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The map label for this gene is hisS

Identifier: 134301266

GI number: 134301266

Start: 138583

End: 139848

Strand: Direct

Name: hisS

Synonym: FTW_0128

Alternate gene names: 134301266

Gene position: 138583-139848 (Clockwise)

Preceding gene: 134301265

Following gene: 134301267

Centisome position: 7.3

GC content: 34.68

Gene sequence:

>1266_bases
ATGAGTAAGCTTACTATTGTTCGTGGATTTAATGATGTATTGCCACTAGACAGTTATAAATGGCAACTCTTGGAATCAAA
AGTAAAACTCATACTTGATAGATATAACTACAGTGAAACAAGATTGCCTATTGTTGAGAGGAGCGAATTGTTTCATAGAA
GTGTAGGTGAAAGTTCTGATATAGTTTCAAAAGAGACTTATGACTTTCAAGATCGTAATGGTGATAGCCTGACATTGCGT
CCAGAAGGAACAGCTGGCTGTGTTAGGATGGTTATTGAAAATAATTTGGCTACTCGAGGCCAAACACAGAAACTATGGTA
TTGTGGACCTATGTTTCGCTATGAGCGCCCACAAAAAGGCCGCTATAGACAATTTTATCAGCTTGGGGTTGAGGCTTATG
GCTTTGATGGTATAGCTATTGATTTAGAGGTTATTGCTATAGCTTGGAGTCTTTTCAAAGAGCTTGGGATTTATGAGTAT
GTAACTTTAGAACTAAATAGCCTTGGTTCTAGTCTTAACAGACAAGAGTATACTCAAGCGCTATTACAATACCTAAAACC
ATATCATGCTGAGCTTGATGAAGATTCTATCAAGAGGTTGGATAAAAATCCTCTAAGAATATTAGATTCTAAGATAGAAA
AAACACAAAAAATCTTAGCAAACGCACCTAAACTTATTGATTTTATAGATCATGATTTGCGTTTGAGATTTAAACAAACT
TGTCAATATTTAGATGCCTTGGGTGTCAGATATAAATTAAATGAAAATCTTGTTAGAGGTTTGGATTATTATACTGGTTT
AGTTTTTGAATGGACTACTGATAAACTTGGTTCACAGAGTGCAATCTGTGCAGGTGGTCGTTATGATGGTCTTGTAGAGA
ATCTTGGTGGTCAGAAAACTGCTGCGATAGGATTTGCTATAGGTATGGAGCGTTTGTTACTCTTATTAGAAGATTTAGGT
AAATTACCTAATCAAGATAATGCTTGTGATGTGTTTTTCATATTAGATAGTGCCCAGCTGCATCAATCTCTTGCTATAGT
AGAGAATATTCGCCAAGAGCTTCCCCAACTTAAAATAGATATGGATCTAAAGTTTGGTAGTTTTAAATCACAATTTAAGA
AAGCGGATAAATCTGGAGCTAAAGTTGCTATAATAATCGGCCAAGATGAGTTAGATAATGGCTTTGCTGGTATAAAATTT
CTTCAACAAAATGAAGAACAACAACAAGTTGCTTTTAATGAGTTAATAAATTTTTTAGAAAGATAG

Upstream 100 bases:

>100_bases
GCTGACTCAAAAATTATCAAGCAAGATGATAAATCTTTACAAGAAAATTATAAGCAAAACGATAAAGAAACTAAAGCTGA
GAAGTTAAGGTAGGTAGCTT

Downstream 100 bases:

>100_bases
AGGTTTATGAAATTACATAATATAAAGGGCTATGCTTGGATTGTAGTTGGGTTAAGCTCATTTCTACTAATCGATAAATA
TATAATGAATGTTTCTCCTA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLR
PEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGIYEY
VTLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKTAAIGFAIGMERLLLLLEDLG
KLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKF
LQQNEEQQQVAFNELINFLER

Sequences:

>Translated_421_residues
MSKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLR
PEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGIYEY
VTLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKTAAIGFAIGMERLLLLLEDLG
KLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKF
LQQNEEQQQVAFNELINFLER
>Mature_420_residues
SKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLRP
EGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGIYEYV
TLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQTC
QYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKTAAIGFAIGMERLLLLLEDLGK
LPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFL
QQNEEQQQVAFNELINFLER

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=425, Percent_Identity=24.9411764705882, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI15029520, Length=426, Percent_Identity=24.1784037558685, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788861, Length=408, Percent_Identity=50, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71993693, Length=474, Percent_Identity=24.6835443037975, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71993686, Length=474, Percent_Identity=24.6835443037975, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_FRAT1 (Q14K18)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666258.1
- ProteinModelPortal:   Q14K18
- SMR:   Q14K18
- STRING:   Q14K18
- GeneID:   4200195
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0052
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- PhylomeDB:   Q14K18
- ProtClustDB:   PRK00037
- BioCyc:   FTUL393115:FTF0052-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48227; Mature: 48096

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSD
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
IVSKETYDFQDRNGDSLTLRPEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKG
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCHHHCCCCCCC
RYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGIYEYVTLELNSLGSSLNRQEYTQA
HHHHHHHHCCHHCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCHHHHHHH
LLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
HHHHHCHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHH
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKT
HHHHHHCCCEEEECHHHHHHHHHHHCEEEEECCCCCCCCCCEECCCCCHHHHHHCCCCHH
AAIGFAIGMERLLLLLEDLGKLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEE
MDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFLQQNEEQQQVAFNELINFLE
EEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
R
C
>Mature Secondary Structure 
SKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSD
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
IVSKETYDFQDRNGDSLTLRPEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKG
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCHHHCCCCCCC
RYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGIYEYVTLELNSLGSSLNRQEYTQA
HHHHHHHHCCHHCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCHHHHHHH
LLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
HHHHHCHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHH
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKT
HHHHHHCCCEEEECHHHHHHHHHHHCEEEEECCCCCCCCCCEECCCCCHHHHHHCCCCHH
AAIGFAIGMERLLLLLEDLGKLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEE
MDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFLQQNEEQQQVAFNELINFLE
EEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA