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The map label for this gene is nhaA [H]

Identifier: 134301189

GI number: 134301189

Start: 23083

End: 24234

Strand: Reverse

Name: nhaA [H]

Synonym: FTW_0027

Alternate gene names: 134301189

Gene position: 24234-23083 (Counterclockwise)

Preceding gene: 134301198

Following gene: 134301188

Centisome position: 1.28

GC content: 32.9

Gene sequence:

>1152_bases
ATGGGTGCAAGCCAAAAAAATCAAGAGCTCATTGGTGGTTTAATACTTTTCTCAGCAGCTTTGTTAGCTATTGTTGTTAA
TAATTCGCCATTAGCAAGCTACTATGCAATGCTTGAAACTATCAATGTAAAACTTGGGATAGAAAACTTGGTAATTGATA
AGAATCTAATGCATTGGATAAATGATGGTTTAATGGCGATATATTTTTTGTATATTGGTTTAGAAATAAAAAGAGAAATC
ATCGTTGGCACCCTTTCAAAGCCATCAAATATAATAACACCAGCTATAGCGGCATTTGCAGGTTTGGCGATGCCAAGCTT
GATATATCTATCAATAAACCATGATATTAAGGTTATCAATGGTTGGGCAATACCATCAGCTACAGATATAGCATTTACAT
TGGCTATATTAGCACTACTAGGAACAAGAGTTCCAGCTAAATTAAAGTTACTGGTTATTACTATAGCTATTTTTGATGAT
ATAGCTGCGATAGCTATTATAGCGATATTTTATACCAAATCTTTATCTTTACTTTCGTTATCTCTAGGAACGCTTTTTAT
TCTTGCGATGATTATTTGCAATCGTATATTTAAGATAAATAGAAGTTCGGTGTATGTAGTGCTTGGCTTTTTTGCATGGT
TTTGTACGATCAAATCTGGGGTGCATGCGACTTTAGCAGGTTTTACTACGGCTCTATGTATACCTTTTAGAGAGAATGAT
AAAGATTCTCCAGCTAATTTTATGGAAGATTCTCTTCACCCTTGGATTATCTATTTTATATTACCAGTTTTTGCCTTTGC
TAATGCTGGAATAAGCTTCTCTGGGATAAGCTTTTCGATATTGTTTGAGCCTATTACATTAGGTATTATTTGGGGCTTAT
TTGTTGGCAAACAGCTTGGAATTTTTTCAATATTAGCAGTTTTCAAAAAGTTAAAATGGTTTAAACTCGGCGAGTCTTTT
TCAAACTTACAGTTATATGGTATAAGTTTGTTGTGTGGTATTGGCTTTACTATGAGTTTATTTATAGGAGTACTTGCTTT
TAATGATACTCACTTACTTAATGCTATAAAAATAGGTGTGGTTGTTGGTTCAGTTCTTTCAGGATTTTTTGGTTATATTG
TTTTGAGATTTATTGTTACAAATCCTAGCTAA

Upstream 100 bases:

>100_bases
TTTTCATTCTCTATGGCAAAAATAATTTTTGTATAGGTGGAATTATACCTTAAGCTATTAGATAATTAATAATAATCAAA
TCTCTAAATAACCAATAAAT

Downstream 100 bases:

>100_bases
AATGATTTTATCTAATAATTTTAATATATAATAAAGCTATACTATGCCAGCCTTAAGTGGTTAGATGTTTGAATTAAACT
CAAAAGATAATGACTCTAAA

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MGASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREI
IVGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVINGWAIPSATDIAFTLAILALLGTRVPAKLKLLVITIAIFDD
IAAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFREND
KDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLGIFSILAVFKKLKWFKLGESF
SNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGVVVGSVLSGFFGYIVLRFIVTNPS

Sequences:

>Translated_383_residues
MGASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREI
IVGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVINGWAIPSATDIAFTLAILALLGTRVPAKLKLLVITIAIFDD
IAAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFREND
KDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLGIFSILAVFKKLKWFKLGESF
SNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGVVVGSVLSGFFGYIVLRFIVTNPS
>Mature_382_residues
GASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREII
VGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVINGWAIPSATDIAFTLAILALLGTRVPAKLKLLVITIAIFDDI
AAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFRENDK
DSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLGIFSILAVFKKLKWFKLGESFS
NLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGVVVGSVLSGFFGYIVLRFIVTNPS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=355, Percent_Identity=46.7605633802817, Blast_Score=290, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 41756; Mature: 41625

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWI
CCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHEEECHHHHEECHHHHHHH
NDGLMAIYFLYIGLEIKREIIVGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVIN
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCEEEEE
GWAIPSATDIAFTLAILALLGTRVPAKLKLLVITIAIFDDIAAIAIIAIFYTKSLSLLSL
EECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
SLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFREND
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCC
KDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLG
CCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHHHHHHHHHHH
IFSILAVFKKLKWFKLGESFSNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGV
HHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGSVLSGFFGYIVLRFIVTNPS
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWI
CCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHEEECHHHHEECHHHHHHH
NDGLMAIYFLYIGLEIKREIIVGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVIN
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCEEEEE
GWAIPSATDIAFTLAILALLGTRVPAKLKLLVITIAIFDDIAAIAIIAIFYTKSLSLLSL
EECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
SLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFREND
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCC
KDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLG
CCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHHHHHHHHHHH
IFSILAVFKKLKWFKLGESFSNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGV
HHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGSVLSGFFGYIVLRFIVTNPS
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA