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The map label for this gene is lpxK [H]

Identifier: 134301321

GI number: 134301321

Start: 201896

End: 202864

Strand: Direct

Name: lpxK [H]

Synonym: FTW_0195

Alternate gene names: 134301321

Gene position: 201896-202864 (Clockwise)

Preceding gene: 134301320

Following gene: 134301322

Centisome position: 10.63

GC content: 32.61

Gene sequence:

>969_bases
ATGCTAGATAAGATTTGGTACAGATCAAAACCAAACTTGCTTAGTCGGGTGCTACAACCAATATCTTTGGTTTTTATAGA
TATTGCAAATAAACGTAAAATAAAACAGCAACTCAAGCAATATAAATCAAAAATTCCTATAATAGTTGTTGGCAATATCT
CTGTTGGCGGTACTGGCAAAACTCCAGTTGTTAGAATGTTAGCTCAGCAATATTTAGCACAAGATAAAAAACCAGCTATA
ATTAGTCGTGGATATGGTGCAAAGGCTGATAATTATCCTTTTGAAGTAACAAGTGGTACTCTAGCAACTCAATGTGGCGA
TGAGCCTGCGATGTTATTTGATGCTTTGCAAGCACAGGTTCCTATTGTTATTGCTCCAGAGAGAGTTCAAGCTGTTAAAT
ACATTGAAAAGAATTTTCCTGATACAGATATAATTATGTCTGATGATGGCTTGCAACATTATAAATTAGCTAGAGATAAG
GAAATAGTGGTCGTAGATGCTATTAGAATGTTTGGCAACAAATTATGTTTGCCTGCTGGTCCATTGAGAGAACCGATTGA
GAGATTAAAAGAAGTAGATCAAATTATAGTTATAGGTAATTGCTCAGATAAAGATAAAGAGTTACTCAAAAACTATAAAA
ATGTGACTTATGCAAAAGTCGTAGCTACTGAATTTGTTAATATATTAACAGCTAAAAAAGTAGCTAAGACTGAATTTAAT
CATCAAAATGCAATAGCTATAGCCGGGATTGGCAATCCAACAAAATTTTTTAAGACTTTAGAAGAGAGTGCTATAAACAT
AACAGCTAAAAAAGTTTTTAAAGATCACCATAAGTTTACTCAGAGTGATTTTGAGGGTATAGATAGTGACATAACTGTAG
TGATGACATATAAAGATGCTATTAAATGCAAAAATTTTGCTAAAGCTAATTGGTGGTATCTGGATATAGCTTTAGATATC
AATGTTTAA

Upstream 100 bases:

>100_bases
TGGATGGTGGTAGGGTTGTTGAAAGTGGTAAGCATCAAGAATTGCTAGAGCAAGGTGGACTTTATACGAGGCTCTATCAA
TCAGGACTTCAATAGTACAT

Downstream 100 bases:

>100_bases
AAATCTCATAAAACAACAATGTTACAACAAATGAATTTGCTATACTAAAGTATATATATTACTATTAAAATGATAAAAAA
ATTGCAATAAAATCTATGAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MLDKIWYRSKPNLLSRVLQPISLVFIDIANKRKIKQQLKQYKSKIPIIVVGNISVGGTGKTPVVRMLAQQYLAQDKKPAI
ISRGYGAKADNYPFEVTSGTLATQCGDEPAMLFDALQAQVPIVIAPERVQAVKYIEKNFPDTDIIMSDDGLQHYKLARDK
EIVVVDAIRMFGNKLCLPAGPLREPIERLKEVDQIIVIGNCSDKDKELLKNYKNVTYAKVVATEFVNILTAKKVAKTEFN
HQNAIAIAGIGNPTKFFKTLEESAINITAKKVFKDHHKFTQSDFEGIDSDITVVMTYKDAIKCKNFAKANWWYLDIALDI
NV

Sequences:

>Translated_322_residues
MLDKIWYRSKPNLLSRVLQPISLVFIDIANKRKIKQQLKQYKSKIPIIVVGNISVGGTGKTPVVRMLAQQYLAQDKKPAI
ISRGYGAKADNYPFEVTSGTLATQCGDEPAMLFDALQAQVPIVIAPERVQAVKYIEKNFPDTDIIMSDDGLQHYKLARDK
EIVVVDAIRMFGNKLCLPAGPLREPIERLKEVDQIIVIGNCSDKDKELLKNYKNVTYAKVVATEFVNILTAKKVAKTEFN
HQNAIAIAGIGNPTKFFKTLEESAINITAKKVFKDHHKFTQSDFEGIDSDITVVMTYKDAIKCKNFAKANWWYLDIALDI
NV
>Mature_322_residues
MLDKIWYRSKPNLLSRVLQPISLVFIDIANKRKIKQQLKQYKSKIPIIVVGNISVGGTGKTPVVRMLAQQYLAQDKKPAI
ISRGYGAKADNYPFEVTSGTLATQCGDEPAMLFDALQAQVPIVIAPERVQAVKYIEKNFPDTDIIMSDDGLQHYKLARDK
EIVVVDAIRMFGNKLCLPAGPLREPIERLKEVDQIIVIGNCSDKDKELLKNYKNVTYAKVVATEFVNILTAKKVAKTEFN
HQNAIAIAGIGNPTKFFKTLEESAINITAKKVFKDHHKFTQSDFEGIDSDITVVMTYKDAIKCKNFAKANWWYLDIALDI
NV

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=320, Percent_Identity=38.4375, Blast_Score=241, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 36194; Mature: 36194

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKIWYRSKPNLLSRVLQPISLVFIDIANKRKIKQQLKQYKSKIPIIVVGNISVGGTGK
CCCCCCCCCCHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCEEEEECEEECCCCC
TPVVRMLAQQYLAQDKKPAIISRGYGAKADNYPFEVTSGTLATQCGDEPAMLFDALQAQV
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEECCCEECCCCCCHHHHHHHHHHCC
PIVIAPERVQAVKYIEKNFPDTDIIMSDDGLQHYKLARDKEIVVVDAIRMFGNKLCLPAG
CEEECCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCCCEEEEEEHHHHCCEECCCCC
PLREPIERLKEVDQIIVIGNCSDKDKELLKNYKNVTYAKVVATEFVNILTAKKVAKTEFN
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
HQNAIAIAGIGNPTKFFKTLEESAINITAKKVFKDHHKFTQSDFEGIDSDITVVMTYKDA
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHH
IKCKNFAKANWWYLDIALDINV
HHHCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MLDKIWYRSKPNLLSRVLQPISLVFIDIANKRKIKQQLKQYKSKIPIIVVGNISVGGTGK
CCCCCCCCCCHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCEEEEECEEECCCCC
TPVVRMLAQQYLAQDKKPAIISRGYGAKADNYPFEVTSGTLATQCGDEPAMLFDALQAQV
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEECCCEECCCCCCHHHHHHHHHHCC
PIVIAPERVQAVKYIEKNFPDTDIIMSDDGLQHYKLARDKEIVVVDAIRMFGNKLCLPAG
CEEECCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCCCEEEEEEHHHHCCEECCCCC
PLREPIERLKEVDQIIVIGNCSDKDKELLKNYKNVTYAKVVATEFVNILTAKKVAKTEFN
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
HQNAIAIAGIGNPTKFFKTLEESAINITAKKVFKDHHKFTQSDFEGIDSDITVVMTYKDA
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHH
IKCKNFAKANWWYLDIALDINV
HHHCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7881549 [H]