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The map label for this gene is lysP [H]

Identifier: 134301391

GI number: 134301391

Start: 285653

End: 287107

Strand: Direct

Name: lysP [H]

Synonym: FTW_0281

Alternate gene names: 134301391

Gene position: 285653-287107 (Clockwise)

Preceding gene: 134301390

Following gene: 134301392

Centisome position: 15.05

GC content: 35.33

Gene sequence:

>1455_bases
ATGTCGCAGAAACTTAAACGTGGCTTACATACTCGTCATATGTCAATGATAGCTCTAGGTGGCTGTATTGGTACTGGTTT
ATTTGTAGCACTTGGTGGAGCAATCGCTGATGCGGGTCCTGGAGGAACTGTCTTGGCGTATGTTATTATAGCTATAATGG
TTTATTTCTTGATGGCGAGTCTTGGCGAAATGGCTGCGCATAGCCCTGTTAGTGGCACATTTTGTGAATATGCTACGCGC
TATGTTGATCCAGCGTTAGGCTTTAGTACCGGTTGGAGTTATTGGTTTAATTGGGCTATTACAGTTGCTACAGAGGTTAT
TGCCGCAGCGTTAATTATGCAGTATTGGTTTCCAGGTAGTTCAATTCTGTTGTGGAGTGGATTTTTCTTTGTACTAGTTT
TTGCTTTGAATATCTTCTCAGTAAAAATATATGGTGAAGTTGAATATTGGTTATCTTTTATAAAAGTTTCTACAGTTATT
ATATTTATAATTGTTGGTTTCTTATCAATACTTGGTTTAGTAGGTAATCACCAAAGTGTTGGTTTTCAGAACTGGCATAT
CGGAGATGCTCCTTTTCATAATGGTTGGTGGGGCTTTATATCAGTATTCATGATTGCTGGATTTTCTTTCCAAGGTAGTG
AGCTTATAGGTGTAACAGCTGGAGAAGCGAAAGATCCAAATACATCTATACCAAAAGCAATCAAACAAACATTTTGGCGT
TTATTTATATTTTATATACTTGCTGTAGTGATTATTAGCTTCTTGATTCCATACAATAATCCATCTTTGATAAAAGCTGG
AGCAAGTAATGATGTTTCAGTTAGTCCATTTACAATAGTTTTTGAAAACGTTGGTTTGAATTCAGCGGCAACTATTATGA
ATGTAATTATATTAACTGCGATAATATCTGCATGTAATGCAAGTATGTATAGTGCGACAAGGGTACTATGGCATTTAGGT
AACATTAAGCAAGCCCCGCAGTTTTTTGCAACTACTAATTCAAAAGGTACGCCAATGATTGCTCTTTTGGTTACAGCAGT
TATAGGCTCGTCATTCTTCTTTGTATCTTTTGTTGGTAGTGGATATATATTTACATGGTTAGTCAACGTTTCAAGTTTAG
CGGGATTTATTGCATGGTTTACAATTGCACTTAGTCACTATCGTTTTAGAAGAGCATATATAAAGCAGGGTAAAAGCTTA
GAAGATTTACCATATGTAGCAAAGTTTTTCCCATGGGCGCCTATTATTGCTTTAACTATGGTAAGTATAGTAATCGTTGG
TCAAGGTGTTACAATGTTGACAATGGAGGGTAGAACTTGGTTTAGTGTAATAATAGAGTTTTTATCAACTTATATAGGTT
TCTTTGCATTTGTGATACTATATTTTGTATATAAGTTTATTAAAAAGACAAAATTGATAAGACTAGAAGATTGTGATCTT
ACTAGAGAATCTTAG

Upstream 100 bases:

>100_bases
TTTCTCAATTTCTCTAAATCTTATCTTAATCGTAAAGGGTTAAATCTATTAAACTCTTTAATTTTTTTAATTAATACCTT
TTTGGAGGGAAATAAAATAG

Downstream 100 bases:

>100_bases
TTGTAGTTATGGATACTTTTTTTATTCAAGGTCAAGCTGGTCGTATCGAGACAGCTTATGATAAAGTCAAAGGTGCCAAC
AAAGACATCGTTGCTGTAAT

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMASLGEMAAHSPVSGTFCEYATR
YVDPALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGSSILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVI
IFIIVGFLSILGLVGNHQSVGFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
LFIFYILAVVIISFLIPYNNPSLIKAGASNDVSVSPFTIVFENVGLNSAATIMNVIILTAIISACNASMYSATRVLWHLG
NIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGSGYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSL
EDLPYVAKFFPWAPIIALTMVSIVIVGQGVTMLTMEGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
TRES

Sequences:

>Translated_484_residues
MSQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMASLGEMAAHSPVSGTFCEYATR
YVDPALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGSSILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVI
IFIIVGFLSILGLVGNHQSVGFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
LFIFYILAVVIISFLIPYNNPSLIKAGASNDVSVSPFTIVFENVGLNSAATIMNVIILTAIISACNASMYSATRVLWHLG
NIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGSGYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSL
EDLPYVAKFFPWAPIIALTMVSIVIVGQGVTMLTMEGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
TRES
>Mature_483_residues
SQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMASLGEMAAHSPVSGTFCEYATRY
VDPALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGSSILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVII
FIIVGFLSILGLVGNHQSVGFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWRL
FIFYILAVVIISFLIPYNNPSLIKAGASNDVSVSPFTIVFENVGLNSAATIMNVIILTAIISACNASMYSATRVLWHLGN
IKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGSGYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSLE
DLPYVAKFFPWAPIIALTMVSIVIVGQGVTMLTMEGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDLT
RES

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI71999149, Length=340, Percent_Identity=26.1764705882353, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788480, Length=480, Percent_Identity=48.75, Blast_Score=483, Evalue=1e-138,
Organism=Escherichia coli, GI87081708, Length=429, Percent_Identity=37.995337995338, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994972, Length=428, Percent_Identity=37.1495327102804, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1786789, Length=432, Percent_Identity=34.9537037037037, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1786302, Length=395, Percent_Identity=34.6835443037975, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1786602, Length=391, Percent_Identity=35.8056265984655, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1790653, Length=444, Percent_Identity=32.6576576576577, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1789017, Length=426, Percent_Identity=30.5164319248826, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87081915, Length=418, Percent_Identity=32.5358851674641, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87081869, Length=408, Percent_Identity=22.5490196078431, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=493, Percent_Identity=36.9168356997972, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=493, Percent_Identity=35.2941176470588, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6324059, Length=491, Percent_Identity=35.8452138492872, Blast_Score=297, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6324990, Length=492, Percent_Identity=35.1626016260163, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6322892, Length=474, Percent_Identity=34.8101265822785, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=488, Percent_Identity=32.5819672131148, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=33.3333333333333, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6324553, Length=491, Percent_Identity=32.1792260692464, Blast_Score=264, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6322967, Length=432, Percent_Identity=32.8703703703704, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=476, Percent_Identity=30.672268907563, Blast_Score=249, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6324981, Length=473, Percent_Identity=33.4038054968288, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321053, Length=417, Percent_Identity=34.052757793765, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6319543, Length=468, Percent_Identity=30.982905982906, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319824, Length=489, Percent_Identity=30.6748466257669, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6319542, Length=491, Percent_Identity=30.3462321792261, Blast_Score=232, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6319608, Length=498, Percent_Identity=29.3172690763052, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320251, Length=488, Percent_Identity=29.3032786885246, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320364, Length=559, Percent_Identity=26.1180679785331, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53448; Mature: 53317

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGEMAAHSPVSGTFCEYATRYVDPALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGS
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVIIFIIVGFLSILGLVGNHQSV
HHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
LFIFYILAVVIISFLIPYNNPSLIKAGASNDVSVSPFTIVFENVGLNSAATIMNVIILTA
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
IISACNASMYSATRVLWHLGNIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGS
HHHHHCCHHHHHHHHHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHCC
GYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSLEDLPYVAKFFPWAPIIALTM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHH
VSIVIVGQGVTMLTMEGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
TRES
CCCC
>Mature Secondary Structure 
SQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGEMAAHSPVSGTFCEYATRYVDPALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGS
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVIIFIIVGFLSILGLVGNHQSV
HHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
LFIFYILAVVIISFLIPYNNPSLIKAGASNDVSVSPFTIVFENVGLNSAATIMNVIILTA
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
IISACNASMYSATRVLWHLGNIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGS
HHHHHCCHHHHHHHHHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHCC
GYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSLEDLPYVAKFFPWAPIIALTM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHH
VSIVIVGQGVTMLTMEGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
TRES
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]