLVLAADHHIENLE
CCCHHHHHHHHHCCCCCEEEECHHCCCCHHHHHHEEEEECCCCCEEEEEEECCCCCHHHH
IFHQAIEKAQQKVIKDDSLVTFGITPTCPHEGYGYIKQGVQTTVNGVYKVDKFVEKPSVV
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
VAQEYLDSGKYYWNSGMFMFTARAYLEALEKLQPEIYRGCEKTYQKSQQDLDFVRFDKQS
EEHHHHHCCCEEEECCEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHEEECCHH
FALVQSQSIDYAVMEKATNVAIVPMQQSGWSDVGSWDSLYDIAAKDSCGNVVIGDVITSN
HEEECCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCEEECHHHHHH
VKNSYLRSHDRLLAAVGVNDLIIVETADAILVADKNKTQDVKKIVEVLKIQQRSELLQHK
HHHHHHHHHHHEEEEECCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QIYKPWGSATILEDKSGYKIQAIQLEPGKKLSLQQHYHRSEHWIVISGTATVTIGTTKSI
HHHCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHCCCCCEEEEECCEEEEECCCHHH
VRPNESVYIKIGESHRLENNGKIPVILIEVQVGEYISEDDIVRLDTSS
CCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]