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The map label for this gene is wbtM [H]

Identifier: 134301507

GI number: 134301507

Start: 424583

End: 425584

Strand: Direct

Name: wbtM [H]

Synonym: FTW_0426

Alternate gene names: 134301507

Gene position: 424583-425584 (Clockwise)

Preceding gene: 134301506

Following gene: 134301508

Centisome position: 22.36

GC content: 33.83

Gene sequence:

>1002_bases
ATGAACTACAAACCAAAAAATATCCTAGTAACAGGTGCGGCGGGATTTATTGGTAGTAACTATGTGCGTATGATGTTATC
ACGCTATAGTGATATCAAAATAATCTCGTATGATAAGCTTACTTATGCGGGTAGTTTAGATAATCTAAAAGACTTGAATA
ATGAACATAACCATACTTTTATAAAAGGTGATATTTGTGATGAAGTTTTAGTATATCAAACAATGAAAGAATATAAAATT
GATACGATAGTACATTTTGCTGCAGAATCGCATGTTGATAATTCAATTGCTAATCCAAAGGTGTTTTTAGAAACGAATGT
GATAGGTACATTTACACTTTTAGATTGTGCTAAAAGGTATTGGTTAGATGAGCTAGGTTTAGAAGAAACTAGTTGTAGGT
TTCATCATGTATCTACTGATGAGGTATATGGTACCTTGGCAAAAGATGAACCAGCCTTTACTGAGATTAAGGCTTATGAG
CCAAATTCACCGTATTCGGCATCTAAGGCGGGATCTGATCATATTGCTAGAGCATATCATCATACCTATAAACTTCCGGT
AACAATTTCAAATTGTTCAAACAACTATGGACCATACCAACATCGAGAGAAATTAATCCCTGTAGTGATAAATAGTTGTA
TAAACTACAAGCCTATTCCTGTTTACGGAGATGGTTCGAATATTCGAGATTGGCTATATGTAGAAGATCACTGCGATGCT
ATCCAGACAATTGTTGAGAAAGGAGTGGTTGGAGAGGTTTATAATATTGGTGGTATTAATGAAGTTGATAATCTAACCTT
GGTAAAAACTATCTGTAAACTAATGGATGAATATAAACCAGAAAATGCTCCACATTCTAACTTAATCACATTTGTGGAAG
ATAGAAAAGGACATGATTGGCGTTATGCTATTGATAACAGCAAGATTCAGAATGAGTTAGGATGGAAGCCATCACAAGAT
TTTGATAAGATGTTTAGACAAACTATTGAGTTTTATCTATAG

Upstream 100 bases:

>100_bases
TTACCGCCTACGCGGTAATGACAAGTTTATGCGGTAATGATAGTTTAGTGAGAGAATGACTAGTCACTATAGGAATGATG
ATGTAATGAGGAATGAAAAA

Downstream 100 bases:

>100_bases
CTTAAATATTTATCTTATGAGTATCTCTAAAAAATCAATTTAATTTATTTTTGTGTTAAAAAGTAGTGTTTGCAAGAATA
TAGTTAATCCGAAAGATATT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNYKPKNILVTGAAGFIGSNYVRMMLSRYSDIKIISYDKLTYAGSLDNLKDLNNEHNHTFIKGDICDEVLVYQTMKEYKI
DTIVHFAAESHVDNSIANPKVFLETNVIGTFTLLDCAKRYWLDELGLEETSCRFHHVSTDEVYGTLAKDEPAFTEIKAYE
PNSPYSASKAGSDHIARAYHHTYKLPVTISNCSNNYGPYQHREKLIPVVINSCINYKPIPVYGDGSNIRDWLYVEDHCDA
IQTIVEKGVVGEVYNIGGINEVDNLTLVKTICKLMDEYKPENAPHSNLITFVEDRKGHDWRYAIDNSKIQNELGWKPSQD
FDKMFRQTIEFYL

Sequences:

>Translated_333_residues
MNYKPKNILVTGAAGFIGSNYVRMMLSRYSDIKIISYDKLTYAGSLDNLKDLNNEHNHTFIKGDICDEVLVYQTMKEYKI
DTIVHFAAESHVDNSIANPKVFLETNVIGTFTLLDCAKRYWLDELGLEETSCRFHHVSTDEVYGTLAKDEPAFTEIKAYE
PNSPYSASKAGSDHIARAYHHTYKLPVTISNCSNNYGPYQHREKLIPVVINSCINYKPIPVYGDGSNIRDWLYVEDHCDA
IQTIVEKGVVGEVYNIGGINEVDNLTLVKTICKLMDEYKPENAPHSNLITFVEDRKGHDWRYAIDNSKIQNELGWKPSQD
FDKMFRQTIEFYL
>Mature_333_residues
MNYKPKNILVTGAAGFIGSNYVRMMLSRYSDIKIISYDKLTYAGSLDNLKDLNNEHNHTFIKGDICDEVLVYQTMKEYKI
DTIVHFAAESHVDNSIANPKVFLETNVIGTFTLLDCAKRYWLDELGLEETSCRFHHVSTDEVYGTLAKDEPAFTEIKAYE
PNSPYSASKAGSDHIARAYHHTYKLPVTISNCSNNYGPYQHREKLIPVVINSCINYKPIPVYGDGSNIRDWLYVEDHCDA
IQTIVEKGVVGEVYNIGGINEVDNLTLVKTICKLMDEYKPENAPHSNLITFVEDRKGHDWRYAIDNSKIQNELGWKPSQD
FDKMFRQTIEFYL

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=327, Percent_Identity=37.9204892966361, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI42516563, Length=332, Percent_Identity=23.4939759036145, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4504031, Length=354, Percent_Identity=24.5762711864407, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI48994969, Length=333, Percent_Identity=51.6516516516517, Blast_Score=348, Evalue=2e-97,
Organism=Escherichia coli, GI1788353, Length=334, Percent_Identity=50, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI1786974, Length=347, Percent_Identity=25.9365994236311, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788366, Length=240, Percent_Identity=25, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17568069, Length=336, Percent_Identity=35.4166666666667, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI115532424, Length=332, Percent_Identity=30.7228915662651, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17539532, Length=242, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=262, Percent_Identity=25.9541984732824, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356223, Length=338, Percent_Identity=24.5562130177515, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19923002, Length=362, Percent_Identity=26.5193370165746, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38124; Mature: 38124

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKPKNILVTGAAGFIGSNYVRMMLSRYSDIKIISYDKLTYAGSLDNLKDLNNEHNHTF
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCHHHHHCCCCCCCEE
IKGDICDEVLVYQTMKEYKIDTIVHFAAESHVDNSIANPKVFLETNVIGTFTLLDCAKRY
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
WLDELGLEETSCRFHHVSTDEVYGTLAKDEPAFTEIKAYEPNSPYSASKAGSDHIARAYH
HHHHCCCCCCCCEEEECCHHHHHEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
HTYKLPVTISNCSNNYGPYQHREKLIPVVINSCINYKPIPVYGDGSNIRDWLYVEDHCDA
HEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEHHHHHH
IQTIVEKGVVGEVYNIGGINEVDNLTLVKTICKLMDEYKPENAPHSNLITFVEDRKGHDW
HHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCE
RYAIDNSKIQNELGWKPSQDFDKMFRQTIEFYL
EEEECCCHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYKPKNILVTGAAGFIGSNYVRMMLSRYSDIKIISYDKLTYAGSLDNLKDLNNEHNHTF
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCHHHHHCCCCCCCEE
IKGDICDEVLVYQTMKEYKIDTIVHFAAESHVDNSIANPKVFLETNVIGTFTLLDCAKRY
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
WLDELGLEETSCRFHHVSTDEVYGTLAKDEPAFTEIKAYEPNSPYSASKAGSDHIARAYH
HHHHCCCCCCCCEEEECCHHHHHEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
HTYKLPVTISNCSNNYGPYQHREKLIPVVINSCINYKPIPVYGDGSNIRDWLYVEDHCDA
HEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEHHHHHH
IQTIVEKGVVGEVYNIGGINEVDNLTLVKTICKLMDEYKPENAPHSNLITFVEDRKGHDW
HHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCE
RYAIDNSKIQNELGWKPSQDFDKMFRQTIEFYL
EEEECCCHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]