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The map label for this gene is mre11 [H]

Identifier: 134300410

GI number: 134300410

Start: 2801151

End: 2802512

Strand: Reverse

Name: mre11 [H]

Synonym: Dred_2571

Alternate gene names: 134300410

Gene position: 2802512-2801151 (Counterclockwise)

Preceding gene: 134300412

Following gene: 134300409

Centisome position: 77.67

GC content: 49.34

Gene sequence:

>1362_bases
ATGCCGGCACTAAAATTTATACATTGTTCGGATATACACCTGGGACGTCAGCGACTGGGTGGAAAACTACCCGATGAAGA
TTTCGCCAGGGCCCTGGGCTATATTGTACAGGTGGCCCTAGAGCAAAGGGTAGATGGCCTATTAGTGGCGGGGGATTTAT
ATGATTCCCCTAGTATACAGCCACCCATACTGCAACAGGCCATCAATTGTTTAATGCCATTGCAAGAAGCCAATATTCCC
ATTTTTATTATTGAAGGCAATCATGACCGGGCCACGGTGACAGGAGAAACCCATACATGGGTACGCTATTTAAATGATAT
TGGACTTGTTCATCTTCTATCCATTCCCTTTAATGCAGAGGGACCTGTGTTAACACCCTGGGATGATACCGCAAAGCGGG
GTTCTTACATTGATTACAAAGGTGTTCGCATCATTGGAGCCGGTTATCTGGGAGCAGGTACCATTAAAAGGGCACGGTTA
ATCTCCGAGGCAATGGATCAGTGGCAGGAGCCTGTTCCCACCGCTAAAATTATGCTGCTCCATGCCGGGCCCGATTATAT
GGTGCAGGAAGGTGGTGGCTTTTCCAAGGAGACACTGGAATTCTTGCATGAGAGGGTGGATTACCTAGCCCTGGGACACA
TTCACAAGCCGCTTAACCATGATGGCTGGGCTGTAAATCCCGGTTCTCCGGAACATGTTCGTCTGGAAGAATGCCGCTAT
GATGGGCAACCACGGGGTATGGCCGTGATGGAAATAGATCCCTTTGCGCCACACCCCTTACAAAGGGCGGAAATTTTAAG
TGTCCCAAAAAGAAGGGTAATTAACCTCCGCTATGATTGCTCGCCCCACGGTAACAAAACAAAGCGGGCAATGGATGGTA
TTCAGCAGGAGGTTGCTACTTTGCTAAAGGAAGCAGGGGCTGGATCGGAAGATGCAGTGCGCCTAGAATTAACCGGTGCA
GTGAACCTAGGACGTATTCGATTGGACACCGATGCACTGGCCACCTTTTTGGAAGAAAAGCTGCCGGTGAAAGCCGTTGA
AATTAATTCCGGGGGATTACAGCTAGCAACCGGAGACATTGTAGGGGCAGAAACGGCAGATACCAGCCCCTCTCGGGAGT
CTATCGAACTTAGGGCCATTAGCGATCTGGTGTGGGAGCATCCCTTGGCGGGGCTGGAAGAACATACGGACTTGGTGGCA
GACTTATTTTACCAGCTTAAAGAAGATGTACGAAACAAGCTTGGTTCTGAGGAAATTCGTGAACGTCTTAACACCAATAG
TCTGGTGGATCGTCTGGTAGCAGAAATGTTGGCGGAAATGCCAGAACGTTCGGTGGCATCGGCAAAGGACGGTGATAACT
AA

Upstream 100 bases:

>100_bases
CTATAGGTGGTGGTATCCCGTCGGAGGCTTCGGTATAATTGATTAAGAAAGGACAAACCCGAATACTCACACGTGGATTT
GAAAAAAGGAGTGCAAAGAA

Downstream 100 bases:

>100_bases
TGTGGGTGCAAAGGGTAAGATTGAAGAATATAAAAAGCTACGGTGAGGGGGAAAAGGGTCAGGGTGTTACCATCCACTTG
GAACCCGGTATCAACCAGAT

Product: metallophosphoesterase

Products: NA

Alternate protein names: pfMre11 [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MPALKFIHCSDIHLGRQRLGGKLPDEDFARALGYIVQVALEQRVDGLLVAGDLYDSPSIQPPILQQAINCLMPLQEANIP
IFIIEGNHDRATVTGETHTWVRYLNDIGLVHLLSIPFNAEGPVLTPWDDTAKRGSYIDYKGVRIIGAGYLGAGTIKRARL
ISEAMDQWQEPVPTAKIMLLHAGPDYMVQEGGGFSKETLEFLHERVDYLALGHIHKPLNHDGWAVNPGSPEHVRLEECRY
DGQPRGMAVMEIDPFAPHPLQRAEILSVPKRRVINLRYDCSPHGNKTKRAMDGIQQEVATLLKEAGAGSEDAVRLELTGA
VNLGRIRLDTDALATFLEEKLPVKAVEINSGGLQLATGDIVGAETADTSPSRESIELRAISDLVWEHPLAGLEEHTDLVA
DLFYQLKEDVRNKLGSEEIRERLNTNSLVDRLVAEMLAEMPERSVASAKDGDN

Sequences:

>Translated_453_residues
MPALKFIHCSDIHLGRQRLGGKLPDEDFARALGYIVQVALEQRVDGLLVAGDLYDSPSIQPPILQQAINCLMPLQEANIP
IFIIEGNHDRATVTGETHTWVRYLNDIGLVHLLSIPFNAEGPVLTPWDDTAKRGSYIDYKGVRIIGAGYLGAGTIKRARL
ISEAMDQWQEPVPTAKIMLLHAGPDYMVQEGGGFSKETLEFLHERVDYLALGHIHKPLNHDGWAVNPGSPEHVRLEECRY
DGQPRGMAVMEIDPFAPHPLQRAEILSVPKRRVINLRYDCSPHGNKTKRAMDGIQQEVATLLKEAGAGSEDAVRLELTGA
VNLGRIRLDTDALATFLEEKLPVKAVEINSGGLQLATGDIVGAETADTSPSRESIELRAISDLVWEHPLAGLEEHTDLVA
DLFYQLKEDVRNKLGSEEIRERLNTNSLVDRLVAEMLAEMPERSVASAKDGDN
>Mature_452_residues
PALKFIHCSDIHLGRQRLGGKLPDEDFARALGYIVQVALEQRVDGLLVAGDLYDSPSIQPPILQQAINCLMPLQEANIPI
FIIEGNHDRATVTGETHTWVRYLNDIGLVHLLSIPFNAEGPVLTPWDDTAKRGSYIDYKGVRIIGAGYLGAGTIKRARLI
SEAMDQWQEPVPTAKIMLLHAGPDYMVQEGGGFSKETLEFLHERVDYLALGHIHKPLNHDGWAVNPGSPEHVRLEECRYD
GQPRGMAVMEIDPFAPHPLQRAEILSVPKRRVINLRYDCSPHGNKTKRAMDGIQQEVATLLKEAGAGSEDAVRLELTGAV
NLGRIRLDTDALATFLEEKLPVKAVEINSGGLQLATGDIVGAETADTSPSRESIELRAISDLVWEHPLAGLEEHTDLVAD
LFYQLKEDVRNKLGSEEIRERLNTNSLVDRLVAEMLAEMPERSVASAKDGDN

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 50019; Mature: 49887

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALKFIHCSDIHLGRQRLGGKLPDEDFARALGYIVQVALEQRVDGLLVAGDLYDSPSIQ
CCCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
PPILQQAINCLMPLQEANIPIFIIEGNHDRATVTGETHTWVRYLNDIGLVHLLSIPFNAE
CHHHHHHHHHHCCHHHCCCCEEEEECCCCCEEEECCHHHHHHHHHHCCEEEEEECCCCCC
GPVLTPWDDTAKRGSYIDYKGVRIIGAGYLGAGTIKRARLISEAMDQWQEPVPTAKIMLL
CCEECCCCCHHCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
HAGPDYMVQEGGGFSKETLEFLHERVDYLALGHIHKPLNHDGWAVNPGSPEHVRLEECRY
ECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEHHHHCC
DGQPRGMAVMEIDPFAPHPLQRAEILSVPKRRVINLRYDCSPHGNKTKRAMDGIQQEVAT
CCCCCCEEEEEECCCCCCCCCHHHHHHCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHH
LLKEAGAGSEDAVRLELTGAVNLGRIRLDTDALATFLEEKLPVKAVEINSGGLQLATGDI
HHHHCCCCCCCEEEEEEECCEEECEEEECHHHHHHHHHHCCCEEEEEECCCCEEEEECCE
VGAETADTSPSRESIELRAISDLVWEHPLAGLEEHTDLVADLFYQLKEDVRNKLGSEEIR
ECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ERLNTNSLVDRLVAEMLAEMPERSVASAKDGDN
HHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
>Mature Secondary Structure 
PALKFIHCSDIHLGRQRLGGKLPDEDFARALGYIVQVALEQRVDGLLVAGDLYDSPSIQ
CCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
PPILQQAINCLMPLQEANIPIFIIEGNHDRATVTGETHTWVRYLNDIGLVHLLSIPFNAE
CHHHHHHHHHHCCHHHCCCCEEEEECCCCCEEEECCHHHHHHHHHHCCEEEEEECCCCCC
GPVLTPWDDTAKRGSYIDYKGVRIIGAGYLGAGTIKRARLISEAMDQWQEPVPTAKIMLL
CCEECCCCCHHCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
HAGPDYMVQEGGGFSKETLEFLHERVDYLALGHIHKPLNHDGWAVNPGSPEHVRLEECRY
ECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEHHHHCC
DGQPRGMAVMEIDPFAPHPLQRAEILSVPKRRVINLRYDCSPHGNKTKRAMDGIQQEVAT
CCCCCCEEEEEECCCCCCCCCHHHHHHCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHH
LLKEAGAGSEDAVRLELTGAVNLGRIRLDTDALATFLEEKLPVKAVEINSGGLQLATGDI
HHHHCCCCCCCEEEEEEECCEEECEEEECHHHHHHHHHHCCCEEEEEECCCCEEEEECCE
VGAETADTSPSRESIELRAISDLVWEHPLAGLEEHTDLVADLFYQLKEDVRNKLGSEEIR
ECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ERLNTNSLVDRLVAEMLAEMPERSVASAKDGDN
HHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11029422 [H]