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The map label for this gene is rnc [H]

Identifier: 134301463

GI number: 134301463

Start: 366460

End: 367152

Strand: Direct

Name: rnc [H]

Synonym: FTW_0372

Alternate gene names: 134301463

Gene position: 366460-367152 (Clockwise)

Preceding gene: 134301462

Following gene: 134301464

Centisome position: 19.3

GC content: 33.48

Gene sequence:

>693_bases
ATGGTTCCTGAATATTCACGATTTTATAACATTCTTGGATATAATTTCAAAGATTGTACTCTTCTCATAAGAGCCTTAAC
TCATCGAAGTAAGACTAAGAAAAATTATGAAAGATTAGAGTTTCTTGGTGACTCTGTTCTAAGTTTTGTAATTGCTGAAG
TTTTGTATAAACAATTTACAGATTTGGCTGAAGGAAAACTATCGCAACTAAGATCTAAACTAGTCAAAGGAACAACTTTA
GCACAATTAGCTTCGAGTCTCAAAATGGATGAGTACATTATCTTAGGTGCTAGTGAACAGGGCGGTCACAAGCGTGAGAA
AATATTAGAAGATGTTTTTGAAGCTGTGATAGGAGCTATCTATCTAGATAGTGATTTTGCAACAGTCAAGAAAGTTATAT
TAAAATGGTATCAGCCAATAATATCGAGTATCAATCTGGACACTATCAAAGTCAAAGATAGCAAATCAAAGCTTCAAGAG
ATTTTGCTACAGAATGCTTTGAGTTTGCCAGAATATAGTATTGAAACTATAGATGGTAAAGACCATGAGCAGCAATTTAC
TGTAGTTGCTGTGTCAAAAGATTTAAATCTTCGAGTTAAAGCTCAGGGCACTTCACGGAAAAAAGCTGAGCAAAAAACTG
CTGAAAAAATGATAGAAATGTTATCACAACAAGGCTTACATGAAAAAAAATAG

Upstream 100 bases:

>100_bases
CAAAGATCTAGTTGGTAAAGCAAAAGTTGTTTGGATGAGCTGGGATAAGATAGATAAAAAGGTTCGCTGGGATGAAATTG
GTAAGGTCTTTTAATTAAAA

Downstream 100 bases:

>100_bases
ACTAAACTTAAATGGTGTGGTTGTTATTAATAAGGCTAAAGATATTAGTTCAAATAAAGTTTTACAGCAATTAAAGTATT
TATTTAATGCACAAAAAGTA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MVPEYSRFYNILGYNFKDCTLLIRALTHRSKTKKNYERLEFLGDSVLSFVIAEVLYKQFTDLAEGKLSQLRSKLVKGTTL
AQLASSLKMDEYIILGASEQGGHKREKILEDVFEAVIGAIYLDSDFATVKKVILKWYQPIISSINLDTIKVKDSKSKLQE
ILLQNALSLPEYSIETIDGKDHEQQFTVVAVSKDLNLRVKAQGTSRKKAEQKTAEKMIEMLSQQGLHEKK

Sequences:

>Translated_230_residues
MVPEYSRFYNILGYNFKDCTLLIRALTHRSKTKKNYERLEFLGDSVLSFVIAEVLYKQFTDLAEGKLSQLRSKLVKGTTL
AQLASSLKMDEYIILGASEQGGHKREKILEDVFEAVIGAIYLDSDFATVKKVILKWYQPIISSINLDTIKVKDSKSKLQE
ILLQNALSLPEYSIETIDGKDHEQQFTVVAVSKDLNLRVKAQGTSRKKAEQKTAEKMIEMLSQQGLHEKK
>Mature_230_residues
MVPEYSRFYNILGYNFKDCTLLIRALTHRSKTKKNYERLEFLGDSVLSFVIAEVLYKQFTDLAEGKLSQLRSKLVKGTTL
AQLASSLKMDEYIILGASEQGGHKREKILEDVFEAVIGAIYLDSDFATVKKVILKWYQPIISSINLDTIKVKDSKSKLQE
ILLQNALSLPEYSIETIDGKDHEQQFTVVAVSKDLNLRVKAQGTSRKKAEQKTAEKMIEMLSQQGLHEKK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=237, Percent_Identity=30.8016877637131, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI155030236, Length=237, Percent_Identity=30.8016877637131, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=45.8536585365854, Blast_Score=177, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17506883, Length=229, Percent_Identity=30.5676855895196, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=229, Percent_Identity=30.5676855895196, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17137682, Length=238, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17738129, Length=266, Percent_Identity=27.4436090225564, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI22026807, Length=87, Percent_Identity=39.0804597701149, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26168; Mature: 26168

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPEYSRFYNILGYNFKDCTLLIRALTHRSKTKKNYERLEFLGDSVLSFVIAEVLYKQFT
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLAEGKLSQLRSKLVKGTTLAQLASSLKMDEYIILGASEQGGHKREKILEDVFEAVIGAI
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
YLDSDFATVKKVILKWYQPIISSINLDTIKVKDSKSKLQEILLQNALSLPEYSIETIDGK
HCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEECCCC
DHEQQFTVVAVSKDLNLRVKAQGTSRKKAEQKTAEKMIEMLSQQGLHEKK
CCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVPEYSRFYNILGYNFKDCTLLIRALTHRSKTKKNYERLEFLGDSVLSFVIAEVLYKQFT
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLAEGKLSQLRSKLVKGTTLAQLASSLKMDEYIILGASEQGGHKREKILEDVFEAVIGAI
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
YLDSDFATVKKVILKWYQPIISSINLDTIKVKDSKSKLQEILLQNALSLPEYSIETIDGK
HCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEECCCC
DHEQQFTVVAVSKDLNLRVKAQGTSRKKAEQKTAEKMIEMLSQQGLHEKK
CCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA